GWH, GWH.WT EQUITY ALERT: ROSEN, GLOBAL INVESTOR COUNSEL, Encourages ESS Tech, Inc. Investors to Inquire About Securities Class Action Investigation – GWH, GWH.WT

NEW YORK, Jan. 11, 2023 (GLOBE NEWSWIRE) —

WHY: Rosen Law Firm, a global investor rights law firm, continues to investigate securities claims on behalf of shareholders of ESS Tech, Inc. (NYSE: GWH, GWH.WT) resulting from allegations that ESS Tech may have issued materially misleading business information to the investing public.

SO WHAT: If you purchased ESS Tech securities you may be entitled to compensation without payment of any out of pocket fees or costs through a contingency fee arrangement. The Rosen Law Firm is preparing a class action seeking recovery of investor losses.

WHAT TO DO NEXT: To join the prospective class action, go to https://rosenlegal.com/submit–form/?case_id=10877 or call Phillip Kim, Esq. toll–free at 866–767–3653 or email pkim@rosenlegal.com or cases@rosenlegal.com for information on the class action.

WHAT IS THIS ABOUT: On December 7, 2022, Grizzly Research issued a report alleging ESS Tech's partnership with Energy Storage Industries Asia Pacific ("ESI") is not actually a third party but an entity completely reliant on ESS without a real office, staff, or current business. The report alleged that ESS Tech, developer and producer of utility–scale batteries for long duration storage of electricity, concealed its relationship with ESI before announcing their partnership, hid the fact that ESI is a de–facto subsidiary of ESS masking as a third–party client, and misled investors with their partnership announcement to signal business success to investors.

On this news, the price of ESS Tech's shares fell $0.24, or over 7.7%, to close at $2.64 per share on December 7, 2022, damaging investors.

WHY ROSEN LAW: We encourage investors to select qualified counsel with a track record of success in leadership roles. Often, firms issuing notices do not have comparable experience, resources, or any meaningful peer recognition. Many of these firms do not actually litigate securities class actions. Be wise in selecting counsel. The Rosen Law Firm represents investors throughout the globe, concentrating its practice in securities class actions and shareholder derivative litigation. Rosen Law Firm has achieved the largest ever securities class action settlement against a Chinese Company. Rosen Law Firm was Ranked No. 1 by ISS Securities Class Action Services for number of securities class action settlements in 2017. The firm has been ranked in the top 4 each year since 2013 and has recovered hundreds of millions of dollars for investors. In 2019 alone the firm secured over $438 million for investors. In 2020, founding partner Laurence Rosen was named by law360 as a Titan of Plaintiffs' Bar. Many of the firm's attorneys have been recognized by Lawdragon and Super Lawyers.

Follow us for updates on LinkedIn: https://www.linkedin.com/company/the–rosen–law–firm, on Twitter: https://twitter.com/rosen_firm or on Facebook: https://www.facebook.com/rosenlawfirm/.

Attorney Advertising. Prior results do not guarantee a similar outcome.

Contact Information:

Laurence Rosen, Esq.
Phillip Kim, Esq.
The Rosen Law Firm, P.A.
275 Madison Avenue, 40th Floor
New York, NY 10016
Tel: (212) 686–1060
Toll Free: (866) 767–3653
Fax: (212) 202–3827
lrosen@rosenlegal.com
pkim@rosenlegal.com
cases@rosenlegal.com
www.rosenlegal.com


GLOBENEWSWIRE (Distribution ID 8728347)

PHAT INVESTOR NOTICE: ROSEN, RECOGNIZED INVESTOR COUNSEL, Encourages Phathom Pharmaceuticals, Inc. Investors to Inquire About Securities Class Action Investigation – PHAT

NEW YORK, Jan. 11, 2023 (GLOBE NEWSWIRE) — WHY: Rosen Law Firm, a global investor rights law firm, continues its investigation of potential securities claims on behalf of shareholders of Phathom Pharmaceuticals, Inc. (NASDAQ: PHAT) resulting from allegations that Phathom may have issued materially misleading business information to the investing public.

SO WHAT: If you purchased Phathom securities you may be entitled to compensation without payment of any out of pocket fees or costs through a contingency fee arrangement. The Rosen Law Firm is preparing a class action seeking recovery of investor losses.

WHAT TO DO NEXT: To join the prospective class action, go to https://rosenlegal.com/submit–form/?case_id=7943 or call Phillip Kim, Esq. toll–free at 866–767–3653 or email pkim@rosenlegal.com or cases@rosenlegal.com for information on the class action.

WHAT IS THIS ABOUT: On August 2, 2022, before market hours, Phathom issued a press release entitled "Phathom Pharmaceuticals Reports Second Quarter 2022 Financial Results and Provides Business Updates" which announced that "we detected trace levels of a nitrosamine in vonoprazan drug product in our post–approval testing as we prepared for commercial launch." Further, the press release announced that "[t]he Company is working with the FDA and plans to obtain approval of and implement an additional test method, specification, including a proposed acceptable intake limit, and additional controls to address this impurity prior to releasing our first vonoprazan–based products to the market." Finally, Phathom announced that "[t]hese additional activities will result in a delay of the planned VOQUEZNA DUAL PAK and VOQUEZNA TRIPLE PAK product launches."

On this news, Phathom's stock price fell $2.61 per share, or 28%, to close at $6.46 per share on August 2, 2022.

