Keyron appoints new Chief Executive Officer

LONDON, Feb. 07, 2023 (GLOBE NEWSWIRE) — Today Keyron, the medical technology group focused on reversing type 2 diabetes, non–alcoholic steatohepatitis (NASH), and obesity via an innovative medical device platform, announced the appointment of Carl D Francis as Chief Executive Officer.

"The continuing rise in obesity, diabetes, and all forms of fatty liver disease is one of the biggest health challenges the world faces today. Literally billions of people are affected, and the numbers continue to rise rapidly," Francis said. "Keyron's technology is a complete game–changer. An innovative, non–surgical, endoscopically–delivered, fully reversible treatment as an alternative to drastic bariatric surgeries is as exciting as it gets. I am really proud and honoured to be part of Keyron."

The American Diabetes Association states that today 37m Americans suffer from diabetes, with 96m having pre–diabetes. The link between obesity and diabetes is well established, and according to The World Obesity Federation's forecast in their recently released 2022 Atlas, 67% of women and 51% of men in the Americas will be living with obesity (BMI 30) by 2030.

Keyron's patented technology is designed to be a fully endoscopic, outpatient procedure providing the same or greater metabolic benefits of gastric bypass surgery, including a reversal of type 2 diabetes and obesity, as well as NASH and liver fibrosis.

Following successful rodent studies in 2019 and swine studies in 2022, Keyron's first–in–human trials are planned to begin in early 2024. Keyron is targeting to achieve FDA clearance by 2028, and a US launch is planned as the first target market. The company is now making plans to raise a $15m Series A funding round.

Dr Giorgio Castagneto Gissey, Keyron's Chairman, said, "We are thrilled that Carl will be leading Keyron as we enter this critical stage of our development. Carl brings energy, focus, and senior leadership experience to ensure we realize our full potential. Keyron has always had high profile, world–leading board members and medical advisors, and we continue to bring onboard remarkable people. We are truly delighted to have been able to attract Carl."

Francis was previously CEO of successful nano–technology group P2i. During his tenure the group grew from a handful of employees to global leadership in the functional nano–coating space. He was most recently CEO of UK–based medtech group Eyoto which specializes in advanced technologies in the optical and ophthalmic industries. He started his career as a US CPA, is a member of Mensa, and has a BSc from the University of Cincinnati.

CONTACT

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ABOUT KEYRON

Keyron is a UK–based, preclinical–stage medical device and technology platform company aimed at a highly–effective treatment of metabolic diseases. Keyron's patented ForePass is an innovative medical device designed to safely reverse type–2 diabetes, as well as NASH, and obesity. The company has already demonstrated a full reversal of insulin resistance in animal studies, and recently published the results in The Lancet EBioMedicine. Keyron has upcoming clinical trials in South America and aims to then carry out further clinical trials in the USA. Its founders, directors, advisors and investors include some of the most well–known and cited professors and KOLs worldwide in the metabolic diseases space. The company is backed by multiple institutional investors based in the USA and EMEA.


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Bhutan’s Civil Servants are Building a Digital Government System — Here’s How

Credit: United Nations

By Amy Shelver and Ian Richards
GENEVA, Switzerland, Feb 7 2023 – New UNCTAD software does to digital government what IKEA did to furniture, allowing Bhutan’s government employees to create their own user-friendly services for citizens online.

Tedious government procedures aren’t just a pain for users, they’re a bore for the civil servants who administer them. Sitting behind a counter and stamping forms isn’t exactly a dream job.

This is where technology can help. In 2021, amid the COVID-19 pandemic, the Bhutanese government launched the G2B digital government portal. It’s a ground-breaking piece of software that earned the country recognition as the fastest place in the world to start a new business.

Entrepreneurs simply fill out a form on their mobile phones, and receive all registration documents at no cost, in less than a minute. In 2022, 5,500 Bhutanese, almost 1% of the population, used the service to register a business – 52% of them were women. It’s also a turning point for Bhutan’s public administration and for the world of digital government in general.

The fastest business registration service on Earth wasn’t designed by consultants in India or California but by the very civil servants who had previously administered the time-consuming, paper-only process that required citizens to go from one government office queue to another.

How did this happen?

