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L'usine de médicaments stériles Curia nommée fabricant de l'année dans le Massachusetts

ALBANY, N.Y., 22 oct. 2025 (GLOBE NEWSWIRE) — Curia Global, Inc. (Curia), une organisation leader dans la recherche, le développement et la fabrication sous contrat, a annoncé aujourd'hui que son usine de produits pharmaceutiques stériles de Burlington, dans le Massachusetts, a été nommée « Fabricant de l'année » par le Massachusetts Legislative Manufacturing Caucus. Le prix a été remis lors de la 10e cérémonie annuelle de remise des prix de fabrication, qui s'est tenue le 21 octobre au stade Gillette.

Le site de Curia à Burlington fait partie du réseau de l’entreprise depuis 2010. L'installation est spécialisée dans la fabrication de produits pharmaceutiques sous forme de flacons et de seringues préremplies destinés aux études cliniques de stade avancé et aux produits commerciaux. Le site est reconnu pour ses capacités à gérer des procédés à base de solvants, des produits hautement visqueux et des substances réglementées. Il abrite également un laboratoire de mise au point des procédés sur site prenant en charge les études de mélange, la mise à l'échelle et la conception de formulations.

« Guidés par les normes de qualité les plus strictes, les employés de Curia jouent un rôle crucial dans la production de médicaments auxquels les patients peuvent faire confiance », a déclaré Mari–Kate Alter, directrice générale et chef de site de Curia Burlington. « Bien que nos clients directs soient des sociétés pharmaceutiques, nous venons travailler chaque jour en pensant aux patients. Nous sommes honorés de contribuer à l’amélioration de la vie des patients et sommes fiers d’être reconnus pour notre rôle dans l’écosystème de fabrication du Massachusetts. »

Les capacités de Curia en matière de produits pharmaceutiques stériles comprennent le travail avec des API complexes, des composés puissants et cytotoxiques, des formulations hautement visqueuses et des substances réglementées, de l'échelle clinique à l'échelle commerciale, dans quatre installations de pointe à travers le monde. Le site de Burlington fait partie du réseau mondial d'installations de remplissage et de finition stériles de Curia, qui comprend la fabrication clinique à Camarillo, en Californie et à Glasgow, au Royaume–Uni, ainsi que des capacités commerciales et cliniques à Albuquerque, au Nouveau–Mexique.

Le Manufacturing Caucus, formé en 2014, comprend plus de 70 législateurs du Massachusetts qui se concentrent sur le renforcement du secteur manufacturier de l'État par le biais de la formation de la main–d'œuvre, du soutien à l'innovation et des programmes d'apprentissage.

« C'est une période passionnante pour les fabricants engagés comme Curia qui incarnent le 'Making It in Massachusetts' », a confié le représentant de l'État Jeffrey Roy, président du caucus manufacturier de la Chambre. « L’industrie manufacturière reste essentielle à notre économie et à notre avenir, offrant innovation et emplois bien rémunérés aux résidents de tout le Commonwealth. Nous sommes impatients de célébrer Curia lors de la 10e cérémonie annuelle de remise des prix de fabrication au stade Gillette, le mardi 21 octobre 2025. »

À propos de Curia
Curia est une organisation de recherche, de développement et de fabrication sous contrat (ou CDMO pour Contract Development and Manufacturing Organization) forte de plus de 30 ans d’expérience à son actif. Elle exploite un réseau intégré de plus de 20 sites à travers le monde et emploie quelque 3 200 collaborateurs travaillant en partenariat avec des clients biopharmaceutiques pour mettre sur le marché des traitements qui changent véritablement la vie des gens. Nos offres en matière de petites molécules, d’API génériques et de produits biologiques couvrent le cycle complet de la découverte à la commercialisation, et intègrent des capacités réglementaires, analytiques et de remplissage et finition stériles. Nos experts en sciences et en processus, ainsi que nos installations conformes à la réglementation, offrent une expérience de premier ordre dans la fabrication de substances et de produits pharmaceutiques. De la curiosité au traitement, nous réalisons toutes les étapes permettant d’accélérer vos recherches et d’améliorer la vie des patients. Consultez notre site à l’adresse curiaglobal.com.

Contact de l’entreprise :
Viana Bhagan
Curia
+1 518 512 2111
[email protected]


GLOBENEWSWIRE (Distribution ID 9550232)

Instalação de Medicamentos Estéreis da Curia Nomeada Fabricante do Ano de Massachusetts

ALBANY, N.Y., Oct. 22, 2025 (GLOBE NEWSWIRE) — A Curia Global, Inc. (Curia), uma organização líder em contratos de pesquisa, desenvolvimento e fabricação, anunciou hoje que sua instalação de medicamentos estéreis em Burlington, MA, foi nomeada “Fabricante do Ano” pelo Comitê de Fabricação Legislativa de Massachusetts. O prêmio foi entregue na 10ª Cerimônia Anual de Premiação de Fabricação, realizada no dia 21 de outubro no Gillette Stadium.

A unidade de Burlington da Curia faz parte da rede da empresa desde 2010. A instalação é especializada na fabricação de produtos farmacêuticos de frascos e seringas pré–cheias para ensaios clínicos em estágio avançado e produtos comerciais. A unidade é conhecida por sua capacidade de lidar com processos à base de solventes, produtos altamente viscosos e substâncias controladas. Também abriga um laboratório de desenvolvimento de processos no local, apoiando estudos de mistura, aumento de escala e desenvolvimento de formulações.

“Os funcionários da Curia têm um papel crucial na produção de medicamentos em que os pacientes podem confiar, guiados pelos mais rigorosos padrões de qualidade”, disse Mari–Kate Alter, Gerente Geral e Chefe de Unidade da Curia Burlington. “Embora nossos clientes diretos sejam empresas farmacêuticas, trabalhamos todos os dias pensando nos pacientes. Nos sentimos honrados em contribuir para melhorar a vida dos pacientes e temos orgulho de ser reconhecidos pelo nosso papel no ecossistema de fabricação de Massachusetts.”

A fabricação de medicamentos estéreis da Curia inclui o trabalho com APIs complexos, compostos potentes e citotóxicos, formulações altamente viscosas e substâncias controladas, de escala clínica a comercial, realizados em quatro instalações avançadas em todo o mundo. A unidade de Burlington faz parte da rede global de instalações de processamento final estéril da Curia, que inclui fabricação clínica em Camarillo, CA e Glasgow, Reino Unido, bem como capacidades comerciais e clínicas em Albuquerque, NM.

O Comitê de Manufatura, criado em 2014, inclui mais de 70 legisladores de Massachusetts focados no fortalecimento do setor manufatureiro do estado por meio de treinamento da força de trabalho, apoio à inovação e programas de aprendizagem.

“Este é um momento empolgante para fabricantes comprometidos como a Curia, que incorpora o ‘Making It in Massachusetts’”, disse o representante estadual Jeffrey Roy, Presidente do Comitê de Manufatura. “A manufatura continua sendo vital para nossa economia e para o futuro, proporcionando inovação e empregos bem remunerados para residentes em toda a Commonwealth. Estamos prontos para celebrar a Curia na 10ª Cerimônia Anual de Premiação de Fabricação no Gillette Stadium na terça–feira, 21 de outubro de 2025.”

Sobre a Curia
A Curia é uma Organização de Desenvolvimento e Fabricação por Contratos (CDMO) com mais de 30 anos de experiência, uma rede integrada de 20 locais em todo o mundo e 3.200 funcionários em parcerias com clientes biofarmacêuticos para lançamento no mercado terapias que mudam a vida. Nossas ofertas de pequenas moléculas, APIs genéricos, produtos de medicamentos estéreis e produtos biológicos resultam em descobertas através da comercialização, com integridade regulatória, de capacidade analítica e processamento final estéril. Nossos especialistas científicos e de processos, juntamente com nossas instalações em conformidade regulatórias, oferecem a melhor experiência em fabricação de medicamentos e produtos farmacêuticos. Da curiosidade à cura, proporcionamos todas as etapas necessárias para acelerar sua pesquisa e melhorar a vida dos pacientes. Visite–nos em curiaglobal.com.