WHY ROSEN LAW: We encourage investors to select qualified counsel with a track record of success in leadership roles. Often, firms issuing notices do not have comparable experience, resources or any meaningful peer recognition. Be wise in selecting counsel. The Rosen Law Firm represents investors throughout the globe, concentrating its practice in securities class actions and shareholder derivative litigation. Rosen Law Firm has achieved the largest ever securities class action settlement against a Chinese Company. Rosen Law Firm was Ranked No. 1 by ISS Securities Class Action Services for number of securities class action settlements in 2017. The firm has been ranked in the top 4 each year since 2013 and has recovered hundreds of millions of dollars for investors. In 2019 alone the firm secured over $438 million for investors. In 2020, founding partner Laurence Rosen was named by law360 as a Titan of Plaintiffs' Bar. Many of the firm's attorneys have been recognized by Lawdragon and Super Lawyers.

Follow us for updates on LinkedIn: https://www.linkedin.com/company/the–rosen–law–firm, on Twitter: https://twitter.com/rosen_firm or on Facebook: https://www.facebook.com/rosenlawfirm/.

Attorney Advertising. Prior results do not guarantee a similar outcome.

———————————————–

Contact Information:

Laurence Rosen, Esq.
Phillip Kim, Esq.
The Rosen Law Firm, P.A.
275 Madison Avenue, 40th Floor
New York, NY 10016
Tel: (212) 686–1060
Toll Free: (866) 767–3653
Fax: (212) 202–3827
lrosen@rosenlegal.com
pkim@rosenlegal.com
cases@rosenlegal.com
www.rosenlegal.com


GLOBENEWSWIRE (Distribution ID 8728345)

ROSEN, RECOGNIZED INVESTOR COUNSEL, Encourages Provident Bancorp, Inc. Investors to Inquire About Securities Class Action Investigation – PVBC

NEW YORK, Jan. 11, 2023 (GLOBE NEWSWIRE) — WHY: Rosen Law Firm, a global investor rights law firm, continues its investigation of potential securities claims on behalf of shareholders of Provident Bancorp, Inc. (NASDAQ: PVBC) resulting from allegations that Provident may have issued materially misleading business information to the investing public.

SO WHAT: If you purchased Provident securities you may be entitled to compensation without payment of any out of pocket fees or costs through a contingency fee arrangement. The Rosen Law Firm is preparing a class action seeking recovery of investor losses.

WHAT TO DO NEXT: To join the prospective class action, go to https://rosenlegal.com/submit–form/?case_id=10252 or call Phillip Kim, Esq. toll–free at 866–767–3653 or email pkim@rosenlegal.com or cases@rosenlegal.com for information on the class action.

WHAT IS THIS ABOUT: On November 15, 2022, Provident filed a Form NT 10–Q Notification of inability to timely file Form 10–Q for the quarter ended September 30, 2022. The Form NT 10–Q stated the delay was due to "estimates that [Provident] will report net loss of approximately $27.5 million for the quarter ended September 30, 2022, compared to net income of $5.1 million for the quarter ended September 30, 2021."

On this news, Provident's stock price fell $2.20, or over 21%, to close on November 16, 2022 at $7.90 on unusually high trading volume.

WHY ROSEN LAW: We encourage investors to select qualified counsel with a track record of success in leadership roles. Often, firms issuing notices do not have comparable experience, resources, or any meaningful peer recognition. Many of these firms do not actually litigate securities class actions. Be wise in selecting counsel. The Rosen Law Firm represents investors throughout the globe, concentrating its practice in securities class actions and shareholder derivative litigation. Rosen Law Firm has achieved the largest ever securities class action settlement against a Chinese Company. Rosen Law Firm was Ranked No. 1 by ISS Securities Class Action Services for number of securities class action settlements in 2017. The firm has been ranked in the top 4 each year since 2013 and has recovered hundreds of millions of dollars for investors. In 2019 alone the firm secured over $438 million for investors. In 2020, founding partner Laurence Rosen was named by law360 as a Titan of Plaintiffs' Bar. Many of the firm's attorneys have been recognized by Lawdragon and Super Lawyers.

Follow us for updates on LinkedIn: https://www.linkedin.com/company/the–rosen–law–firm, on Twitter: https://twitter.com/rosen_firm or on Facebook: https://www.facebook.com/rosenlawfirm/.

Attorney Advertising. Prior results do not guarantee a similar outcome.

Contact Information:

Laurence Rosen, Esq.
Phillip Kim, Esq.
The Rosen Law Firm, P.A.
275 Madison Avenue, 40th Floor
New York, NY 10016
Tel: (212) 686–1060
Toll Free: (866) 767–3653
Fax: (212) 202–3827
lrosen@rosenlegal.com
pkim@rosenlegal.com
cases@rosenlegal.com
www.rosenlegal.com


GLOBENEWSWIRE (Distribution ID 8728306)

CORZ IMPORTANT DEADLINE: ROSEN, TOP RANKED GLOBAL COUNSEL, Encourages Core Scientific, Inc. Investors with Losses in Excess of $100K to Secure Counsel Before Important January 13 Deadline in Securities Class Action – CORZ

NEW YORK, Jan. 11, 2023 (GLOBE NEWSWIRE) — WHY: Rosen Law Firm, a global investor rights law firm, reminds purchasers of the securities of Core Scientific, Inc. (NASDAQ: CORZ) between January 3, 2022 and October 26, 2022, both dates inclusive (the "Class Period"), of the important January 13, 2023 lead plaintiff deadline.

SO WHAT: If you purchased Core Scientific securities during the Class Period you may be entitled to compensation without payment of any out of pocket fees or costs through a contingency fee arrangement.

WHAT TO DO NEXT: To join the Core Scientific class action, go to https://rosenlegal.com/submit–form/?case_id=3932 or call Phillip Kim, Esq. toll–free at 866–767–3653 or email pkim@rosenlegal.com or cases@rosenlegal.com for information on the class action. A class action lawsuit has already been filed. If you wish to serve as lead plaintiff, you must move the Court no later than January 13, 2023. A lead plaintiff is a representative party acting on behalf of other class members in directing the litigation.