Keep it simple

It’s all down to the low-code simplicity of the UNCTAD digital government platform, which after some basic training, Bhutan’s civil servants were able to customize themselves to create online services. The coverage of these services is now vast and includes permits to run bus services, authorizations to fly drones and leases for industrial parks.

Over the next two years, the government plans to include all permits, authorizations and procedures related to the country’s economy in the platform. With time it could stretch across all government departments.

“The goal of our technology is to ease friction,” says Frank Grozel, who heads UNCTAD’s digital government platform programme. “Everyone wins from having effective, uncomplicated technology at their fingertips. But this is especially important for civil servants, because it allows them to focus on why they do their job and not necessarily how they do it.”

Better service delivery

Each service is built from the bottom up. Government teams, including civil servants working on the procedure, developers and trainers came together to simplify existing steps, creating shortcuts that help accelerate service delivery.

Employees are guided to understand the process from the user’s point of view, generating empathy and understanding of where the bottlenecks and frustrations can be.

“Whole teams have started to see how the system could be changed, and why elements of the original process could have felt so painful to the end user,” said Bita Mortazavi, UNCTAD’s project manager for the Bhutan initiative.

The impact on staff has been transformative. “We can now focus on service development and select simple services, with large impact, to change entire systems,” said Sonam Lhamo, project lead at Bhutan’s Ministry of Economic Affairs.

Tshering Dorji, a developer, said it changed his perspective in software development. “My imagination improved a lot. I learned how to simplify without coding,” he said.

Another developer, Pema Gyalpo, was pleasantly surprised.

“We can further simplify even the simple things,” he said. “The experience of building this easier system was not about work, but how we’re going to work [in the future]. I’ll be privileged to send ideas which will serve other countries.”

Innovate first, regulate later

Most Bhutanese businesses are small. About 95% of them are cottage enterprises. This reality drove the country’s government to seek ways to help the mountain nation’s micro-enterprises succeed in the quickest, simplest way.

“Our approach is to innovate first, regulate later, so as to reduce entry barriers for new businesses, embrace innovation and allow creativity to flourish,” said Bhutan’s minister of economic affairs, Tengye Lyonpo.

This ethos has delivered results for the country whose unconventional approaches are working for it and its citizens in novel ways.

While Bhutan has been pioneering the flatpack approach to digital government, making services modular and easier to create, thanks to funding from the Netherlands, other countries are set to follow. Colombia, Estonia, Jordan, Lebanon, Libya, Sudan, Togo and Tunisia will join the club this year.

Countries already benefiting from the platform include Argentina, Benin, Burundi, Cameroon, Cuba, El Salvador, Guatemala, Iraq, Lesotho and Mali.

Amy Shelver is an expert on digitalization and the creative economy and Ian Richards is an economist at UNCTAD specializing in digital business environments.

IPS UN Bureau

 


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NGOs Campaign for a Torture-Free UN Trade Treaty

Credit: Torture Museum, Amsterdam, via Wikipedia

By Thalif Deen
UNITED NATIONS, Feb 7 2023 – Hinting at “Western hypocrisy”, a senior UN official once told a group of reporters, perhaps half-jokingly: “When you go on one of those sight-seeing tours in Europe, they will show you their palaces and castles– but never their medieval prisons or torture chambers.”

The world’s torturers, according to Western nations, were mostly in countries such as Iraq, Afghanistan, Syria and in authoritarian regimes of the Middle East -– with a notoriety for whip lashes, blind folds, leg irons, electric shock devices and public hangings.

In more recent years, torture and water-boarding were common forms of punishment in US-run Guantanamo Bay, in the Abu Ghraib prison in US-occupied Iraq and at the Bagram American air base in Afghanistan.

And in the heart of Amsterdam are a “Torture Museum” and a “Museum of Medieval Torture Instruments” displaying some of the equipment of a bygone era.

Last month, the London-based Amnesty International led a coalition of over 30 civil society organizations (CSOs) calling for a treaty to control the trade in tools of torture used to suppress peaceful protests and abuse detainees around the world.

Dr. Simon Adams, President and CEO of the Center for Victims of Torture, the largest international organization that treats survivors and advocates for an end to torture worldwide, told IPS it’s sickening and outrageous that even though torture is illegal everywhere, at all times, and in all circumstances, more than 500 companies from 58 countries are still manufacturing, marketing and selling goods used in torture on the world market.