Contato Corporativo:
Viana Bhagan
Curia
+1 (518) 512 2111
[email protected]


GLOBENEWSWIRE (Distribution ID 9550232)

Curias Anlage für sterile Arzneimittel als Hersteller des Jahres in Massachusetts ausgezeichnet

ALBANY, N.Y., Oct. 22, 2025 (GLOBE NEWSWIRE) — Curia Global, Inc. (Curia), ein führendes Auftragsforschungs–, Entwicklungs– und Produktionsunternehmen, gab heute bekannt, dass seine Anlage für sterile Arzneimittel in Burlington, Massachusetts, vom Massachusetts Legislative Manufacturing Caucus zum „Hersteller des Jahres” gekürt wurde. Die Auszeichnung wurde im Rahmen der 10. jährlichen Manufacturing Awards Ceremony verliehen, die am 21. Oktober im Gillette Stadium stattfand.

Der Standort Burlington von Curia gehört seit 2010 zum Netzwerk des Unternehmens. Die Anlage ist auf die Herstellung von Arzneimitteln in Fläschchen und Fertigspritzen für klinische Studien in der Spätphase und kommerzielle Produkte spezialisiert. Der Standort ist bekannt für sein Know–how in Bezug auf lösungsmittelbasierte Prozesse, hochviskose Formulierungen und kontrollierte Substanzen. Er beherbergt außerdem ein eigenes Prozessentwicklungslabor, das Mischstudien, Scale–up und Formulierungsentwicklung unterstützt.

„Die Mitarbeiter von Curia spielen eine entscheidende Rolle bei der Herstellung von Arzneimitteln, denen Patienten vertrauen können, und orientieren sich dabei an strengsten Qualitätsstandards“, so Mari–Kate Alter, Geschäftsführerin und Standortleiterin von Curia Burlington. „Obwohl unsere direkten Kunden Pharmaunternehmen sind, kommen wir jeden Tag mit den Patienten im Hinterkopf zur Arbeit. Wir fühlen uns geehrt, zur Verbesserung der Lebensqualität von Patienten beitragen zu dürfen, und sind stolz darauf, für unsere Rolle im Fertigungsökosystem von Massachusetts anerkannt zu werden.“

Die Kompetenzen von Curia im Bereich steriler Arzneimittel umfassen die Arbeit mit komplexen Wirkstoffen, hochwirksamen und zytotoxischen Verbindungen, hochviskosen Formulierungen und kontrollierten Substanzen, vom klinischen bis zum kommerziellen Maßstab, in vier hochmodernen Einrichtungen weltweit. Der Standort Burlington ist Teil des globalen Netzwerks steriler Abfüllanlagen von Curia, zu dem auch die klinische Produktion in Camarillo (Kalifornien) und Glasgow (Großbritannien) sowie kommerzielle und klinische Kapazitäten in Albuquerque (New Mexico) gehören.

Der 2014 gegründete Manufacturing Caucus umfasst mehr als 70 Gesetzgeber aus Massachusetts, die sich auf die Stärkung des Fertigungssektors des Bundesstaates durch Personalschulungen, Innovationsförderung und Ausbildungsprogramme konzentrieren.

„Dies ist eine spannende Zeit für engagierte Hersteller wie Curia, die das Motto ‚Making It in Massachusetts‘ verkörpern“, so Jeffrey Roy, State Representative und House Chair, Manufacturing Caucus. „Die Fertigungsindustrie ist für unsere Wirtschaft und Zukunft nach wie vor von entscheidender Bedeutung, da sie Innovationen fördert und hochbezahlte Arbeitsplätze für die Einwohner des gesamten Bundesstaates schafft. Wir freuen uns darauf, Curia bei der 10. jährlichen Manufacturing Awards Ceremony am Dienstag, dem 21. Oktober 2025, im Gillette Stadium zu feiern.“

Über Curia
Curia ist ein Auftragsforschungs–, Entwicklungs– und Produktionsunternehmen (CDMO) mit über 30 Jahren Erfahrung, einem integrierten Netzwerk von 20 Standorten weltweit und 3.200 Mitarbeitern, das mit Kunden aus der Biopharmazie zusammenarbeitet, um lebensverändernde Therapien auf den Markt zu bringen. Unser Angebot an niedermolekularen Wirkstoffen, generischen Wirkstoffen, sterilen Arzneimitteln und Biologika umfasst die gesamte Bandbreite von der Entdeckung bis zur Vermarktung, einschließlich integrierter Kompetenzen in den Bereichen Zulassung, Analytik und sterile Abfüllung. Unsere Wissenschafts– und Prozessexperten sowie unsere behördlichen Vorschriften entsprechenden Einrichtungen bieten erstklassige Kompetenz in der Herstellung von Arzneimittelwirkstoffen und –produkten. Von der Neugier bis zur Heilung – wir unterstützen Sie bei jedem Schritt, um Ihre Forschung zu beschleunigen und das Leben von Patienten zu verbessern. Besuchen Sie uns unter curiaglobal.com.

Kontakt zum Unternehmen:
Viana Bhagan
Curia
+1 518 512 2111
[email protected]


GLOBENEWSWIRE (Distribution ID 9550232)

Curia Sterile Drug Product Facility Named Massachusetts Manufacturer of the Year

ALBANY, N.Y., Oct. 21, 2025 (GLOBE NEWSWIRE) — Curia Global, Inc. (Curia), a leading contract research, development and manufacturing organization, today announced its Burlington, MA sterile drug product facility has been named “Manufacturer of the Year” by the Massachusetts Legislative Manufacturing Caucus. The award was presented at the 10th Annual Manufacturing Awards Ceremony, held on Oct. 21 at Gillette Stadium.

Curia’s Burlington site has been part of the company’s network since 2010. The facility specializes in drug product manufacturing of vials and prefilled syringes for late–stage clinical trials and commercial products. The site is known for its capabilities to handle solvent–based processes, highly viscous products and controlled substances. It also houses an on–site process development lab supporting mixing studies, scale–up and formulation development.

“Curia employees play a crucial role in producing medicines patients can trust, guided by the most stringent quality standards,” said Mari–Kate Alter, General Manager and Site Head, Curia Burlington. “While our direct clients are pharmaceutical companies, we come to work each day with patients in mind. We are honored to contribute to improving patient lives and are proud to be recognized for our role in Massachusetts’ manufacturing ecosystem.”

Curia’s sterile drug product capabilities include working with complex APIs, potent and cytotoxic compounds, highly viscous formulations and controlled substances, from clinical to commercial scale, at four advanced facilities around the world. The Burlington site is part of Curia’s global network of sterile fill–finish facilities, which includes clinical manufacturing in Camarillo, CA and Glasgow, UK, as well as commercial and clinical capabilities in Albuquerque, NM.

The Manufacturing Caucus, formed in 2014, includes more than 70 Massachusetts legislators focused on strengthening the state’s manufacturing sector through workforce training, innovation support and apprenticeship programs.

“This is an exciting time for committed manufacturers like Curia who embody ‘Making It in Massachusetts,’” said State Representative Jeffrey Roy, House Chair of the Manufacturing Caucus. “Manufacturing remains vital to our economy and future, providing innovation and high–paying jobs for residents across the Commonwealth. We look forward to celebrating Curia at the 10th Annual Manufacturing Awards Ceremony at Gillette Stadium on Tuesday, Oct. 21, 2025.”

About Curia
Curia is a contract research, development and manufacturing organization (CDMO) with over 30 years of experience, an integrated network of 20 global sites and 3,200 employees partnering with biopharmaceutical customers to bring life–changing therapies to market. Our offerings in small molecule, generic APIs, sterile drug product and biologics span discovery through commercialization, with integrated regulatory, analytical and sterile fill–finish capabilities. Our scientific and process experts, along with our regulatory–compliant facilities, provide a best–in–class experience across drug substance and drug product manufacturing. From curiosity to cure, we deliver every step to accelerate your research and improve patients’ lives. Visit us at curiaglobal.com.

