Conagen develops high-purity non-GMO sulforaphane by bioconversion

Bedford, Mass., Nov. 29, 2022 (GLOBE NEWSWIRE) — Expanding on its portfolio of innovative nutritional products through biotechnology, Conagen, announced the development of its 99% high–purity sulforaphane. Made by a proprietary bioconversion technology, the company plans to begin the commercialization path in 2023. Conagen's bioconversion methods enable the production of sustainable products from many naturally occurring compounds regardless of rarity or small quantities occurring in nature.

"As a supplement product, Conagen's high–purity sulforaphane is appealing to consumers as the levels found in raw vegetables are too low to realize many of its promising health benefits," said Casey Lippmeier, Ph.D., senior vice president of innovation. "We're looking forward to expanding the nutritional market by commercializing sulforaphane in 2023."

Sulforaphane has been associated with supporting health benefits against cancer, diabetes, digestion, and heart disease and promoting cognition. With biotechnology and biomanufacturing advancements, much like Conagen's bioconversion technology, more nutritional offerings are produced at a high–quality and global scale.

Sulforaphane is found in cruciferous vegetables such as arugula, bok choy, broccoli, Brussels sprouts, cabbage, kale, radish, and more. In these vegetables, the inactive form of glucoraphanin belongs to the glucosinolate family of plant compounds. The sulfur–rich sulforaphane is activated only when vegetables are chewed or chopped to release myrosinase, a class of enzymes that play a role in the defense response of plants.

"Through Conagen's bioconversion technology, we're uncovering the great potential in sulforaphane as a powerful active health ingredient for consumers who are personalizing nutrition to support health functions," said Lippmeier. "We can make safe and high–quality nutritional ingredients from natural sources and offer it at a global–scale cost–competitively so that brands may pass on the good health and savings to their consumers."

Conagen's sulforaphane is ideal for non–GMO supplement solutions to formulate products with a sustainable and natural consumer appeal. More research is emerging for understanding the optimistic effects on multiple health functions. As one example of many, biotechnology and biomanufacturing will continue to harness the power of biology and nature to develop and deliver solutions for better nutrition, health, and wellness. Conagen is expanding its sustainable, nutritional products portfolio to better humankind and the planet.

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About Conagen
Conagen is making the impossible possible. Our scientists and engineers use modern synthetic biology tools to program micro–organisms and enzymes on a molecular level to produce high–quality, sustainable, natural products manufactured worldwide via precision fermentation and bioconversion. We focus on the bioproduction of high–value ingredients for food, nutrition, flavors and fragrances, pharmaceuticals, and renewable materials.

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Vaccine Refusal, Floods Impact Polio Drive in Pakistan

A young child receives vaccine drops in Pakistan, but the region has experienced an upsurgence of cases because of vaccine refusal. Credit: Ashfaq Yusufzai/IPS

A young child receives vaccine drops in Pakistan, but the region has experienced an upsurgence of cases because of vaccine refusal. Credit: Ashfaq Yusufzai/IPS

By Ashfaq Yusufzai
PESHAWAR, Nov 29 2022 – Vaccine refusal is impacting the eradication of polio in Pakistan.

Pakistan has vaccinated about 35 million children during its door-to-door campaign, but about 500,000 remained unvaccinated due to refusal by their parents, Jawad Khan Polio officer in Khyber Pakhtunkhwa, recorded in 2022 so far.

Khyber Pakhtunkhwa, one of Pakistan’s four provinces, has reported all 20 polio cases. North Waziristan has detected 17 infections, Lakki Marwat 2 and South Waziristan 1.

Khan says that hesitancy against vaccination is not a new trend, as Pakistan has been facing this problem since the start of the polio-eradication campaign in the 90s.

Of the 17 cases reported in militancy-riddled North Waziristan, 12 were not vaccinated, while five were partially immunized.

Muhammad Shah, whose son was diagnosed with the polio virus in August, told IPS that he had been opposing vaccination because this wasn’t allowed in Islam.

“Our religion Islam says that no medication is permissible before the occurrence of any ailment; therefore, our people defy vaccination to fulfill their religious obligations,” he said. Shah, a religious preacher, says his son will soon recover from the paralysis.