“It’s time to strictly regulate goods that are deliberately misused by some security forces to commit torture, and to impose a global ban on goods that have no use other than torture.”

“We need to outlaw this immoral trade in unspeakable human suffering. The UN General Assembly is our global parliament, and international law obligates states to help prevent torture”.

So, the General Assembly should immediately move towards the adoption of a Torture-Free Trade Treaty and prohibit people and companies from profiting from torture,” he noted.

In the declaration signed in London January 20, the civil rights organizations (CSOs) launched a campaign calling for a treaty to prohibit the manufacture and trade in inherently abusive equipment such as spiked batons and body-worn electric shock devices, as well as the introduction of human rights-based controls on the trade in more standard law enforcement equipment, such as pepper spray, rubber bullets and handcuffs.

These items are often used to commit acts of torture or other ill-treatment, which are categorically prohibited under international law, the coalition said.

Asked whether such a treaty should originate at the United Nations, Verity Coyle, Amnesty International’s Law & Policy adviser, told IPS: “Yes, Amnesty International around the world is campaigning for a Torture-Free Trade Treaty through our Flagship Campaign – Protect the Protest.

When the Group of Governmental Experts (GGE) report was published on 30 May 2022, Amnesty published this PR response.

She said the 193-member UN General Assembly (UNGA) is the logical forum given 2019 resolution, including the GGE report recommendations.

The Alliance for Torture-Free Trade (60+ members) is coordinated by the EU, Argentina and Mongolia.

In June 2022, Amnesty was invited to present its analysis of the GGEs report to a meeting of the Alliance “and we continue to hold regular meetings with the EU in particular in anticipation of resolution being brought forward requesting a negotiating mandate”.

Civil Society in Latin America, Coyle pointed out, is speaking regularly to Argentina about the process.

“Our Sections around the world are about to embark on a series of lobby meetings in capitals”, said Coyle, who sits on the global Steering Committee of the Campaign to Stop Killer Robots, of which Amnesty International is a member.

In September 2017, the EU, Argentina and Mongolia launched the Alliance for Torture-Free Trade at the margins of the UN General Assembly in New York.

The Alliance currently comprises over 60 states from all regions of the world pledging to “act together to further prevent, restrict and end trade” in goods used for torture, other ill-treatment and the death penalty.

In June 2019, the UN General Assembly adopted Resolution A/73/L.94, Towards torture-free trade, initiating a process for “examining the feasibility, scope and parameters for possible common international standards” for regulating international trade in this area.

The first stage in this UN process resulted in the July 2020 publication of a UN Secretary General’s study of member states’ positions, which found that the majority of respondent states supported international standards, with most believing these should be through a “legally binding instrument establishing measures to control and restrict trade in goods used for capital punishment, torture or other forms of ill-treatment”.

Meanwhile, the UN Special Rapporteur on “the promotion and protection of human rights and fundamental freedoms while countering terrorism”, Fionnuala Ní Aoláin, is undertaking a “technical visit” to the United States.

Between 6 and 14 February, she will visit Washington D.C. and subsequently the detention facility at the U.S. Naval Station Guantánamo Bay, Cuba.

Over the course of the subsequent three-month period, Ní Aoláin will also carry out a series of interviews with individuals in the United States and abroad, on a voluntary basis, including victims and families of victims of the 11 September 2001 terrorist attacks and former detainees in countries of resettlement/repatriation.

The visit takes place in accordance with the Terms of Reference for Country Visits by Special Procedures Mandate Holders.

Besides Amnesty International, the CSOs campaigning for the treaty include American Civil Liberties Union (ACLU), Article 36, Asia Alliance Against Torture, Association for the Prevention of Torture (APT), Harvard Law School’s International Human Rights Clinic, International Commission of Jurists, International Rehabilitation Council for Torture Victims, The Philippine Alliance of Human Rights Advocates and the Women’s International League for Peace and Freedom (WILPF), among others.

Coyle of Amnesty International also pointed out that equipment, such as tear gas, rubber bullets, batons and restraints, have been used to intimidate, repress and punish protesters, human rights defenders and others, during the policing of demonstrations and in places of detention, in all regions, in recent years.

“Thousands of protesters have sustained eye injuries resulting from the reckless use of rubber bullets, while others have been hit by tear gas grenades, doused in excessive amounts of chemical irritants, beaten with batons, or forced into stress positions by restraints”.