WHY ROSEN LAW: We encourage investors to select qualified counsel with a track record of success in leadership roles. Often, firms issuing notices do not have comparable experience, resources or any meaningful peer recognition. Many of these firms do not actually handle securities class actions, but are merely middlemen that refer clients or partner with law firms that actually litigate the cases. Be wise in selecting counsel. The Rosen Law Firm represents investors throughout the globe, concentrating its practice in securities class actions and shareholder derivative litigation. Rosen Law Firm has achieved the largest ever securities class action settlement against a Chinese Company. Rosen Law Firm was Ranked No. 1 by ISS Securities Class Action Services for number of securities class action settlements in 2017. The firm has been ranked in the top 4 each year since 2013 and has recovered hundreds of millions of dollars for investors. In 2019 alone the firm secured over $438 million for investors. In 2020, founding partner Laurence Rosen was named by law360 as a Titan of Plaintiffs' Bar. Many of the firm's attorneys have been recognized by Lawdragon and Super Lawyers.

DETAILS OF THE CASE: According to the lawsuit, throughout the Class Period, defendants made false and/or misleading statements and/or failed to disclose that: (1) due in part to the expiration of a favorable pricing agreement, Core Scientific was experiencing increasing power costs; (2) Core Scientific's largest customer, Gryphon, lacked the financial resources to purchase the necessary miner rigs for Core Scientific to host; (3) Core Scientific was not providing hosting services to Celsius Network LLC and related entities ("Celsius") as required by their contract; (4) Core Scientific had implemented an improper surcharge to pass through power costs to Celsius; (5) as a result of the foregoing alleged breaches of contract, Core Scientific was reasonably likely to incur liability to defend itself against Celsius; (6) as a result of the foregoing, Core Scientific's profitability would be adversely impacted; (7) as a result, there was likely substantial doubt as to Core Scientific's ability to continue as a going concern; and (8) as a result, defendants' statements about its business, operations, and prospects were materially false and misleading and/or lacked reasonable basis at all relevant times. When the true details entered the market, the lawsuit claims that investors suffered damages.

To join the Core Scientific class action, go to https://rosenlegal.com/submit–form/?case_id=3932 or call Phillip Kim, Esq. toll–free at 866–767–3653 or email pkim@rosenlegal.com or cases@rosenlegal.com for information on the class action.

No Class Has Been Certified. Until a class is certified, you are not represented by counsel unless you retain one. You may select counsel of your choice. You may also remain an absent class member and do nothing at this point. An investor's ability to share in any potential future recovery is not dependent upon serving as lead plaintiff.

Follow us for updates on LinkedIn: https://www.linkedin.com/company/the–rosen–law–firm, on Twitter: https://twitter.com/rosen_firm or on Facebook: https://www.facebook.com/rosenlawfirm/.

Attorney Advertising. Prior results do not guarantee a similar outcome.

Contact Information:

Laurence Rosen, Esq.
Phillip Kim, Esq.
The Rosen Law Firm, P.A.
275 Madison Avenue, 40th Floor
New York, NY 10016
Tel: (212) 686–1060
Toll Free: (866) 767–3653
Fax: (212) 202–3827
lrosen@rosenlegal.com
pkim@rosenlegal.com
cases@rosenlegal.com
www.rosenlegal.com


GLOBENEWSWIRE (Distribution ID 8728286)

ROSEN, GLOBAL INVESTOR COUNSEL, Encourages Bird Global, Inc. Investors to Secure Counsel Before Important January 17 Deadline in First Filed Securities Class Action Commenced by the Firm – BRDS

NEW YORK, Jan. 11, 2023 (GLOBE NEWSWIRE) — WHY: Rosen Law Firm, a global investor rights law firm, reminds purchasers of the securities of Bird Global, Inc. (NYSE: BRDS) between May 14, 2021 and November 14, 2022, both dates inclusive (the "Class Period"), of the important January 17, 2023 lead plaintiff deadline in the securities class action commenced by the Firm.

SO WHAT: If you purchased Bird securities during the Class Period you may be entitled to compensation without payment of any out of pocket fees or costs through a contingency fee arrangement.

WHAT TO DO NEXT: To join the Bird class action, go to https://rosenlegal.com/submit–form/?case_id=9805 or call Phillip Kim, Esq. toll–free at 866–767–3653 or email pkim@rosenlegal.com or cases@rosenlegal.com for information on the class action. A class action lawsuit has already been filed. If you wish to serve as lead plaintiff, you must move the Court no later than January 17, 2023. A lead plaintiff is a representative party acting on behalf of other class members in directing the litigation.

WHY ROSEN LAW: We encourage investors to select qualified counsel with a track record of success in leadership roles. Often, firms issuing notices do not have comparable experience, resources, or any meaningful peer recognition. Many of these firms do not actually handle securities class actions, but are merely middlemen that refer clients or partner with law firms that actually litigate the cases. Be wise in selecting counsel. The Rosen Law Firm represents investors throughout the globe, concentrating its practice in securities class actions and shareholder derivative litigation. Rosen Law Firm has achieved the largest ever securities class action settlement against a Chinese Company. Rosen Law Firm was Ranked No. 1 by ISS Securities Class Action Services for number of securities class action settlements in 2017. The firm has been ranked in the top 4 each year since 2013 and has recovered hundreds of millions of dollars for investors. In 2019 alone the firm secured over $438 million for investors. In 2020, founding partner Laurence Rosen was named by law360 as a Titan of Plaintiffs' Bar. Many of the firm's attorneys have been recognized by Lawdragon and Super Lawyers.