He says he was unrepentant in refusing vaccination of his child and would continue to thwart efforts by vaccinators to inoculate the toddler.

North Waziristan district, located near Afghanistan’s border, has many militants who staunchly oppose vaccination.

“It was the hub of the polio virus till 2014 when militants ruled the area illegitimately as there was a complete ban on all sorts of immunization. The Taliban militants were evicted through a military operation in 2014, and parents started vaccinating their kids,” Sajjad Ahmed, a senior health worker, said.

According to him, polio vaccinations have decreased with the emergence of militancy in the area.

“In the last three months, three persons, including two policemen and one health worker, have been killed by unknown assailants during a polio drive in North Waziristan,” he said.

People are afraid to take part in the campaign due to fear of reprisals by Taliban militants, he said.

Dr Rafiq Khan, associated with polio immunization in the region, told IPS that parents refuse vaccination, arguing that it was a US and Western plot to render recipients impotent and cut the population of Muslims – a baseless argument.

“Alleged Taliban have killed about 70 vaccinators and policemen since 2012. Government deploys 25,000 policemen in each three-day campaign to ensure the safety of workers,” he said.

Khan said that militants are pressuring the people against vaccination, due to which parents weren’t willing to administer jabs to their kids below five years.

“We are also facing fake finger marking of kids. As a standard procedure, our vaccinators mark the thumb of the vaccine recipients with indelible ink so that we know how many children have been immunized,” he said.

However, the parents ask the vaccinators to mark their kids’ fingers without vaccination, he said. In this way, parents deceive the government.

“Now, we have started convincing the parents through community elders and religious scholars to create demand for vaccination,” he said.

The government has enlisted the services of religious scholars to do away with refusals against poliomyelitis.

Maulana Amir Haq, a pro-vaccination cleric, told IPS that they had been holding awareness sessions with people telling them vaccination is allowed in Islam.

“It is the responsibility of the parents to safeguard their kids against diseases and vaccination aimed to prevent the crippling ailments. There, parents should fulfill their religious duty and inoculate their sons and daughters,” he said.

He said that laboratory reports confirm vaccines given to Pakistan’s children are safe and don’t contain any ingredient to sterilise the recipients. The situation is changing because we now reach hardcore refusal cases and vaccinate them.

Federal Health Minister Abdul Qadir Patel said that it is crucial to understand that the only protection from polio is vaccination, and parents should protect their children against disability through free immunization.

“We want to wipe out the virus and safeguard not only our own kids but all around the world,” he told IPS.

Polio will keep haunting us until we interrupt transmission, Federal Health Secretary Dr. Muhammad Fakhre Alam said.

On August 31, a 16-year-old boy was diagnosed positive for polio in Waziristan, which shows how robust Pakistan’s virus detection network is because it highlights that we can identify polio cases in children outside the usually expected age, he said.

National Emergency Operations Centre Coordinator for polio, Dr Shahzad Baig, expressed concerns about the spread of wild poliovirus as millions of people in the country are displaced by recent floods.

“The scale of the current calamity is absolutely devastating. As part of the polio programme, our network of health workers is here to support in every way we can, but I am deeply concerned about the virus gaining a foothold as millions of people leave their homes and look for refuge elsewhere,” he said.

The province of Balochistan and parts of southern Punjab, and 23 districts of Sindh were unable to hold a vaccination drive as floods swept away homes and villages around the country. Despite the extreme climatic conditions, polio teams reached children in all accessible areas, he said.

Neighbouring Afghanistan is facing the same problems; however, it has detected only two cases this year.

IPS UN Bureau Report

 


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Can Asia and the Pacific Get on Track to Net Zero?

By Armida Salsiah Alisjahbana
BANGKOK, Thailand, Nov 29 2022 – The recent climate talks in Egypt have left us with a sobering reality: The window for maintaining global warming to 1.5 degrees is closing fast and what is on the table currently is insufficient to avert some of the worst potential effects of climate change. The Nationally Determined Contribution targets of Asian and Pacific countries will result in a 16 per cent increase in greenhouse gas emissions by 2030 from the 2010 levels.