Despite this, there are currently no global human rights-related controls on the trade in law enforcement equipment. However, the UN General Assembly now has a historic opportunity to vote to begin negotiations on a treaty, she declared.

IPS UN Bureau Report

 


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Pact Protecting Environmentalists Suffers Threats in Mexico

A mining waste deposit in the center of the municipality of Topia, in the northern Mexican state of Durango, threatens the air, water and people’s health. The Escazú Agreement, In force since 2021, guarantees access to environmental information and justice in Latin American countries, as well as public participation in decision-making on these issues. CREDIT: Emilio Godoy/IPS

A mining waste deposit in the center of the municipality of Topia, in the northern Mexican state of Durango, threatens the air, water and people’s health. The Escazú Agreement,
In force since 2021, guarantees access to environmental information and justice in Latin American countries, as well as public participation in decision-making on these issues. CREDIT: Emilio Godoy/IPS

By Emilio Godoy
MEXICO CITY, Feb 7 2023 – In the municipality of Papantla, in the southeastern Mexican state of Veracruz, the non-governmental Regional Coordinator of Solidarity Action in Defense of the Huasteca-Totonacapan Territory (Corason) works with local communities on empowering organizations, advocacy capacity in policies and litigation strategies.

“This participation with organizations that work at the national level and have the capacity to influence not only the legal field is important,” Corason coordinator Alejandra Jiménez told IPS from Papantla. “They are able to bring injunctions, and this is how they have managed to block mining projects, for example.”“Up to now, the Escazú Agreement is dead letter, that is the history of many laws in Mexico. Environmentalists have clearly suffered from violence, and let’s not even mention access to information, where there have even been setbacks.” — Alejandra Jiménez

She was referring to the collaboration between locally-based civil society organizations and others of national scope.

Since its creation in 2015, Corason has supported local organizations in their fight against the extraction of shale gas through hydraulic fracturing or fracking, a highly polluting technique that uses large volumes of water and chemicals, in Veracruz and Puebla, as well as mining and hydroelectric plants in Puebla.

Cases like this abound in Mexico, as they do throughout Latin America, a particularly dangerous region for environmentalists.

Activists agreed on the challenges involved in enforcing the Regional Agreement on Access to Information, Public Participation and Justice in Environmental Matters in Latin America and the Caribbean, known as the Escazú Agreement, seen as a tool to mitigate dangers faced by human rights defenders in environmental matters.

A case that has been in the hands of Mexico’s Supreme Court since August 2021 is currently addressing the power of organizations to express their disagreement with environmental decisions and will outline the future of environmental activism in this Latin American country of some 130 million people, and of the enforcement of the Escazú Agreement.

The origin of the case lies in two opposing rulings by Mexican courts in 2019 and 2020, in which one recognized the power of organizations and the other rejected that power. As a result, the case went to the Supreme Court, which must reach a decision to settle the contradiction.

In August 2022 and again on Jan. 25 this year, the Supreme Court postponed its own verdict, which poses a legal threat to the megaprojects promoted by the government of President Andrés Manuel López Obrador, a staunch defender of the country’s oil industry.

Gustavo Ampugnani, general director of Greenpeace Mexico, said the case was an alert to the Escazú Agreement, and that it should not represent a setback for the defense of the environment.

“The significance lies in the risks involved in a wrong decision by the Supreme Court on how to resolve this existing contradiction. If the Court decides that the legal creation of an environmental organization is not enough and that other elements are required, it would limit citizen participation and access to justice,” he told IPS.

Environmentalists are waiting for their Godot in the form of the novel agreement, to which Brazil and Costa Rica do not yet belong, to improve their protection.

The treaty, in force since April 2021 and which takes its name from the Costa Rican city where it was signed, guarantees access to environmental information and justice, as well as public participation in environmental decision-making. It thus protects environmentalists and defenders of local land.

Mexico’s foreign ministry, which represented this country in negotiating the agreement, has identified a legislative route to reform laws that make its application possible and promote the integration of a multisectoral group with that same purpose.

Escazú has been undermined in Mexico by López Obrador’s constant attacks against defenders of the environment, whom he calls “pseudo-environmentalists” and “conservatives” for criticizing his policies, which they describe as anti-environmental and extractivist.