Corporate Contact:
Viana Bhagan
Curia
+1 518 512 2111
[email protected]


GLOBENEWSWIRE (Distribution ID 9549347)

Minovia Therapeutics Receives FDA Orphan Drug Designation for MNV-201 in Myelodysplastic Syndrome

HAIFA, Israel, Oct. 15, 2025 (GLOBE NEWSWIRE) — Minovia Therapeutics Ltd. (“Minovia” or the “Company”), a clinical–stage biotechnology company developing novel therapies to treat mitochondrial diseases and combat age–related decline, announces that the U.S. Food and Drug Administration (FDA) has granted Orphan Drug Designation (ODD) to the Company’s lead investigational compound, MNV–201 for Myelodysplastic Syndrome (MDS), a serious age–related hematopoietic disease. This designation is in addition to the existing FDA Fast Track Designation in MDS, as well as both Fast Track and Rare Pediatric Disease Designations for MNV–201 in the treatment of Pearson Syndrome.

“We continue to receive validation from the FDA for the potential of our lead product, MNV–201, this time in the form of Orphan Drug Designation in MDS. MNV–201 targets the mitochondria, a critical multi–functional organelle. FDA designations such as ODD underscore the urgency of drugs treating these diseases affecting smaller populations, while providing additional benefits across the FDA process that, we expect, will prove both medically and financially valuable,” said Minovia Co–founder and CEO, Natalie Yivgi–Ohana, Ph.D.

“Orphan drug designation for MNV–201 marks an important milestone in our mission to address critical challenges in mitochondrial health in both primary and acquired mitochondrial diseases. By leveraging our expertise in mitochondrial and hematopoietic science, and through the innovative mechanism of action of our drug product, we hope to bring forward a treatment option that could significantly improve outcomes for MDS patients,” added Minovia Chief Scientific Officer, Noa Sher, PhD.

Orphan drug designation is a status granted by the FDA to drugs developed to treat rare diseases affecting fewer than 200,000 people in the U.S. This designation provides various incentives, such as tax credits and market exclusivity, to encourage the development of treatments for conditions that may not be profitable otherwise.

The Company also announced entry into a definitive business combination agreement (the “Business Combination Agreement”) with Launch One Acquisition Corp. (Nasdaq: LPAA, “Launch One”), a publicly traded special purpose acquisition company. Following the expected closing of the transaction contemplated by this Business Combination Agreement (the “Business Combination”), projected for late 2025, the combined company will operate as Minovia Therapeutics and trade on Nasdaq under a new ticker symbol.

About MDS

MDS is defined by ineffective hematopoiesis resulting in blood cytopenia, and clonal instability with a risk of evolution to Acute Myeloid Leukemia (AML). Patients with MDS collectively have a high symptom burden and are also at risk of death from complications of cytopenia and AML. The goals of therapy for patients with MDS are to improve cytopenia, reduce disease–associated symptoms and the risk of disease progression and death, thereby improving both quality of life and lifespan. The median age at diagnosis of MDS is ~70 years, but surprisingly some of the Pearson Syndrome patients develop MDS in a much higher prevalence relative to the disease population. About 15% of the MDS patients will present with Sideroblastic Anemia, the most common symptom in Pearson Syndrome. Minovia developed novel blood biomarkers to measure mitochondrial health and has been able to demonstrate for the first time that MDS is presumably an age–related mitochondrial disease. As such, Minovia is currently conducting a Phase Ib study of MNV–201 in low–risk MDS patients. Six out of the nine expected patients in the study have been dosed so far.

About MNV–201

MNV–201 is a first–in–class cell therapy that uses Minovia’s proprietary Mitochondrial Augmentation Technology (MAT) to add healthy, energy–producing mitochondria into a patient’s own stem cells — aiming to restore organ function and improve health. In early–stage clinical studies, MAT has demonstrated a strong safety profile and signs of multi–system benefit in patients with Pearson Syndrome, including improvements in growth, muscle function, hematologic stability, and improved quality of life.

About Minovia Therapeutics

Minovia Therapeutics, chaired by John Cox, is a clinical–state biotechnology company working on treatments to replace dead or defective mitochondria with new healthy mitochondria, helping people with mitochondrial diseases and fighting aging. Minovia’s main treatment, MNV–201, is already being tested for Pearson Syndrome and Myelodysplastic Syndrome. Minovia is also developing ways to help people live longer, healthier lives. Based in Haifa, Israel, where it operates a GMP facility for mitochondrial drug substance and drug product manufacturing for clinical trials related to its therapy, Minovia is planning to expand operations to the U.S. For more information, visit www.minoviatx.com.

About Launch One Acquisition Corp.

Launch One Acquisition Corp. is a company set up to merge with and take public an exciting business in healthcare or technology. Listed on Nasdaq under the ticker LPAA, Launch One is led by experienced leaders who want to support game–changing solutions. For more information, contact Jurgen van de Vyver at [email protected].

Additional Information and Where to Find It

In connection with the Business Combination and the Business Combination Agreement, among Launch One, Minovia and Mito US One Ltd., a newly formed Israeli company limited by shares (“Pubco”), and certain other parties named therein. Launch One and Minovia intend to file relevant materials with the U.S. Securities and Exchange Commission (“SEC”), including a Registration Statement on Form F–4 of Pubco (the “Registration Statement”), which will include a proxy statement/prospectus of Launch One, and will file other documents regarding the proposed Business Combination with the SEC. This communication is not intended to be, and is not, a substitute for the proxy statement/prospectus or any other document that Launch One has filed or may file with the SEC in connection with the proposed Business Combination. The Registration Statement has not been filed or declared effective by the SEC. Following such filing and upon such declaration of effectiveness, the definitive proxy statement/prospectus contained within the Registration Statement and other relevant materials for the proposed Business Combination will be mailed or made available to stockholders of Launch One as of a record date to be established for voting on the proposed Business Combination.

Before making any voting or investment decision, investors and stockholders of Launch One are urged to carefully read, when they become available, the entire Registration Statement, the proxy statement/prospectus, and any other relevant documents filed with the SEC, as well as any amendments or supplements to these documents, and the documents incorporated by reference therein, because they will contain important information about Launch One, Minovia, Pubco and the proposed Business Combination . Launch One’s investors and stockholders and other interested persons will also be able to obtain copies of the Registration Statement, the preliminary proxy statement/prospectus, the definitive proxy statement/prospectus, other documents filed with the SEC that will be incorporated by reference therein, and all other relevant documents filed with the SEC by Launch One and/or Pubco in connection with the Business Combination, without charge, once available, at the SEC’s website at www.sec.gov, or by directing a request to Launch One or Minovia at the addresses set forth below.

Participants In the Solicitation

Launch One, Minovia, Pubco and their respective directors, executive officers, other members of management and employees may be deemed participants in the solicitation of proxies from Launch One’s stockholders with respect to the Business Combination. Investors and security holders may obtain more detailed information regarding the names, and interests in the Business Combination, of Launch One’s directors and officers in Pubco's and Launch One’s filings with the SEC, including, when filed with the SEC, the preliminary proxy statement/prospectus, the definitive proxy statement/prospectus, amendments and supplements thereto, and other documents filed with the SEC. Such information with respect to Minovia’s directors and executive officers will also be included in the proxy statement/prospectus. You may obtain free copies of these documents as described above under the heading “Additional Information and Where to Find It.”

Non–Solicitation

This press release is not a proxy statement or solicitation of a proxy, consent or authorization with respect to any securities or in respect of the potential transaction and shall not constitute an offer to sell or a solicitation of an offer to buy the securities of Launch One, Pubco, or Minovia, nor shall there be any sale of any such securities in any state or jurisdiction in which such offer, solicitation, or sale would be unlawful prior to registration or qualification under the securities laws of such state or jurisdiction. No offer of securities shall be made except by means of a prospectus meeting the requirements of the Securities Act of 1933, as amended.