Armida Salsiah Alisjahbana

The Sharm-el Sheikh Implementation Plan and the package of decisions taken at COP27 are a reaffirmation of actions that could deliver the net-zero resilient world our countries aspire to. The historic decision to establish a Loss and Damage Fund is an important step towards climate justice and building trust among countries.

But they are not enough to help us arrive at a better future without, what the UN Secretary General calls, a “giant leap on climate ambition”. Carbon neutrality needs to at the heart of national development strategies and reflected in public and private investment decisions. And it needs to cascade down to the sustainable pathways in each sector of the economy.

Accelerate energy transition

At the Economic and Social Commission for Asia and the Pacific (ESCAP), we are working with regional and national stakeholders on these transformational pathways. Moving away from the brown economy is imperative, not only because emissions are rising but also because dependence on fossil fuels has left economies struggling with price volatility and energy insecurity.

A clear road map is the needed springboard for an inclusive and just energy transition. We have been working with countries to develop scenarios for such a shift through National Roadmaps, demonstrating that a different energy future is possible and viable with the political will and sincere commitment to action of the public and private sectors.

The changeover to renewables also requires concurrent improvements in grid infrastructure, especially cross-border grids. The Regional Road Map on Power System Connectivity provides us the platform to work with member States toward an interconnected grid, including through the development of the necessary regulatory frameworks for to integrate power systems and mobilize investments in grid infrastructure. The future of energy security will be determined by the ability to develop green grids and trade renewable-generated electricity across our borders.

Green the rides

The move to net-zero carbon will not be complete without greening the transport sector. In Asia and the Pacific transport is primarily powered by fossil fuels and as a result accounted for 24 per cent of total carbon emissions by 2018.

Energy efficiency improvements and using more electric vehicles are the most effective measures to reduce carbon emissions by as much as 60 per cent in 2050 compared to 2005 levels. The Regional Action Programme for Sustainable Transport Development allows us to work with countries to implement and cooperate on priorities for low-carbon transport, including electric mobility. Our work with the Framework Agreement on Facilitation of Cross-border Paperless Trade also is helping to make commerce more efficient and climate-smart, a critical element for the transition in the energy and transport sectors.

Adapting to a riskier future

Even with mitigation measures in place, our economy and people will not be safe without a holistic risk management system. And it needs to be one that prevents communities from being blindsided by cascading climate disasters.

We are working with partners to deepen the understanding of such cascading risks and to help develop preparedness strategies for this new reality, such as the implementation of the ASEAN Regional Plan of Action for Adaptation to Drought.

Make finance available where it matters the most

Finance and investment are uniquely placed to propel the transitions needed. The past five years have seen thematic bonds in our region grow tenfold. Private finance is slowly aligning with climate needs. The new Loss and Damage Fund and its operation present new hopes for financing the most vulnerable. However, climate finance is not happening at the speed and scale needed. It needs to be accessible to developing economies in times of need.

Innovative financing instruments need to be developed and scaled up, from debt-for-climate swaps to SDG bonds, some of which ESCAP is helping to develop in the Pacific and in Cambodia. Growing momentum in the business sector will need to be sustained. The Asia-Pacific Green Deal for Business by the ESCAP Sustainable Business Network (ESBN) is important progress. We are also working with the High-level Climate Champions to bring climate-aligned investment opportunities closer to private financiers.

Lock in higher ambition and accelerate implementation

Climate actions in Asia and the Pacific matter for global success and well-being. The past two years has been a grim reminder that conflicts in one continent create hunger in another, and that emissions somewhere push sea levels higher everywhere. Never has our prosperity been more dependent on collective actions and cooperation.

Our countries are taking note. Member States meeting at the seventh session of the Committee on Environment and Development, which opens today (29 November) are seeking consensus on the regional cooperation needed and priorities for climate action such as oceans, ecosystem and air pollution. We hope that the momentum begun at COP27 and the Committee will be continued at the seventy-ninth session of the Commission as it will hone in on the accelerators for climate action.