For this reason, a group of organizations and activists requested in a letter to the foreign ministry, released on Feb. 2, details of the progress in the creation of inter-institutional roundtables, selection of indicators, creation of protection mechanisms, and training of officials, including courts, while demanding transparency, inclusion and equity in the process.

Activists from the southern Mexican state of Puebla protest the activities of a water bottling company, on Apr.19, 2021. Environmentalists face serious threats in Mexico, where the Escazú Agreement, which since 2021 provides guarantees to these activists in Latin American countries, has not been applied. CREDIT: Emilio Godoy/IPS

Activists from the southern Mexican state of Puebla protest the activities of a water bottling company, on Apr.19, 2021. Environmentalists face serious threats in Mexico, where the Escazú Agreement, which since 2021 provides guarantees to these activists in Latin American countries, has not been applied. CREDIT: Emilio Godoy/IPS

High risk

In 2021, there were 200 murders of environmentalists around the world, a slight decrease from 227 the previous year, according to a report by the London-based non-governmental organization Global Witness.

Latin America led these crimes, accounting for 157 of the killings, with a slight decline from 165 the previous year. Mexico topped the list with 54 murders, compared to 30 in 2020. Colombia ranked second despite the drop in cases: 33, down from 65 in 2020, followed by Brazil (26 vs. 20), Honduras (eight vs. 17) and Nicaragua (13 vs. 12).

The attacks targeted people involved in opposition to logging, mining, large-scale agribusiness and dams, and more than 40 percent of the victims were indigenous people.

In Mexico there are currently some 600 ongoing environmental conflicts without a solution from the government, according to estimates by the Ministry of Environment and Natural Resources.

The most recent case was the Jan. 15 disappearance of lawyer Ricardo Lagunes and indigenous activist Antonio Díaz, an opponent of mining in the western state of Michoacán, which the United Nations High Commissioner for Human Rights has demanded be urgently clarified.

One year after it came into force, the Escazú Agreement is facing major challenges, especially in countries such as Brazil, Colombia, Guatemala, Honduras, Mexico and Nicaragua, where environmentalists face particular risks.

Olimpia Castillo, coordinator of the non-governmental organization Communication and Environmental Education, said the context sends out a warning.

“It is a very interesting round, because article 10 (of the agreement) refers to highlighting the participation of the organizations. That article could be violated, which would mean a major limitation. These are things that as a country we are going to have to face up to,” the activist, who participated in the negotiation of the agreement as a representative of civil society, told IPS.

In Mexico, compliance with the agreement has already faced hurdles, such as the November 2021 decree by which López Obrador declared his megaprojects “priority works for national security”, thus guaranteeing provisional permits, in contravention of the treaty.

Dispute resolution

Activists are already planning what to do if the Supreme Court hands down a negative verdict: they will turn to the Escazú Agreement dispute resolution mechanism – although the signatory countries have not actually designed it yet.

“We would consider turning to the treaty to resolve the issue. Environmental activism is highly dangerous. But that should not set aside the right of organizations to intervene in decisions. Activists and organizations must be given tools to use regional agreements, because what is happening in the country is very serious,” said Greenpeace’s Ampugnani.

Castillo’s organization is working to raise awareness about the agreement. “If no one knows it exists and that they are obliged to comply with it, how do we make them do it? There are still informative processes in which an application has not yet received a response. We have to demand compliance. There are conditions to apply the agreement. But we need political will to comply with it and to get the word out about it,” she said.

Corason’s Jiménez questioned whether the treaty was up-to-date. “Up to now, the Escazú Agreement is dead letter, that is the history of many laws in Mexico. Environmentalists have clearly suffered from violence, and let’s not even mention access to information, where there have even been setbacks. There is an environment that hinders progress,” she said.

In her view, it is not in the interest of governments to apply the agreement, because it requires participation, information and protection in environmental issues.

In March 2022, the first meeting of the Conference of the Parties to the Escazú Agreement took place, which focused on its operational issues and other aspects that the countries will have to hash out before the next summit is held in 2024.

The Supreme Court, which has not yet set a date for handing down its ruling, is caught between going against the government if it favors environmental organizations or hindering respect for the agreement. For now, the treaty is as far from land as Mexico City is from Escazú: about 1,925 kilometers.