DETAILS OF THE CASE: According to the lawsuit, throughout the Class Period, defendants made materially false and/or misleading statements and/or failed to disclose that: (1) Bird was improperly recording Sharing Revenue for certain trips by its customers where collection was not probable; (2) as such, Bird overstated its Sharing Revenue for the relevant quarters and fiscal year during the Class Period; (3) Bird failed to disclose that its internal controls were not effective as they relate to calculating Sharing Revenue recognition; (4) as a result, Bird would need to restate its previously disclosed Sharing Revenue; and (5) as a result, defendants' public statements were materially false and misleading at all relevant times. When the true details entered the market, the lawsuit claims that investors suffered damages.

To join the Bird class action, go to https://rosenlegal.com/submit–form/?case_id=9805 or call Phillip Kim, Esq. toll–free at 866–767–3653 or email pkim@rosenlegal.com or cases@rosenlegal.com for information on the class action.

No Class Has Been Certified. Until a class is certified, you are not represented by counsel unless you retain one. You may select counsel of your choice. You may also remain an absent class member and do nothing at this point. An investor's ability to share in any potential future recovery is not dependent upon serving as lead plaintiff.

Follow us for updates on LinkedIn: https://www.linkedin.com/company/the–rosen–law–firm or on Twitter: https://twitter.com/rosen_firm or on Facebook: https://www.facebook.com/rosenlawfirm.

Attorney Advertising. Prior results do not guarantee a similar outcome.

Contact Information:

Laurence Rosen, Esq.
Phillip Kim, Esq.
The Rosen Law Firm, P.A.
275 Madison Avenue, 40th Floor
New York, NY 10016
Tel: (212) 686–1060
Toll Free: (866) 767–3653
Fax: (212) 202–3827
lrosen@rosenlegal.com
pkim@rosenlegal.com
cases@rosenlegal.com
www.rosenlegal.com


GLOBENEWSWIRE (Distribution ID 8728274)

E.C.D. Automotive Design’s Stunning LT4 Defender Defines Classic Romance

KISSIMMEE, Fla., Jan. 11, 2023 (GLOBE NEWSWIRE) — E.C.D. Automotive Design (E.C.D.) "" the world's largest Land Rover restoration company renowned for its bespoke luxury builds, ranging from classic Defenders to vintage Jaguar E–Types "" delivers Project Sweet Pea, the ultimate love letter in the form of an upgraded vintage Defender 110. Powered by a mighty LT4 engine, the restored Defender's romantic blue finish with white, yellow and silver accents is the perfect addition to charming weekend getaways with your significant other.

"Project Sweet Pea captures the romance of Land Rover Defenders, and designing an entirely unique and upgraded version keeps the magic alive in the 21st century," Co–Founder of E.C.D. Tom Humble said. "Our master craftsmen were able to bring our client's vision to life, and what's more romantic than their partner paying for it?"

With the exterior color matched to a classic blue Ford color "" Project Sweet Pea sits on 16–inch Land Rover HD5 pipe alloy wheels and BF Goodrich All–Terrain tires. Underneath, the old Land Rover Defender has an updated silver steering guard with custom engraving. The LT4 Defender features a Kahn X–Lander grille in the same metallic blue paint with white and yellow accents "" a color scheme the pair maintained throughout the entire build. The original Defender also features a marine–grade LED light bar square in white with clear lenses, strengthened axles and a dual exhaust with one pipe on each side.

The older Defender's pristine white interior is equally breathtaking, with the same light blue and silver accents throughout. The one–of–one restored build features four white heated Recaro Sportster Cross seats with a custom "Sweet Pea" logo embroidered on the headrests and alligator seat inserts in lieu of traditional stitching. Project Sweet Pea also has an extended center console in the middle, with four rear cupholders and two rear Diablo Billet aluminum air–conditioning vents. In the rear, the four jump seats wrapped in Caressa Porcelain leather contrast against the teakwood flooring, which is stained to match the NRG Innovations steering wheel's classic wood grain. Tying the interior together are silver round Billet Buttons across all the upgraded audio additions, including the touchscreen Kenwood eXcelon with CarPlay and an Infinity Kappa sound system. Final touches include five USB ports, four carpeted floor mats and blue seatbelts and seatbacks.

For more information on how to build your own vehicle please visit ecdautodesign.com.

Project Sweet Pea
High–resolution images and video are here.

Model "" Defender 110
Engine "" GM LT4
Transmission "" 8–Speed Automatic
Axles "" Strength
Suspension "" E.C.D. Air Ride
Brakes "" High–Performance ALCON
Exhaust "" Borla Sport Dual Exhaust with one pipe on each side

Exterior
Paint Color "" Ford Brittany Blue Metallic in Gloss with white wing top checkers, wing top air Intakes and side steps
Wheels "" 16" Land Rover HD5 Pipe Alloy with silver lug nuts
Tires "" BF Goodrich All Terrain
Grille "" Kahn X–Lander in Ford Brittany Blue Metallic, white and yellow
Bumper "" ARB Bull Bar with winch
Additional Features "" Marine–grade LED light bar square in white, engraved steering guard with "SHARP," remote–controlled Warn winch, full–length side steps, clear lenses in LED lights

Interior
Seat Layout "" 2+2+4
Front Seats "" Recaro Sportster Cross with seatbacks in Ford Brittany Blue Metallic and custom–embroidered headrests, heated
Midrow Seats "" Recaro Sportster Cross with seatbacks in Ford Brittany Blue Metallic, heated
Load Area Seats "" 4 Inward–facing jump seats
Leather Color "" Caressa Porcelain with Chatham Navy Accents
Seat Design "" Alligator leather seat inserts
Dash "" Puma wrapped in Caressa Porcelain leather, Chatham Navy passenger grab handle
Carpet "" Auto Carpet Navy Blue
Steering Wheel "" NRG Innovations ST–065 in Classic Wood Grain
Gauges "" Esquire
Additional Features "" Extended center console with 4 mid–section cupholders, Teakwood flooring in cargo with painted wheel wells, blue seatbelts, Diablo with Cap Screws Dual Vane Billet Aluminum A/C Vent, 4 carpeted floor mats