In this era of heightened risks and shared prosperity, only regional, multilateral solidarity and genuine ambition that match with the new climate reality unfolding around us — along with bold climate action — are the only way to secure a future where the countries of Asia and the Pacific can prosper.

Armida Salsiah Alisjahbana is an Under-Secretary-General of the United Nations and Executive Secretary of the Economic and Social Commission for Asia and the Pacific (ESCAP)

IPS UN Bureau

 


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UN Assessed Contributions Needed to Generate Core Funding for Climate Loss & Damage

After days of intense negotiations in Sharm el-Sheikh, countries at the latest UN Climate Change Conference, COP27, reached agreement on an outcome that established a funding mechanism to compensate vulnerable nations for ‘loss and damage’ from climate-induced disasters. 20 November 2022 Credit: United Nations

By Inge Kaul
BERLIN, Nov 29 2022 – For decades, there have been non-conclusive deliberations regarding how the international community could support poor and vulnerable countries in their efforts to cope with and recover from the havoc wreaked on their territory by the ill-effects of global warming such as severe droughts, floods, storms, or rising sea levels.

At the COP27 climate summit, this issue figured for the first time as a separate item on the agenda; and, as one of their very last-minute decisions, delegations even agreed to establish a dedicated loss and damage fund (LDF). However, the question of how to operationalize, notably resource the fund was left open.

A “transitional committee” is to be created to examine possible funding options and report to COP28, which could then, eventually, decide on the LDF’s operationalization.

Remembering the many press photos showing the despair written into the faces of people, whose houses and fields were destroyed by floods, or the blank stares of those sitting next to the cadavers of their cattle killed by severe drought conditions,

I feel that business as usual—namely, taking it easy in delivering on funding promises (as we have seen it in the case of the $ 100 billion annual climate-finance promise) — would be an extremely immoral and unethical behavior in the present case.

Therefore, let’s waste no time and start to explore where one could find money fit for the purpose of loss and damage support.

In the following, I argue that only one – still to be established – source will generate on a relatively reliable and predictable manner the longer-term stream of public finance required, as a minimum, for creating a solid basis of LDF core funding.

The funding source to be agreed and established as a matter of highest urgency are UN assessed contributions for climate security.

Money fit for the purpose of loss and damage support

However, at the outset, it is perhaps important to clarify that support for loss and damage should not be confounded with humanitarian assistance delivered as a prompt crisis-response measure.

Disaster may strike countries haphazardly, irrespective of whether they are poor or rich, vulnerable or not. All countries may need or, at least, somehow benefit from immediate and fast-disbursing, short-term humanitarian assistance in cash or kind.

How best to organize such short-term humanitarian assistance is also an important issue that deserves more attention. However, it is an issue beyond the scope of this article.

Therefore, let’s now turn to the specific issue of what type of external support could be most useful for “climate victims”, notably poor and vulnerable countries struggling to rebuild their communities and economies.

An entity such as the newly established LDF and the money that, one day, it might have at its disposal, are governance tools. Like any other tools they should be fit for the purpose at hand.

Considering for now mainly the core funding that the LDF needs to have, it should perhaps have three key characteristics, namely be: (1) public finance; (2) patient, that is, designed for the longer-term; and (3) relatively predictable in its availability.

The reasons are that, typically, a country’s vulnerability to severe climate events is a complex multi-dimensional phenomenon to which both structural factors (e.g., the countries geographic position and size) and non-structural factors (such as its development level) contribute.

Thus, by implication, meaningful loss-and-damage support is likely to be required for several years, maybe, even for a decade or more. This should not come as a surprise, because even in developed countries rebuilding efforts have often been a lengthy process.

Moreover, in the case of small-island developing countries, it could even be that parts of the population need to be resettled to start their life anew.

Initially, patient, predictable public finance may constitute the most important source of funding. As the rebuilding process advances, the public funds could also play an important role in helping to mobilize other resource inflows, including private investments.

Or, they could be twinned with adaptation finance and other types of climate finance, as well as official development assistance.