Forward–Looking Statements

This press release includes certain statements that may be considered forward–looking statements within the meaning of the federal securities laws. Forward–looking statements include, without limitation, statements about future events or Minovia’s, Launch One's, or Pubco's future financial or operating performance. For example, statements regarding the development and regulatory approval of MNV–201, the implications of Fast Track Designation, RPD and PRVs and the timing of future clinical trials or potential applications are forward–looking statements. In some cases, you can identify forward–looking statements by terminology such as “may,” “should,” “could,” “might,” “plan,” “possible,” “project,” “strive,” “budget,” “forecast,” “expect,” “intend,” “will,” “estimate,” “anticipate,” “believe,” “predict,” “potential” or “continue,” or the negatives of these terms or variations of them or similar terminology.

These forward–looking statements regarding future events and the future results of Minovia or Launch One are based on current expectations, estimates, forecasts, and projections about the industry in which Minovia or Launch One operates, as well as the beliefs and assumptions of Minovia’s and Launch One's management. These forward–looking statements are only predictions and are subject to, without limitation, (i) known and unknown risks, including the risks and uncertainties indicated from time to time in the final prospectus of Launch One relating to its initial public offering filed with the SEC, including those under “Risk Factors” therein, and other documents filed or to be filed with the SEC by Launch One or Pubco; (ii) uncertainties; (iii) assumptions; and (v) other factors beyond Minovia’s or Launch One's control that are difficult to predict because they relate to events and depend on circumstances that will occur in the future. They are neither statements of historical fact nor promises or guarantees of future performance. Therefore, Minovia’s actual results may differ materially and adversely from those expressed or implied in any forward–looking statements and Minovia and Launch One therefore caution against relying on any of these forward–looking statements.

These forward–looking statements are based upon estimates and assumptions that, while considered reasonable by Minovia and its management, as the case may be, are inherently uncertain and are inherently subject to risks, variability and contingencies, many of which are beyond Minovia’s or Launch One's control. Factors that may cause actual results to differ materially from current expectations include, but are not limited to: (i) the occurrence of any event, change or other circumstances that could give rise to the termination of the Business Combination Agreement and any subsequent definitive agreements with respect to the Business Combination; (ii) the outcome of any legal proceedings that may be instituted against Launch One, Minovia, Pubco, or others following the announcement of the Business Combination and any definitive agreements with respect thereto; (iii) the inability to complete the Business Combination due to the failure to obtain consents and approvals of the shareholders of Launch One and Minovia, to obtain financing to complete the Business Combination or to satisfy other conditions to closing, or delays in obtaining, adverse conditions contained in, or the inability to obtain necessary regulatory approvals required to complete the transactions contemplated by the Business Combination Agreement; (iv) changes to the proposed structure of the Business Combination that may be required or appropriate as a result of applicable laws or regulations or as a condition to obtaining regulatory approval of the Business Combination; (v) projections, estimates and forecasts of revenue and other financial and performance metrics, projections of market opportunity and expectations, and the estimated implied enterprise value of Minovia; (vi) Minovia’s ability to scale and grow its business, and the advantages and expected growth of Minovia; (vii) Minovia’s ability to source and retain talent, and the cash position of Minovia following closing of the Business Combination; (viii) the ability to meet stock exchange listing standards in connection with, and following, the consummation of the Business Combination; (ix) the risk that the Business Combination disrupts current plans and operations of Minovia as a result of the announcement and consummation of the Business Combination; (x) the ability to recognize the anticipated benefits of the Business Combination, which may be affected by, among other things, competition, the ability of Minovia to grow and manage growth profitably, maintain key relationships and retain its management and key employees; (xi) costs related to the Business Combination; (xii) changes in applicable laws, regulations, political and economic developments; (xiii) the possibility that Minovia may be adversely affected by other economic, business and/or competitive factors; (xiv) Minovia’s estimates of expenses and profitability; (xv) the failure to realize estimated shareholder redemptions, purchase price and other adjustments; and (xvi) other risks and uncertainties set forth in the filings by Launch One and Minovia with the SEC. There may be additional risks that neither Launch One nor Minovia presently know or that Launch One and Minovia currently believe are immaterial that could also cause actual results to differ from those contained in the forward–looking statements. Any forward–looking statements made by or on behalf of Launch One or Minovia speak only as of the date they are made. Neither Launch One nor Minovia undertakes any obligation to update any forward–looking statements to reflect any changes in their respective expectations with regard thereto or any changes in events, conditions or circumstances on which any such statements are based.

Contact

Minovia Therapeutics Ltd.
Natalie Yivgi Ohana, Co–Founder and CEO
+972–74–7039954
[email protected]

Launch One Acquisition Corp.
Jurgen van de Vyver
[email protected]
+1–510–692–9600

Investor Relations
Dave Gentry, CEO
RedChip Companies
+1–407–644–4256
[email protected]

Investor Relations
Jules Abraham
Managing Director, Communications
CORE IR
1–212–655–0924
[email protected]


GLOBENEWSWIRE (Distribution ID 9544499)

Nilo Therapeutics startet mit einer Serie-A-Finanzierung in Höhe von 101 Mio. USD zur Entwicklung einer neuen Medikamentenklasse, die auf neuronale Schaltkreise bei Immunerkrankungen abzielt, und ernennt Kim Seth zum Chief Executive Officer

NEW YORK, Oct. 09, 2025 (GLOBE NEWSWIRE) — Nilo Therapeutics, ein Biotechnologieunternehmen, das neuronale Schaltkreise nutzt, um die Immunhomöostase bei Krankheiten wiederherzustellen, startete heute mit einer Serie–A–Finanzierung in Höhe von 101 Mio. USD unter der Leitung von The Column Group (TCG), DCVC Bio und Lux Capital, unter Beteiligung der Gates Foundation und Alexandria Venture Investments. Zeitgleich mit der Markteinführung hat Nilo die Ernennung von Dr. Kim Seth zum Chief Executive Officer und Vorstandsmitglied bekanntgegeben.

Nilo wurde von den weltweit führenden Wissenschaftlern Dr. Charles Zuker (Columbia University), Dr. Ruslan Medzhitov (Yale University) und Dr. Steve Liberles (Harvard University) gegründet und entstand in Zusammenarbeit mit TCG, um bahnbrechende wissenschaftliche Erkenntnisse in der Neuroimmunologie in neue therapeutische Strategien umzusetzen. Dr. Seth wird gemeinsam mit Chief Scientific Officer Dr. Laurens Kruidenier die Umwandlung des Unternehmens von einem Stealth–Unternehmen in die nächste Wachstumsphase leiten. Die Finanzierung dient der Einrichtung von Nilos Labors in New York City, dem Ausbau seines interdisziplinären Forschungs– und Entwicklungsteams und der Weiterentwicklung der präklinischen Programme des Unternehmens.

Nilo entwickelt Medikamente, die neuronale Schaltkreise nutzen, um die Immunhomöostase zentral wiederherzustellen. Damit bietet das Unternehmen einen differenzierten Ansatz zur Immunmodulation, der über die herkömmliche Immunsuppression hinausgeht. Das Unternehmen baut auf bahnbrechenden wissenschaftlichen Entdeckungen aus dem Labor von Dr. Charles Zuker (Hauptforscher an der Columbia University und Forscher am Howard Hughes Medical Institute) auf, der bestimmte vagale Neuronen identifiziert hat, die die systemische Immunaktivierung und Entzündung regulieren. Durch die gezielte Beeinflussung dieser zentralen „Master–Regulator“–Kreisläufe zwischen Gehirn und Körper nutzt Nilo seinen neuartigen therapeutischen Ansatz, um mehrere Immunwege gleichzeitig zu modulieren, wodurch das Risiko einer Therapieresistenz verringert und die potenzielle Wirkung auf ein breites Spektrum von Autoimmun– und Entzündungskrankheiten mit großem ungedecktem Bedarf erweitert wird.