Audio & Electronics
Infotainment "" Touchscreen Kenwood eXcelon
Sound System "" Infinity Kappa speakers and subwoofer with silver accents
Additional Features "" Silver metal round Billet Buttons, 5 USB ports, Bluetooth, CarPlay, Sirius XM, Optimil Heater Vent Controls, back–up camera, blind spot assistance

About E.C.D. Automotive Design
E.C.D. Automotive Design (E.C.D.) is a creator of restored luxury vehicles that combines classic English beauty with modern performance. Each vehicle produced by E.C.D. is fully bespoke, a one–off that is designed by the client through an"immersive"luxury design experience"and hand–built from the ground up in 2,200 hours by master–certified ASE craftsmen. The company was founded in 2013 by three British""petrol heads""whose passion for classic vehicles is the driving force behind exceptionally high standards for quality, custom luxury vehicles. E.C.D.'s global headquarters, known as the""Rover"Dome,""is a 100,000–square–foot facility located in Kissimmee, Fla. that is home to 63 talented craftsmen and technicians, who hold a combined 61 ASE and five master level certifications. E.C.D. has a logistics center in the U.K. where its seven employees work to source and transport 25–year–old work vehicles back to the U.S. for restoration."

Media Contact
Uproar PR for E.C.D. Automotive Design
Christine Skofronick
cskofronick@uproarpr.com

A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/d9b2246f–9f08–4778–9a33–0c3ba6d1db1d


GLOBENEWSWIRE (Distribution ID 8727669)

Zenas BioPharma Announces First Patient Dosed in Phase 3 Clinical Study of Obexelimab for the Treatment of Immunoglobulin G4-Related Disease (IgG4-RD)

Global Phase 3 INDIGO study will evaluate the efficacy and safety of obexelimab in patients with IgG4–RD, a chronic and serious fibroinflammatory disease typically affecting multiple organs

IgG4–RD is the first of several potential disease indications to be pursued for obexelimab given its unique non–depleting, B–cell inhibition

WALTHAM, Mass., Jan. 11, 2023 (GLOBE NEWSWIRE) — Zenas BioPharma, a global biopharmaceutical company committed to becoming a leader in the development and commercialization of immune–based therapies, today announced that the first patient has been dosed in the INDIGO Phase 3 registrational study of obexelimab. The INDIGO study will evaluate the clinical efficacy and safety of obexelimab treatment in the prevention of IgG4–related disease (IgG4–RD) flare. Obexelimab is a high–affinity bifunctional antibody that inhibits B–cell lineages by simultaneously binding to CD19 and FcRIIB, thereby downregulating B–cell activity in patients with autoimmune diseases associated with autoantibodies, such as IgG4–RD.

"IgG4–RD is a chronic and serious fibroinflammatory condition that can affect nearly any organ system and can have a profound impact on many patients, leading to severe organ damage or death," said Hua Mu, M.D., Ph.D., Chief Executive Officer at Zenas. "There are no currently approved treatments for patients living with IgG4–RD. Based upon the promising data from a Phase 2 study of obexelimab in IgG4–RD patients, we are excited to continue to evaluate the potential of obexelimab in the INDIGO study."

About the INDIGO Study

The INDIGO study is a global multicenter, randomized, double–blind, placebo–controlled study enrolling up to 200 adults with active IgG4–RD signs/symptoms (i.e., flare) that require steroid therapy. Patients will be randomized in a ratio of 1:1 to receive either obexelimab or placebo, administered as subcutaneous injections.

The primary endpoint of INDIGO is time to first IgG4–RD flare (defined as the reappearance of previous signs/symptoms or appearance of new signs/symptoms of IgG4–RD) that requires initiation of rescue therapy from randomization to Week 52. Safety will be evaluated throughout the study duration.

More information on the INDIGO study (NCT05662241) is available at clinicaltrials.gov.

About Obexelimab

Obexelimab is an investigational Phase 3–stage, novel bifunctional antibody with first–in–class potential that inhibits B–cell lineages that express CD19. Simultaneous binding to CD19 and FcRIIB by obexelimab mimics a natural antigen–antibody complex and downregulates B cell activity. In several early–stage clinical studies, 198 subjects were treated with obexelimab. In these clinical studies, the molecule demonstrated effective inhibition of B cell function without depleting the cells and generated an encouraging treatment effect in patients with multiple autoimmune diseases. Zenas acquired exclusive worldwide rights to obexelimab from Xencor, Inc.

About IgG4–RD

IgG4–RD is a chronic and serious fibroinflammatory disease typically affecting multiple organs (e.g., pancreas, liver, kidney, bile duct, salivary and lacrimal glands). Approximately 20,000 people are diagnosed with IgG4–RD in the US, with similar prevalence rates across geographies. Many patients have some degree of irreversible organ damage at the time of diagnosis. Although nearly all patients initially respond to glucocorticoid (GC) therapy, a majority of patients will relapse/flare within a few months of discontinuing treatment, requiring rescue therapy. Chronic GC therapy is also associated with toxicity in many patients.

About Zenas BioPharma

Zenas BioPharma is a global biopharmaceutical company committed to becoming a leader in the development and commercialization of immune–based therapies for patients around the world. With clinical development and operations globally, Zenas is advancing a deep and balanced global portfolio of potential first– and best–in–class autoimmune therapeutics in areas of high unmet medical need while meeting the value requirements of the dynamic global healthcare environment. The company's pipeline continues to grow through our successful business development strategy. Our experienced leadership team and network of business partners drive operational excellence to deliver potentially transformative therapies to improve the lives of those living with autoimmune and rare diseases. For more information about Zenas BioPharma, please visit www.zenasbio.com and follow us on Twitter at @ZenasBioPharma and LinkedIn.