Making the case for UN assessed contributions for climate-security, including loss and damage support

By now, there exists broad-based agreement that our security today depends on more than the security of our countries’ external borders and on more than the control of within-country conflicts and violence.

As US President Joe Biden, noted in his statement to COP27, military security today is only one dimension of our security, next to climate and food security; and, as COVID-19 taught us, next to global health security.

The security threats we are facing are global in their reach; they tie us together in a web of manifold interdependencies. They require all hands-on deck, or no one will be secure. The United Nations Secretary-General (UNSG) is, therefore, correct in pushing for a “Climate Solidarity Pact.”

Thus, it is timely to ask: Why do we have, within the UN, only an established system of assessed contributions to support efforts aimed at keeping and restoring military security? Why not also assessed contributions – a solidarity-based pact – to climate security?

Among the reasons that strongly speak for this financing option are several. First, such contributions could be introduced for, say, an initial period of 20 years, subject, of course, to regular monitoring of their functioning and impact.

Evidently, they would provide the type of reliable and predictable long-term public finance that the LDF needs.

Second, agreement on a UN funding scale for climate security would help end the present continuous tussle among countries over who should contribute how much. The UN assessment scale for determining individual countries’ contributions to climate security would be based on a joint decision by member states.

Besides income (capacity to pay) one would, in the present case, certainly also consider past and current per-capita emission levels and other relevant factors.

Many aspects of the proposed funding source still need further élaboration and consultations. However, let’s start at the beginning and encourage a world-wide dialogue on the pros and cons of the following issues.

Should we: (1) consider climate security, notably that of vulnerable countries, as a global security issue; and (2) grant climate security the same financing privilege that military security enjoys, namely, to benefit from assessed contributions paid by all UN member states according to a formula that aims at promoting climate security and justice?

Why not ?

Inge Kaul is a fellow at the Hertie School of Governance, Berlin, Germany.

IPS UN Bureau

 


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AGRA Gets Make-Up, Not Make-Over

By Timothy A. Wise and Jomo Kwame Sundaram
BOSTON and KUALA LUMPUR, Nov 29 2022 – Despite its dismal record, the Gates Foundation-sponsored Alliance for a Green Revolution in Africa (AGRA) announced a new five-year strategy in September after rebranding itself by dropping ‘Green Revolution’ from its name.

Rebranding, not reform
Instead of learning from experience and changing its approach accordingly, AGRA’s new strategy promises more of the same. Ignoring evidence, criticisms and civil society pleas and demands, the Gates Foundation has committed another $200 million to its new five-year plan, bringing its total contribution to around $900 million.

Timothy A. Wise

More than two-thirds of AGRA’s funding has come from Gates, with African governments providing much more – as much as a billion dollars yearly – in subsidies for Green Revolution seeds and fertilizers.

Stung by criticism of its poor results, AGRA delayed announcing its new strategy by a year, while its chief executive shepherded the controversial UN Food Systems Summit of 2021. Following this, AGRA has been using more UN Sustainable Development Goals rhetoric.

Hence, AGRA’s new slogan – ‘Sustainably Growing Africa’s Food Systems’. Likewise, the new plan claims to “lay the foundation for a sustainable food systems-led inclusive agricultural transformation”. But beyond such lip service, there is little evidence of any meaningful commitment to sustainable agriculture in the $550 million plan for 2023–27.

Despite heavy government subsidies, AGRA promotion of commercial seeds and fertilizers for just a few cereal crops failed to significantly increase productivity, incomes or even food security. But instead of addressing past shortcomings, the new plan still relies heavily on more of the same despite its failure to “catalyze” a productivity revolution among African farmers.

Jomo Kwame Sundaram

The supposedly new strategy dashes any hopes that AGRA or the Gates Foundation would acknowledge the harmful social and environmental effects of Green Revolutions in India, Africa and elsewhere. AGRA offered no explanation for why it dropped ‘Green Revolution’ from its name.

The name change suggests the 16-year-old AGRA wants to dissociate itself from past failures, but without acknowledging its own flawed approach. Recently, much higher fertilizer prices – following sanctions against Russia and Belarus after the Ukraine invasion – have worsened the lot of farmers relying on AGRA recommended inputs.