Dr. Seth verfügt über mehr als 25 Jahre Erfahrung in der Biopharmaindustrie und war in verschiedenen Führungspositionen bei mehreren Start–ups und börsennotierten Biotech–Unternehmen sowie großen Pharmaunternehmen tätig. Er hat zudem umfassende Fachkenntnisse in den Bereichen Unternehmensaufbau, Strategie und F&E–Aktivitäten, Geschäftsentwicklung, Finanzen und Kapitalmärkte. Vor seiner Tätigkeit bei Nilo war Dr. Seth als Chief Business Officer bei Repare Therapeutics tätig, einem Unternehmen im Bereich der Präzisionsonkologie. Dort war er Mitglied der Geschäftsleitung und maßgeblich daran beteiligt, das Unternehmen von der Pre–Series–A–Finanzierungsrunde über die Series–B–Finanzierungsrunde bis hin zum Börsengang zu skalieren. Er war für den Aufbau des US–Geschäfts des Unternehmens verantwortlich und leitete die Geschäftsentwicklung, um über eine Reihe globaler Plattform–, Vermögens– und klinischer Partnerschaften Finanzierungen in Höhe von über 250 Mio. USD zu generieren, was einem potenziellen Gesamtwert von über 4 Mrd. USD entspricht. Vor seiner Tätigkeit bei Repare hatte Dr. Seth Führungspositionen in den Bereichen Geschäftsentwicklung, Strategie und Betrieb bei einer Reihe von Biopharmaunternehmen, darunter Pfizer, inne und war Research Analyst für Large–Cap–Pharmaunternehmen/Spezialpharmaunternehmen bei Goldman Sachs. Er erwarb seinen BA cum laude in Wirtschaftswissenschaften am Harvard College und seinen Ph.D. in Neurobiologie in der Abteilung für Medizinische Wissenschaften an der Harvard University.

Dr. Seth schließt sich Dr. Laurens Kruidenier, Chief Scientific Officer, einem erfahrenen Experten für Immunologie und Arzneimittelforschung, an. Dr. Kruidenier war zuvor als CSO bei Cellarity und Prometheus Biosciences (von Merck übernommen) tätig, wo er mehrere innovative Therapien für Autoimmun– und Entzündungskrankheiten vom Konzept bis zur klinischen Anwendung vorantrieb. Zu Beginn seiner Karriere bei Takeda Pharmaceuticals und GSK leitete er Teams für präklinische Forschung und Entdeckungsforschung sowie die Strategie für Geschäftsentwicklung. Er promovierte in Immunologie an der Universität Leiden und seine Forschungsergebnisse wurden in führenden wissenschaftlichen Fachzeitschriften, darunter Nature, veröffentlicht.

„Nilo befindet sich in einer Phase des Wandels“, so Dr. Laurens Kruidenier, Chief Scientific Officer von Nilo Therapeutics. „Die Führungsqualitäten und Erfahrung von Dr. Seth werden unsere Mission beschleunigen, bahnbrechende Erkenntnisse aus der Neuroimmunologie in Medikamente umzusetzen, von denen Patienten mit einer Vielzahl von immunbedingten Erkrankungen profitieren könnten.“

„Wir freuen uns sehr, Dr. Seth als CEO begrüßen zu dürfen“, so Dr. Tim Kutzkey, Managing Partner bei The Column Group. „Mit seiner Erfolgsbilanz bei der Begleitung von Unternehmen von ihren Anfängen bis zum Börsengang und der erfolgreichen Umsetzung von Programmen bringt Dr. Seth sowohl Weitblick als auch Visionen mit. Seine Leidenschaft, bahnbrechende wissenschaftliche Erkenntnisse in innovative Medikamente umzusetzen, macht ihn zum idealen Partner, um Laurens' wissenschaftliche Führungsrolle zu ergänzen und Nilo in die nächste Wachstumsphase zu führen.“

„Es ist mir eine Ehre, Teil des unglaublich talentierten und engagierten Teams von Nilo zu werden“, so Kim Seth, Chief Executive Officer von Nilo Therapeutics. „Gemeinsam mit Laurens, unseren wissenschaftlichen Gründern von Weltklasse, und unseren Investoren bauen wir ein Unternehmen auf, das eine neue Generation von Therapien entwickeln wird, die die Gehirn–Immun–Achse nutzen, um die Behandlung von Autoimmun– und Entzündungserkrankungen zu revolutionieren.“

Über Nilo Therapeutics

Nilo Therapeutics ist ein Biotechnologieunternehmen, das eine neue Klasse von Medikamenten entwickelt, die neuronale Schaltkreise nutzen, um die Immunhomöostase bei Krankheiten wiederherzustellen. Durch die gezielte Beeinflussung der Master–Regulator–Schaltkreise zwischen Gehirn und Körper, die systemische Entzündungen zentral steuern, leistet Nilo Pionierarbeit bei einem differenzierten Ansatz zur Immunmodulation, der das Potenzial hat, ein breites Spektrum von Autoimmun– und Entzündungskrankheiten mit großem ungedecktem Bedarf zu behandeln. Das Unternehmen hat seinen Hauptsitz in New York, NY. www.nilotx.com

Weitere Informationen erhalten Sie unter [email protected].


GLOBENEWSWIRE (Distribution ID 9542701)

Lancement de Nilo Therapeutics avec un financement de série A de 101 millions de dollars en vue de développer une nouvelle classe de médicaments ciblant les circuits neuronaux dans les maladies immunitaires, et nomination de Kim Seth au poste de directeur général

 NEW YORK, 09 oct. 2025 (GLOBE NEWSWIRE) — Nilo Therapeutics, une société de biotechnologie qui mise sur les circuits neuronaux pour rétablir l’homéostasie immunitaire chez les patients malades, a été lancée aujourd’hui avec un financement de série A de 101 millions de dollars mené par The Column Group (TCG), DCVC Bio et Lux Capital, avec la participation de la Fondation Gates et d’Alexandria Venture Investments. Parallèlement à son lancement, Nilo a annoncé la nomination de Kim Seth, Ph.D., au poste de directeur général et membre du conseil d’administration.

Fondée par des scientifiques de renommée mondiale, Charles Zuker, Ph.D. (Université Columbia), Ruslan Medzhitov, Ph.D. (Université Yale) et Steve Liberles, Ph.D. (Université Harvard), Nilo a été créée en collaboration avec TCG afin de traduire des découvertes scientifiques révolutionnaires en neuro–immunologie en nouvelles stratégies thérapeutiques. Le Dr Seth rejoint le directeur scientifique Laurens Kruidenier, Ph.D., pour mener la transition de l’entreprise vers sa prochaine phase de croissance. Le financement permet la création des laboratoires de Nilo à New York, la croissance de son équipe de recherche et développement interdisciplinaire et l’avancement des programmes précliniques de l’entreprise.

Nilo développe des médicaments exploitant les circuits neuronaux dans le but de rétablir l’homéostasie immunitaire au niveau central, offrant ainsi une approche différenciée de l’immunomodulation allant bien au–delà de l’immunosuppression conventionnelle. La société s’appuie sur les découvertes scientifiques fondamentales du laboratoire de Charles Zuker, Ph.D. (responsable de recherche à l’université Columbia et chercheur à l’Institut médical Howard Hughes), qui a identifié des neurones spécifiques du nerf vague régulant l’activation immunitaire systémique et l’inflammation. En ciblant ces circuits cerveau–corps « régulateurs principaux », Nilo utilise son approche thérapeutique novatrice pour moduler plusieurs voies immunitaires de manière concertée, réduisant ainsi le risque de résistance thérapeutique et élargissant l’impact potentiel sur un large éventail de maladies auto–immunes et inflammatoires. Cette approche répond à un besoin important non satisfait.