Investor and Media Contact:
Joe Farmer, President & COO
Zenas BioPharma
IR@zenasbio.com


GLOBENEWSWIRE (Distribution ID 8727743)

Security Policy is more than Defence with Weapons

2022 Year in Review: As conflicts rage, international dialogue remains ‘the only hope’ for peace. Russia’s invasion of Ukraine creating global upheaval, and war, conflict, and unrest blighting all parts of the world in 2022. The UN stressed the importance of international dialogue, and announced plans for a new peace agenda. Credit United Nations

By Herbert Wulf
DUISBURG, Germany, Jan 11 2023 – If our societies are to become resilient and sustainable, our priorities must change towards de-escalation, including in diplomacy and economy.

Putin’s war against Ukraine has not only damaged the international cooperative security architecture, it has permanently destroyed it. The Helsinki Act of 1975, the Charter of Paris of 1990 and the NATO-Russia Founding Act of 1997 created a basis for security cooperation in Europe – even ‘a new era of democracy, peace and unity’, as the Charter of Paris was euphorically titled. At least, that is how the heads of state saw it in the decade after the end of the Cold War.

Today, the war in Ukraine casts a long shadow over European and global security. Cooperation and collaboration have been replaced by military confrontation. Economic cooperation has been shattered, fear of dependency in the energy sector has led to a turning point and the concept of the positive effect of economic interdependence (‘change through trade’) has proven to be a misperception not only in the case of Russia but also with respect to the relationship of the USA and its Asian and European allies against China.

On the contrary, the turn towards confrontational, essentially military-based defence policies can be felt all over the world. Global military spending is at an all-time high of over two trillion US dollars.

Given the budget announcements for the next few years, this sum will continue to rise rapidly in the future. Nuclear weapons have come back into focus. After Russia’s surprising attack, which was hardly considered possible, it is understandable that now – as a first reflex – arms are being upgraded, that economic dependencies are being reduced and, of course, there are concerns about critical infrastructure.

It is not only about traditional military threats. The boundaries between war and peace have become blurred. Hybrid warfare, the use of mercenaries, cyber warfare, destruction of critical infrastructure, undermining social cohesion with disinformation campaigns and election interference, sanctions and other measures of economic warfare have become the standard of international conflict.

De-escalation on three levels

Is there a way out of the constant political, economic and above all military escalation? Despite the apparent hopelessness of an end to the power struggle with Putin, despite the escalated situation in East Asia, despite the many now less noticed wars and conflicts – be it Yemen, Syria, Afghanistan or Mali – it is necessary to think about the possible end of these wars. This should happen in parallel on three levels: security, diplomacy and economy.

With all understanding for the hectic procurement of new weapons now being commissioned in the sign of the turn of the times, it should be noted that security policy is more than defence with weapons. Even if there is currently no path in sight for a negotiated solution to the Ukraine war, such a solution should still be considered.

Ultimately, this war can only be ended through agreements at the negotiating table. Even though Russia started the war in Ukraine in violation of international law and is obviously committing war crimes, in the long term there can be no peace in Europe without Russia and certainly not against Russia.

Respect for Russian security interests, however difficult this may be because of Russian aggression and Putin’s fantasy ideas of Russia, is a prerequisite for de-escalation and serious negotiations.

Geopolitics that maximises only one’s own advantages leads to a dangerous dead end: the clash is pre-programmed.

Many countries rely on a militarily supported geostrategic foreign policy. China’s assertive military, foreign and economic policies are rightly viewed with concern. But the EU also wants to become militarily autonomous.

The US is trying to find partners for its policy conducted in competition with China. Other powers such as Australia, Japan or India are also positioning themselves in rivalry to China.

Instead of focusing on geopolitics, it is necessary to focus on values (democracy, human rights) and binding rules (international law), even if Putin is blatantly violating international law and ‘democracy’ is a foreign word in China. It is necessary to change the narrative significantly.

‘The West’, which demands rule of law and democracy with rigour, has all too often emphasised these values and principles in a know-it-all manner – ‘the West against the rest’. Often enough, double standards were applied and these values were not observed by ‘the West’ itself, such as in the so-called war on terror and the war in Iraq.

If these principles and projects for democracy and against autocracy are to be convincing, then one must completely abandon the concept of ‘the West’ and try to cultivate partnership-based – and not Euro-centric (or ‘Westro-centric’) – relations with democratic countries. In short, geopolitics that maximises only one’s own advantages leads to a dangerous dead end: the clash is pre-programmed.

Is the sole answer of ‘the West’ to keep the upper hand in the geopolitical competition by military means? Economically, it makes sense to reduce dependencies and diversify supply chains. This cannot be done through radical decoupling, but must be done gradually.

Obviously, the shock of the pandemic, but above all Russia’s possibilities to blackmail by stopping energy deliveries, have changed the priorities a little. But by no means all priorities. At no time since the early 1990s has the military burden on global income been as high as it is today: well over two per cent with a trend towards further increases.

The need for timely disarmament

Should the new era (Zeitenwende) consist only of a return to old-fashioned patterns of the military-supported use of force? Arms control is not taking place at the moment. The United Nations and other arms control forums have been pushed to the side. But arms control and de-escalation must already now be considered, even if the Kremlin is still opposed to them and the Chinese leadership is hardly responsive to them at present.

The continuation of the current course leads globally to a situation that is becoming more dangerous than the confrontation in the heyday of the Cold War, since the world is now also seriously endangered by the climate crisis.