It is time to change course, with policies promoting ecological farming by reducing reliance on synthetic fertilizers as appropriate. But despite its new slogan, AGRA’s new strategy intends otherwise.

Last month, the Alliance for Food Sovereignty in Africa rejected the strategy and name change as “cosmetic”, “an admission of failure” of the Green Revolution project, and “a cynical distraction” from the urgent need to change course.

Productivity gains and losses
Despite spending well over a billion dollars, AGRA’s productivity gains have been modest, and only for a few more heavily subsidized crops such as maize and rice. And from 2015 to 2020, cereal yields have not risen at all.

Meanwhile, traditional food crop production has declined under AGRA, with millet falling over a fifth. Yields actually also fell for cassava, groundnuts and root crops such as sweet potato. Across a basket of staple crops, yields rose only 18% in 12 years.

Farmer incomes have not risen, especially after increased production costs are taken into account. As for halving hunger, which Gates and AGRA originally promised, the number of ‘severely undernourished’ people in AGRA’s 13 focus countries increased by 31%!

A donor-commissioned evaluation confirmed many adverse farmer outcomes. It found the minority of farmers who benefited were mainly better-off men, not smallholder women the programme was ostensibly meant for.

That did not deter the Gates Foundation from committing more to AGRA despite its dismal track record, failed strategy, and poor monitoring to track progress. Judging by the new five-year plan, we can expect even less accountability.

The new plan does not even set measurable goals for yields, incomes or food security. As the saying goes, what you don’t measure you don’t value. Apparently, AGRA does not value agricultural productivity, even though it is still at the core of the organization’s strategy.

Last month, the Rockefeller Foundation, AGRA’s other founding donor and a leader of the first Green Revolution from the 1950s, announced a reduction in its grant to AGRA and a decisive step back from the Green Revolution approach.

Its grant to AGRA supports school feeding initiatives and “alternatives to fossil-fuel derived fertilisers and pesticides through the promotion of regenerative agricultural practices such as cultivation of nitrogen-fixing beans”.

Business in charge
AGRA’s new strategy is built on a series of “business lines”, e.g., the “sustainable farming business line” will coordinate with the “Seed Systems business line” to sell inputs. Private Village Based Advisors are meant to provide training and planting advice in this privatized, commercial reincarnation of the government or quasi-government extension services of an earlier era.

The UN Food and Agriculture Organization successfully promoted peer-learning of agro-ecological practices via Farmer Field Schools after successfully field-testing them. This came about after research showed ‘brown hoppers’ thrived in Asian rice farms after Green Revolution pesticides eliminated the insect’s natural predators.

China lost a fifth of its 2007-08 paddy harvest to the pest, triggering a price spike in the thinly traded world rice market. Seeking help from the International Rice Research Institute, located in the Philippines, a Chinese delegation found its Entomology Department had lost most of its former capacity due to under-funding.

Earlier international agricultural research collaboration associated with the first Green Revolution – especially in wheat, maize and rice – seems to have collapsed, surrendering to corporate and philanthropic interests. This bitter experience encouraged China to step up its agronomic research efforts with a greater agro-ecological emphasis.

Empty promises?
The new strategy promises “AGRA will promote increased crop diversification at the farm level”. But its advisers cum salespeople have a vested interest in selling their wares, rather than good local seeds which do not require repeat purchases every planting season.

AGRA is not strengthening resilience by promoting agroecology or reducing farmer reliance on costly inputs such as fossil fuel fertilizers and other, often toxic, agrochemicals. Despite many proven African agroecological initiatives, support for them remains modest.

The new strategy stresses irrigation, key to most other Green Revolutions, but conspicuously absent from Africa’s Green Revolution. But the plan is deafeningly silent on how fiscally strapped governments are to provide such crucial infrastructure, especially in the face of growing water, fiscal and debt stress, worsened by global warming.

It is often said stupidity is doing the same thing over and over again, expecting different results. Perhaps this is due to the technophile conceit that some favoured innovation is superior to everything else, including scientific knowledge, processes and agro-ecological solutions.

IPS UN Bureau

 


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