Le Dr Seth apporte plus de 25 ans d’expérience dans l’industrie biopharmaceutique, ayant occupé des postes opérationnels dans plusieurs sociétés biotechnologiques en phase de démarrage et cotées en bourse, ainsi que dans de grandes sociétés pharmaceutiques. Il possède une vaste expertise dans la création d’entreprises, la stratégie et les opérations de R&D, le développement commercial, la finance et les marchés de capitaux. Avant de rejoindre Nilo, le Dr Seth a occupé le poste de directeur commercial chez Repare Therapeutics, une société spécialisée dans l’oncologie de précision, où, en tant que membre de l’équipe de direction, il a joué un rôle déterminant dans le développement de la société, depuis le financement de série A jusqu’au financement de série B et à l’introduction en bourse. Il était chargé de mettre en place les activités commerciales de l’entreprise aux États–Unis dont il a dirigé le développement commercial afin de générer plus de 250 millions de dollars de financement grâce à une série de partenariats mondiaux en matière de plateformes, d’actifs et de cliniques, représentant une valeur potentielle totale de plus de 4 milliards de dollars. Avant de rejoindre Repare, le Dr Seth a occupé des postes de direction dans les domaines du développement commercial, de la stratégie et des opérations au sein de plusieurs entreprises biopharmaceutiques, dont Pfizer, et a été analyste de recherche dans le domaine des produits pharmaceutiques à grande capitalisation et des produits pharmaceutiques spécialisés chez Goldman Sachs. Il a obtenu une licence en économie avec mention très bien au Harvard College et un doctorat en neurobiologie à la Division des sciences médicales de l’université de Harvard.

Le Dr Seth rejoint Laurens Kruidenier, Ph.D., directeur scientifique, un leader accompli dans le domaine de l’immunologie et de la découverte de médicaments. Le Dr Kruidenier a précédemment occupé le poste de directeur scientifique chez Cellarity et Prometheus Biosciences (racheté par Merck), où il a fait progresser plusieurs thérapies innovantes, du concept à la clinique, dans le domaine des maladies auto–immunes et inflammatoires. Au début de sa carrière chez Takeda Pharmaceuticals et GSK, il a dirigé des équipes de recherche préclinique et de découverte, ainsi que la stratégie de développement commercial. Il a obtenu son doctorat en immunologie à l’université de Leyde et ses recherches ont été publiées dans des revues scientifiques de premier plan, notamment Nature.

« Nilo se trouve à un moment charnière », a déclaré Laurens Kruidenier, Ph.D., directeur scientifique de Nilo Therapeutics. « Le leadership et l’expérience de Kim permettront d’accélérer notre mission consistant à traduire les avancées révolutionnaires en neuro–immunologie en médicaments pouvant bénéficier aux patients atteints d’un large éventail de maladies immunitaires. »

« Nous sommes ravis d’accueillir Kim au poste de PDG », a déclaré le Dr Tim Kutzkey, associé directeur chez The Column Group. « Fort d’une expérience éprouvée dans l’accompagnement d’entreprises depuis leurs débuts jusqu’à leur introduction en bourse et dans la mise en œuvre réussie de programmes, Kim apporte à la fois une grande expérience et une vision. Sa passion pour la transformation de la science audacieuse en médicaments révolutionnaires fait de lui le partenaire idéal pour compléter le leadership scientifique de Laurens et mener Nilo vers sa prochaine phase de croissance. »

« C’est un honneur de rejoindre l’équipe incroyablement talentueuse et engagée de Nilo », a déclaré Kim Seth, PDG de Nilo Therapeutics. « Avec Laurens, nos fondateurs scientifiques de renommée mondiale et nos investisseurs, nous bâtissons une entreprise bien placée pour fournir une nouvelle génération de traitement exploitant l’axe cerveau–immunité afin de transformer le traitement des maladies auto–immunes et inflammatoires. »

À propos de Nilo Therapeutics

Nilo Therapeutics est une société de biotechnologie qui développe une nouvelle classe de médicaments exploitant les circuits neuronaux dans le but de rétablir l’homéostasie immunitaire chez les patients malades. En ciblant les principaux circuits cerveau–corps responsables de la régulation centrale de l’inflammation systémique, Nilo est à l’avant–garde d’une approche différenciée de l’immunomodulation qui pourrait permettre de traiter un large éventail de maladies auto–immunes et inflammatoires. Une approche qui répond à un besoin important non satisfait. La société a son siège à New York, NY. www.nilotx.com

Pour plus d’informations, veuillez contacter [email protected].


GLOBENEWSWIRE (Distribution ID 9542701)

Nilo Therapeutics é lançada com financiamento de US $101 milhões da Série A para promover uma nova classe de medicamentos direcionados a circuitos neurais em doenças imunológicas e nomeia Kim Seth como CEO

NOVA YORK, Oct. 08, 2025 (GLOBE NEWSWIRE) — A Nilo Therapeutics, uma empresa de biotecnologia que utiliza circuitos neurais para restaurar a homeostase imunológica em doenças, foi lançada hoje com um financiamento de US $101 milhões da Série A liderado por The Column Group (TCG), DCVC Bio e Lux Capital, com participação da Gates Foundation e da Alexandria Venture Investments. No seu lançamento, a Nilo Therapeutics anunciou a nomeação de Kim Seth, Ph.D. como Diretor Executivo e Diretor do Conselho.

Fundada pelos cientistas líderes mundiais Charles Zuker, Ph.D. (Columbia University), Ruslan Medzhitov, Ph.D. (Yale University) e Steve Liberles, Ph.D. (Harvard University), a Nilo foi criada em colaboração com a TCG para transformar conhecimentos científicos inovadores em neuroimunologia em novas estratégias terapêuticas. O Dr. Seth junta–se ao Diretor Científico Laurens Kruidenier, Ph.D., na liderança da transição da empresa da invisibilidade para a sua próxima fase de crescimento. O financiamento estimula o estabelecimento dos laboratórios da Nilo em Nova York, o crescimento da sua equipe interdisciplinar de pesquisa, e o desenvolvimento e o avanço dos programas pré–clínicos da empresa.

A Nilo está desenvolvendo medicamentos que utilizam os circuitos neurais para restaurar centralmente a homeostase imunológica, oferecendo uma abordagem diferenciada à imunomodulação e indo além da imunossupressão convencional. A empresa baseia–se nas descobertas científicas seminais do laboratório de Charles Zuker, Ph.D. (Pesquisador Principal da Columbia University e Pesquisador do Howard Hughes Medical Institute), que identificou neurônios vagais específicos que regulam a ativação imune sistêmica e a inflamação. Ao direcionar esses circuitos centrais do corpo cerebral “regulador mestre”, a Nilo está empregando sua nova abordagem terapêutica para modular múltiplas vias imunológicas em conjunto, reduzindo o risco de resistência terapêutica e ampliando o impacto potencial em um amplo espectro de doenças autoimunes e inflamatórias com grandes necessidades não atendidas.

O Dr. Seth tem mais de 25 anos de experiência no setor biofarmacêutico, tendo ocupado cargos operacionais em várias empresas de biotecnologia em estágio inicial e públicas, e grandes empresas farmacêuticas. Ele tem ampla experiência no estabelecimento de empresas, estratégia e operações de P&D, desenvolvimento de negócios, finanças e mercados de capitais. Antes da Nilo, o Dr. Seth atuou como Diretor de Negócios da Repare Therapeutics, uma empresa de oncologia de precisão, onde foi membro da Equipe de Liderança Executiva e foi fundamental para a expansão da empresa desde a pré–Série A até o financiamento e IPO da Série B. Ele foi responsável por estabelecer as operações comerciais da empresa nos EUA e liderou o desenvolvimento de negócios para gerar mais de US $250 milhões em financiamento por meio de várias plataformas globais, ativos e parcerias clínicas, representando mais de US $4 bilhões em valor potencial total. Antes da Repare, o Dr. Seth ocupou cargos de liderança em BD, estratégia e operações em várias empresas biofarmacêuticas, incluindo a Pfizer, e foi analista de pesquisa de Large–cap Pharmaceuticals/Specialty Pharmaceuticals da Goldman Sachs. Ele obteve seu BA cum laude em Economia no Harvard College e seu Ph.D. em Neurobiologia na Divisão de Ciências Médicas da Harvard University.