Almost all arms exports are accounted for by the G20 and 98 per cent of nuclear warheads are stored in their arsenals.

Although the risks of climate change and armament are well known, there is currently no reversal of this trend in sight. The two crises are heading towards a seemingly unavoidable catastrophe. After the old-world order – with a halfway functioning multilateralism, compromises and give-and-take – was replaced by nationalist aspirations, which then led to a breach of international law in the case of Russia, by an emphasis on nuclear weapons and by the pursuit of supposed self-interest, the goals of the climate agreements are being missed and arms control treaties are being ground down.

Geopolitically ambitious powers such as China, India, Turkey, Brazil, South Africa or Saudi Arabia must be integrated into arms control efforts. Almost ‘naturally’, the G20 summits offer themselves as a forum for this.

The G20 initially focused their talks primarily on macroeconomic issues, but have since also negotiated on sustainable development, energy, the environment and climate change – but not seriously on global security policy.

However, the G20 member countries are responsible for 82 per cent of global military spending. Almost all arms exports are accounted for by the G20 and 98 per cent of nuclear warheads are stored in their arsenals. Today’s military-based arms efforts are concentrated in the G20.

Since the members of this exclusive G20 club are also the main perpetrators of climate change, they bear the main responsibility for the two current catastrophic trends.

Moreover, there are links between climate and arms policy that are most clearly reflected in the wars and violent conflicts of the last decades, the movements of refugees, migrant flows and corresponding counter-reactions.

If our societies are to become more resilient and more ecologically sustainable, then priorities must be changed, and then such a large share of resources cannot be permanently poured into the military – without any prospect of de-escalation. Our current shift must therefore contain more than the present rearmament.

Since the members of this exclusive G20 club are also the main perpetrators of climate change, they bear the main responsibility for the two current catastrophic trends. So, it is time to remind them of their responsibility and urge them to turn back. Perhaps the fact that India is chairing the G20 this year can be used to put security policy prominently on the forum’s agenda.

After all, India has refused to adopt Western sanctions against Russia, citing its own interests. In doing so, the government in Delhi – similar to some other countries in the G20 group (Brazil, South Africa and Turkey) – has kept an open door for potential talks. In order to enable a turning point towards a global security order and cooperation in the climate crisis, more is needed than the current clear military positioning of ‘the West’ in confrontation with Russia.

It is to be hoped that the leading powers of the Global South will strive for a rules-based, multilateral world order within the framework of the G20 talks. That there are possibilities for a security order that looks beyond Europe, as hinted at by Indian Foreign Minister Jaishankar, when he confidently stated: ‘Europe’s problems are the world’s problems, but the world’s problems are not Europe’s.’

Herbert Wulf, Director of the Bonn International Center for Conversion (BICC) from its foundation in 1994 until 2001, is currently a Senior Fellow at BICC and an Adjunct Senior Researcher at the Institute for Development and Peace, University of Duisburg/Essen where he was previously a Deputy Director.

Source: Source: International Politics and Society (IPS)-Journal published by the International Political Analysis Unit of the Friedrich-Ebert-Stiftung, Hiroshimastrasse 28, D-10785 Berlin

IPS UN Bureau

 


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An Oil Tanker Grounded Off Yemen Faces a Potential Humanitarian Disaster

The FSO Safer, moored off Yemen’s west coast. Credit: UNRCO Yemen

By Thalif Deen
UNITED NATIONS, Jan 11 2023 – The long-delayed salvaging of an abandoned tanker, the FSO Safer off the Yemeni coast, has been described as a humanitarian disaster waiting to happen.

The rusting vessel, according to the UN, has remained anchored for more than 30 years. But off-loading and maintenance of the vessel ceased back in 2015, following the start of a devastating civil war in Yemen.

Greenpeace International Project lead Paul Horsman told IPS: “We are staring a major disaster in the face.”

It is unacceptable, he argued, that UNDP, the UN body in charge of facilitating the Safer salvage operations, is creating delays through their internal bureaucracy, potentially adding massive increase in costs, jeopardising an agreement that took years of negotiations to reach, and putting at risk people of Yemen and the Red Sea.

For over a year, everyone has been warning of the imminent danger presented by the Safer. The solution is clear, the technology and expertise are available, ready and able, and the money is there, he added.

“If the Safer leaks or, worse, explodes, it is the UNDP that will carry the blame. They should just get out of the way and allow those who do know what they are doing to get on with the job,” declared Horsman.

Asked for a response, Russell Geekie, Senior Communications Advisor to the UN Resident and Humanitarian Coordinator for Yemen, told IPS under the leadership of the UN Resident Coordinator, UNDP has been working with other UN specialized agencies and partners to urgently implement the UN-coordinated plan to prevent a massive oil spill from the FSO Safer, off Yemen’s Red Sea coast.

The salvage operation, he said, will take place within the context of the crisis in Yemen, which greatly complicates the work to prepare and implement the operation.

“The salvage operation can only begin once a suitable vessel is in place to receive the oil from the FSO Safer”.

At present, he said, the main challenge to the start of the operation is the limited availability of suitable vessels to store the oil. The price in the global market for these vessels has sharply increased – largely as a result of the war in Ukraine.

“UNDP is working with a maritime broker and other partners to find the most suitable solution, fast-tracking processes whenever possible”, he added.

At a UN press briefing last September, David Gressly, UN Resident and Humanitarian Coordinator for Yemen, said the long-delayed salvage operations can begin, now that more than $75 million had been pledged to carry out the vital operation.

The briefing, on the sidelines of the UN General Assembly. was co-hosted by partners in the proposed rescue effort, namely, the Netherlands, the United States, and Germany.