O Dr. Seth se junta a Laurens Kruidenier, Ph.D., Diretor Científico, um renomado líder em imunologia e descoberta de medicamentos. O Dr. Kruidenier atuou anteriormente como CSO na Cellarity e na Prometheus Biosciences (adquirida pela Merck), onde avançou várias terapias inovadoras do conceito à clínica em doenças autoimunes e inflamatórias. No início da sua carreira na Takeda Pharmaceuticals e na GSK, ele liderou equipes de pesquisa pré–clínica e de descoberta, bem como a estratégia de desenvolvimento de negócios. Ele obteve seu doutorado em imunologia pela Leiden University e sua pesquisa foi publicada nas principais revistas científicas, incluindo a Nature.

“A Nilo está em um momento de transformação”, disse Laurens Kruidenier, Ph.D., Diretor Científico da Nilo Therapeutics. “A liderança e a experiência de Kim acelerarão nossa missão de transformar a neuroimunologia inovadora em medicamentos que possam beneficiar os pacientes em uma ampla gama de doenças imunológicas.”

“Estamos contentes em receber Kim como CEO”, disse o Dr. Tim Kutzkey, sócio–gerente do The Column Group. “Com um histórico de orientação de empresas desde seus estágios iniciais até o IPO e programas de avanço bem–sucedidos, Kim tem amplitude e visão. Sua paixão por transformar a ciência ousada em medicamentos inovadores faz dele o parceiro ideal para complementar a liderança científica de Laurens e levar a Nilo à sua próxima fase de crescimento.”

“É uma honra me juntar à equipe incrivelmente talentosa e dedicada da Nilo”, disse Kim Seth, Diretor Executivo da Nilo Therapeutics. “Juntamente com Laurens, nossos fundadores científicos de classe mundial e nossos investidores, estamos criando uma empresa posicionada para oferecer uma nova geração de terapias que utilizam o eixo imune cerebral para transformar o tratamento de doenças autoimunes e inflamatórias.”

Sobre a Nilo Therapeutics

A Nilo Therapeutics é uma empresa de biotecnologia que desenvolve uma nova classe de medicamentos que utiliza os circuitos neurais para restaurar a homeostase imune na doença. Ao direcionar circuitos cérebro–corpo reguladores mestres que controlam centralmente a inflamação sistêmica, a Nilo é pioneira com uma abordagem diferenciada para imunomodulação com potencial para tratar um amplo espectro de doenças autoimunes e inflamatórias com grandes necessidades não atendidas. A empresa está localizada em New York, NY. www.nilotx.com

Para mais informações, contacte: [email protected].


GLOBENEWSWIRE (Distribution ID 9542701)

Nilo Therapeutics launches with $101 million Series A financing to advance a new class of medicines targeting neural circuits in immune disease and appoints Kim Seth as Chief Executive Officer

NEW YORK, Oct. 08, 2025 (GLOBE NEWSWIRE) — Nilo Therapeutics, a biotechnology company harnessing neural circuits to restore immune homeostasis in disease, launched today with a $101 million Series A financing led by The Column Group (TCG), DCVC Bio, and Lux Capital, with participation from the Gates Foundation and Alexandria Venture Investments. Coinciding with its launch, Nilo announced the appointment of Kim Seth, Ph.D., as Chief Executive Officer and Board director.

Founded by world–leading scientists Charles Zuker, Ph.D. (Columbia University), Ruslan Medzhitov, Ph.D. (Yale University), and Steve Liberles, Ph.D. (Harvard University), Nilo was created in collaboration with TCG to translate groundbreaking scientific insights in neuro–immunology into new therapeutic strategies. Dr. Seth joins Chief Scientific Officer Laurens Kruidenier, Ph.D., in leading the company’s transition from stealth into its next stage of growth. The financing fuels the establishment of Nilo’s laboratories in New York City, growth of its interdisciplinary research and development team, and advancement of the company’s preclinical programs.

Nilo is developing drugs that harness neural circuits to restore immune homeostasis centrally, offering a differentiated approach to immunomodulation and moving beyond conventional immunosuppression. The company builds on seminal scientific discoveries from the laboratory of Charles Zuker, Ph.D. (Columbia University Principal Investigator and Howard Hughes Medical Institute Investigator), which identified specific vagal neurons that regulate systemic immune activation and inflammation. By targeting these central “master regulator” brain–body circuits, Nilo is employing its novel therapeutic approach to modulate multiple immune pathways in concert, reducing the risk of therapeutic resistance and broadening potential impact across a wide spectrum of autoimmune and inflammatory diseases with large unmet need.

Dr. Seth brings over 25 years of biopharma industry experience, with operating roles across multiple early–stage and public biotech companies and large pharma. He has broad expertise in company building, strategy and R&D operations, business development, finance and capital markets. Prior to Nilo, Dr. Seth served as Chief Business Officer at Repare Therapeutics, a precision oncology company, where he was a member of the Executive Leadership Team and was instrumental in scaling the company from pre–Series A through its Series B financing and IPO. He was responsible for establishing the company’s US business operations and led business development to generate over $250 million in financing through a range of global platform, asset, and clinical partnerships, representing over $4 billion in total potential value. Prior to Repare, Dr. Seth held leadership positions in BD, strategy, and operations across a number of biopharma companies including Pfizer, and was a Large–cap Pharmaceuticals /Specialty Pharmaceuticals research analyst at Goldman Sachs. He earned his BA cum laude in Economics at Harvard College, and his Ph.D. in Neurobiology in the Division of Medical Sciences at Harvard University.

Dr. Seth joins Laurens Kruidenier, Ph.D., Chief Scientific Officer, an accomplished immunology and drug discovery leader. Dr. Kruidenier previously served as CSO at Cellarity and at Prometheus Biosciences (acquired by Merck), where he advanced multiple innovative therapies from concept to clinic in autoimmune and inflammatory diseases. Earlier in his career at Takeda Pharmaceuticals and GSK, he led preclinical and discovery research teams as well as business development strategy. He earned his Ph.D. in immunology from Leiden University, and his research has been published in leading scientific journals, including Nature.

“Nilo is at a transformative moment,” said Laurens Kruidenier, Ph.D., Chief Scientific Officer of Nilo Therapeutics. “Kim’s leadership and experience will accelerate our mission to translate breakthrough neuro–immunology into medicines that could benefit patients across a broad range of immune–driven diseases.”

“We are thrilled to welcome Kim as CEO,” said Dr. Tim Kutzkey, Managing Partner at The Column Group. “With a track record of guiding companies from their earliest stages through IPO, and successfully advancing programs, Kim brings both breadth and vision. His passion for translating bold science into breakthrough medicines makes him the ideal partner to complement Laurens’ scientific leadership and lead Nilo into its next phase of growth.”

“It’s an honor to join the incredibly talented and committed team at Nilo,” said Kim Seth, Chief Executive Officer of Nilo Therapeutics. “Together with Laurens, our world–class scientific founders, and our investors, we are building a company positioned to deliver a new generation of therapies that harness the brain–immune axis to transform the treatment of autoimmune and inflammatory conditions.”

About Nilo Therapeutics

Nilo Therapeutics is a biotechnology company developing a new class of medicines that harness neural circuits to restore immune homeostasis in disease. By targeting master regulator brain–body circuits that centrally control systemic inflammation, Nilo is pioneering a differentiated approach to immunomodulation with the potential to treat a wide spectrum of autoimmune and inflammatory diseases with large unmet need. The company is headquartered in New York, NY. www.nilotx.com

For more information, contact [email protected]


GLOBENEWSWIRE (Distribution ID 9542136)

Angelini Pharma Signs Exclusive Option Agreement With Sovargen To License Global Development and Commercialization Rights For Innovative Brain Health Asset

  • Angelini Pharma secures exclusive option to license global development and commercialization rights for SVG1051, a pre–clinical investigational novel compound with broad potential to treat brain health diseases, excluding the Republic of Korea, China, Hong Kong, Macau and Taiwan
  • Sovargen receives upfront payment and is eligible for future milestone–dependent payments and royalties
  • Agreement further expands Angelini Pharma’s strong portfolio and deep therapeutic expertise in brain health, following a series of strategic partnerships in the space, including in orphan and rare epilepsy

ROME, Sept. 22, 2025 (GLOBE NEWSWIRE) — Angelini Pharma, part of the privately owned Angelini Industries, and Sovargen, a South–Korean biotechnology company, announced today that they signed an exclusive global option agreement for the development and commercialization of Sovargen’s innovative brain health asset SVG105.