Gressly said that once the pledges are fully converted into cash for the initial salvage operation, with more than $77 million promised from 17 countries, an extra $38 million was still needed for phase two – the installation of safe replacement capacity to secure the one million barrels of oil on board.

The UN plan is for this to be done through transferring the oil to a secure double-hulled vessel, as a permanent storage solution, until the political situation allows it to be sold or transported elsewhere, said Gressly.

But Greenpeace International has remained sceptical because the issue of the FSO Safer, it says, should have been dealt with months ago, before weather conditions deteriorated.

Last autumn, all seemed set fair for the salvage operation, and Smit Boskalis, one of the world’s most experienced salvage companies, was all set to get the operation underway, Greenpeace said.

“But this momentum appears to have now ground to a halt as the UNDP, who are supposed to be coordinating the operation, are creating serious and more expensive delays through their internal bureaucratic processes”.

Greenpeace said it has been campaigning for over two years to get the UN to deal with the FSO Safer and avoid a devastating oil spill in the area.

“We understand the UN FINALLY has the money, but UNDP (who are supposed to be coordinating the multi-donor effort but have no expertise in the oil/shipping issue) are going through internal bureaucratic processes which are creating serious delays and more expense due to daily inflating costs,” Greenpeace said.

According to the UN, fears have grown that unless the vessel is secured, it could break apart causing a devastating oil spill and other environmental damage, which the UN estimates would cost at least $20 billion just to clear up, as well as devastate the fragile economy of war-torn Yemen – triggering a humanitarian catastrophe.

Geekie said donors have generously deposited $73.4 million for the project, with another $10 million pledged. While preparatory work has begun, additional funds are still needed to fully implement the operation, which has the support of both the Government of Yemen in Aden and the Sana’a authorities.

Ensuring that the right team of experts is in place is critical to the operation’s success.

He said UNDP has already procured all the services of relevant experts and operational partners including a top-rated marine management consultancy company, a salvage operation company, a shipbroker, a maritime legal firm, an insurance broker company and oil spill experts for contingency planning to support this crucial mission.

Other UN agencies are also providing technical support to the operation.

Given the high potential environmental and humanitarian risks, the United Nations, including UNDP, is sparing no effort to address the challenges faced off the coast of Yemen and is dealing with this situation with the utmost urgency, he declared.

IPS UN Bureau Report

 


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Cuban Innovator Drives Sustainable Energy Solutions – VIDEO

By Luis Brizuela and Jorge Luis Baños
HAVANA, Jan 11 2023 – Félix Morffi supports the energy needs of his home with the help of the sun, in some cases through handcrafted solutions that make the most of an alternative source that is abundant in Cuba, but still used very little.

With two tanks, glass, aluminum sheets, as well as cinderblocks, sand and cement, the 86-year-old retiree created, in 2006, a solar heater that meets his household needs.

“You build it today and tomorrow you have hot water; anyone can do it, and if they have a bit of advice, all the better,” said the retired mid-level machine and tool repair technician who lives in the municipality of Regla, one of the 15 that make up Havana.

 

 

He also designed and made a dryer that uses the heat of the sun to dehydrate fruits, spices and tubers, which he assembled mostly with recycled products such as pieces of wood, nylon, acrylic and aluminum sheets.

On the roof of his house, 16 solar panels imported in 2019 provide five kilowatts of power (kWp) and help run his small automotive repair shop where he works on vehicles for state-owned companies and private individuals, an independent enterprise that he set up next to his house.

The innovator believes that despite the economic conditions, with a little ingenuity people can take advantage of the natural elements, because “the sun shines for everyone; the wind is there and costs you nothing, but your wealth is in your brain”

In addition to covering his household needs, he provides the surplus electricity to the national grid, the National Electric Power System (SEN).

Morffi said more training is needed among personnel involved in several processes, and he cited delays of more than a year between the signing of the contract with Unión Eléctrica and the beginning of payments for the energy surpluses provided to the SEN, as well as “inconsistency with respect to the assembly” of the equipment.

Although Cuba has a national policy on renewable energy sources, “there is still a lot of ignorance and very little desire to do things, and do them well. Awareness-raising is needed,” he argued.

The innovator believes that despite the economic conditions, with a little ingenuity people can take advantage of the natural elements, because “the sun shines for everyone; the wind is there and costs you nothing, but your wealth is in your brain.”

In his backyard, a small solar panel keeps the water flowing from a well for his barnyard fowl and an artificial pond holding a variety of ornamental fish as well as tilapia for family consumption.

The construction of a small biodigester, about four cubic meters in size, is also at an advanced stage on his land, aimed at using methane gas from the decomposition of animal manure and crop waste, for cooking.

Morffi, who manages these activities with the backing of several family members, also plans to import three small wind turbines of 0.5 kWp each and a new batch of 4 kWp solar PV panels.

His vision is to turn his house into a space for the production and promotion of renewable energies in Cuba.

To this end, he has the support of the non-governmental Cuban Society for the Promotion of Renewable Energy Sources and Respect for the Environment (Cubasolar), of which Morffi has been a member since 2004.

Since 2014, Cuba has had a Policy for the Development of Renewable Energy Sources and their Efficient Use. And in 2019, Decree Law 345 established regulations to increase the share of renewables in electricity generation and steadily decrease the proportion represented by fossil fuels.

According to studies, this archipelago of more than 110,800 square kilometers with an annual average of 330 sunny days receives an average solar radiation of more than five kilowatts per square meter per day, considered to be a high level that provides enormous potential in terms of energy.

The solar energy program appears to be the most advanced and with the best opportunities for growth. Over the last decade, several solar parks have been built, providing more than 75 percent of the renewable energy produced locally.

But clean sources account for just five percent of the island’s electricity generation, an outlook that the authorities want to radically transform, setting an ambitious goal of 37 percent by 2030.