Under the terms of the agreement, Angelini Pharma and Sovargen will collaboratively lead the pre–clinical development efforts for SVG105 and, following an initial option period, Angelini Pharma will have the right to advance the compound into clinical development and commercialization outside of the Republic of Korea, China, Hong Kong, Macau and Taiwan. SVG105 is a potentially first–in–class anti–sense oligonucleotide technology to target mTOR (mammalian target of rapamycin) pathways. mTOR is a genetically validated target for a number of brain health disorders, including drug–resistant childhood epilepsy.i

Sovargen will receive an upfront payment and will also be eligible to receive additional payments upon pre–defined development and commercial milestones of up to approx. US$550 million, as well as tiered royalties on post–approval net sales.

The announcement follows a number of strategic acquisitions and collaboration agreements that Angelini Pharma has entered over the course of the past two years, which have bolstered the company’s pipeline in brain health, adding to its strong portfolio in the space through sustained investment. In May 2025, Angelini Pharma and GRIN Therapeutics Inc. announced a collaboration for the development and commercialization rights outside of North America for radiprodil, an investigational drug currently being studied in multiple rare genetic epilepsies and neurodevelopmental disorders. A few days earlier, the company signed an asset purchase and assignment agreement for the development and commercialization of OmniAb’s innovative preclinical asset RO’599, a novel preclinical–stage investigational compound with broad potential to treat various brain health diseases. Last year, Angelini Pharma entered into a strategic partnership with Cureverse, a Korean spin–off of the Korean Institute of Science and Technology, which is developing small molecules with broad CNS applications. In 2023, the company partnered with JCR Pharmaceuticals, a Japanese biotech company with a breakthrough blood–brain barrier technology based on a transferrin receptor mechanism, allowing biologics to cross the barrier. Consequently, Angelini’s brain health pipeline now includes diversified and modern therapeutic modalities ranging from innovative small molecule compounds to biologics and anti–sense oligonucleotides.

“This partnership with Sovargen further solidifies Angelini Pharma’s leading role in the field of brain health, adding additional breadth to our robust portfolio and pipeline,” said Jacopo Andreose, Chief Executive Officer of Angelini Pharma. “Neurological disorders like epilepsy are major contributors to global disease challenges.ii For example, many people living with epilepsy are still unable to reach seizure control despite combination treatment of several anti–seizure medications.iii Our work on SVG105 will be motivated by the ambition to bring much–needed solutions to people living with brain health conditions across the world.”

“We are incredibly excited about the opportunity to work with Angelini Pharma to further advance SVG105,” said Cheolwon Park, Chief Executive Officer at Sovargen. “Our research so far demonstrates great potential for SVG105 to transform the treatment landscape in brain health and we are confident that Angelini Pharma’s strong therapeutic expertise will propel our research further and bring us closer to identifying new treatment options for patients in need.”

Brain Health
Brain health as a therapeutic area includes both neurological and mental health conditions.iv Brain health is defined by the World Health Organization as a state of brain functioning across cognitive, sensory, social–emotional, behavioral and motor domains, allowing a person to realize their full potential over the course of their life, irrespective of the presence or absence of disorders.v

Brain health represents an urgent global health priority. An estimated 179 million Europeans are living with brain health conditionsvi and more than 18% of all health loss around the world is associated with brain conditions.vii Additionally, brain health conditions are responsible for considerable individual, economic and societal impact, including loss of independence, reduced productivity, strained relationships, increased risk of suicide as well as high healthcare costs.viii There is an urgent need to raise awareness, and reduce stigma, prejudice and discrimination, to ensure that brain health is valued, promoted and protected for all.v

Epilepsy

Epilepsy is one of the most widespread neurological diseases in the world, affecting globally approximately 50 million people of all ages.ix In Europe, up to six million people are estimated to be living with this disease.x Epilepsy can have multiple potential causes, including structural, metabolic, genetic and other factors, though approximately half of cases worldwide do not have a known cause.ix

The complications associated with epilepsy are severe, with a risk of premature mortality up to three times higher than the general population.ix The recurrent seizures associated with this condition also have wide–ranging effects on a person’s broader physical and mental health, education and employment opportunities and other quality of life factors.ix

Treatments are available to help reduce seizures and improve quality of life, however approximately 40% of people living with epilepsy are still uncontrolled despite the treatment with two anti–seizure medications.iii

Angelini Pharma
Angelini Pharma is an international pharmaceutical company, part of the privately owned multi–business Angelini Industries. The Company researches, develops and commercializes health solutions with a focus on the areas of Brain Health, including Mental Health and Epilepsy, and Consumer Health. Founded in Italy at the beginning of the 20th century, Angelini Pharma operates directly in 20 countries, employing more than 3,000 people. Its products are marketed in over 70 countries through strategic alliances with leading international pharmaceutical groups. More information: https://www.angelinipharma.com.

Angelini Industries
Angelini Industries is a multinational industrial group founded in Ancona in 1919 by Francesco Angelini. Today, Angelini Industries represents a solid and diversified industrial reality that employs approximately 5,800 employees and operates in 21 countries around the world with revenues of over 2 billion euros, generated in the health, industrial technology, and consumer goods sectors. A targeted investment strategy for growth; constant commitment to research and development; deep knowledge of markets and business sectors, make Angelini Industries one of the Italian companies of excellence in the sectors in which it operates. More information: www.angeliniindustries.com.

Sovargen
Founded in 2018, Sovargen is a Korean biotech company pioneering treatments for intractable brain diseases caused by somatic mutations—genetic changes acquired during brain development or aging. These mutations underlie serious conditions like focal cortical dysplasia (FCD) type II, hemimegalencephaly, and brain tumors, yet remain largely unaddressed.

Sovargen’s proprietary antisense oligonucleotide (ASO) platform enables precise gene modulation in the brain. Its lead program, SVG105, is a first–in–disease ASO therapy in preclinical development for drug–resistant epilepsy caused by FCD type II. With a growing pipeline and a differentiated scientific approach, Sovargen is advancing next–generation CNS therapies to bring new hope to patients worldwide. More information: www.sovargen.com.

Contact                
Chiara Antoniucci
Global Head of Brand and Media Communications, Angelini Pharma
+39 3477133926
[email protected]

Rosie JH Lee
Director of Corporate PR, Sovargen
+82–70–5222–2771
[email protected]

1 SVG105 is an investigational compound, not approved for use by regulatory authorities.

i Data on file (Sovargen).
ii Institute for Health Metrics and Evaluation (IHME). Global burden of conditions affecting the nervous system. Available at: https://www.healthdata.org/research–analysis/library/global–burden–conditions–affecting–nervous–system Last accessed: July 2025.
iii Chen Z, Brodie MJ, Liew D, Kwan P. Treatment Outcomes in Patients With Newly Diagnosed Epilepsy Treated With Established and New Antiepileptic Drugs: A 30–Year Longitudinal Cohort Study. JAMA Neurol. 2018 Mar 1;75(3):279–286.
iv Winkler AS, et al. Lancet Glob Health. 2024;12(5):e735–e736.
v WHO. Optimizing brain health across the life course: WHO position paper. Geneva: World Health Organization; 2022.
vi Nutt D, et al. Eurohealth (Int) 2017;23:21–5.
vii IHME. Understanding brain health around the world. Available at: https://brainhealthatlas.org/ Last accessed: July 2025.
viii WHO. World mental health report: transforming mental health for all. Geneva: World Health Organization; 2022.
ix WHO. “Epilepsy Key Facts.” N.p., 9 Feb. 2023. Web. 24 Aug. 2023.
x Behr et al. Epidemiology of epilepsy. Revue Neurologique 2016 Jan; 172(1):27–36. doi: 10.1016/j.neurol.2015.11.003.


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