Zenas BioPharma Announces Publication of Phase 2 Study of Obexelimab, an Investigational Treatment for IgG4-Related Disease (IgG4-RD), in The Lancet Rheumatology

Study found obexelimab produced rapid, strong, and sustained clinical improvement, including complete clinical remission, in most patients with active IgG4–RD

Results support the continued development of obexelimab for the treatment of IgG4–RD and potentially other B cell–mediated autoimmune conditions

WALTHAM, Mass., Aug. 01, 2023 (GLOBE NEWSWIRE) — Zenas BioPharma, a global biopharmaceutical company committed to becoming a leader in the development and commercialization of immune–based therapies, announces The Lancet Rheumatology has published findings from a Phase 2 study evaluating obexelimab for the treatment of patients with IgG4–Related Disease (IgG4–RD). Based on the results of this study, a Phase 3 study in patients with IgG4–RD is ongoing to further investigate the efficacy and safety of obexelimab administered as a subcutaneous injection.

IgG4–RD is a chronic, immune–mediated fibro–inflammatory disease that can affect multiple organs including the major salivary glands, orbits, lacrimal glands, pancreas, biliary tree, lungs, kidneys, and retroperitoneum. Approximately 20,000 patients are diagnosed with IgG4–RD in the United States alone. Despite its increasing recognition, there remains a need for further research and effective therapeutic options for individuals living with this debilitating disease.

Across the world, the use of glucocorticoids is widely considered to be the standard of care for treating IgG4–RD. There are no approved treatment options for this condition. While commonly used, glucocorticoids and available B cell depleting therapies rarely lead to long–term, treatment–free remissions, and are associated with a high risk of toxicity in these patients. Such therapies also impair vaccine responses, including those for SARS–CoV–2 and influenza.

In a prospective, open–label, single arm, single–center pilot study to assess the efficacy and safety of obexelimab in the treatment of patients with IgG4–RD (clinicaltrials.gov registration NCT02725476), obexelimab demonstrated strong improvement in the IgG4–RD Responder Index, a measure of disease activity, by inhibiting B cell function, without depleting B cells.

The published manuscript, titled "Obexelimab for the Treatment of Patients with IgG4–Related Disease: An Open–Label, Single–Arm, Pilot Study to Evaluate Efficacy, Safety, and Mechanism of Action," is available online and will appear in the August issue of The Lancet Rheumatology 2023;5(8) [E428–E429].

The following are the key findings in the paper:

  • Obexelimab produced rapid, strong, and sustained clinical improvement, including complete remission (IgG4–RD Responder Index score of 0), in most patients with active IgG4–RD.
  • During obexelimab treatment, reductions in circulating B cells, including plasmablasts, were observed without evidence of cell death.
  • Additionally, reduction of circulating B cells and rapid return to near normal levels after treatment discontinuation suggests that obexelimab may lead to B cell sequestration in lymphoid organs or the bone marrow.
  • Obexelimab was well tolerated. The majority of treatment–related adverse events were grades 1 or 2, with the most common adverse events being gastrointestinal infusion–related events, most of which were mild.

"Our findings are a significant step forward in understanding the underlying mechanisms of IgG4–Related Disease; paving the way for more targeted treatment strategies," said John Stone, MD, MPH, Professor of Medicine at Harvard Medical School, and the Edward A. Fox Chair in Medicine at Mass General Hospital. "Our team is honored to have our research recognized by The Lancet Rheumatology, and we are immensely grateful to the patients who participated in this groundbreaking study."

About Obexelimab

Obexelimab is an investigational Phase 3–stage, bifunctional, non–cytolytic, humanized monoclonal antibody that mimics the action of antigen–antibody complexes by binding CD19 and FcRIIb to inhibit B–lineage cell activity. In several early–stage clinical studies in various autoimmune diseases, 198 subjects were treated with obexelimab. In these clinical studies, obexelimab demonstrated effective inhibition of B cell function without depleting the cells, resulting in encouraging treatment effect in patients with various autoimmune diseases. Zenas acquired exclusive worldwide rights to obexelimab from Xencor, Inc.

More information on the Phase 3 (INDIGO) study for the treatment of IgG4 Related Disease is available at clinicaltrials.gov: NCT05662241.

About Zenas BioPharma

Zenas BioPharma is a global biopharmaceutical company committed to becoming a leader in the development and commercialization of immune–based therapies for patients around the world. With clinical development and operations globally, Zenas is advancing a deep and balanced global portfolio of potential first– and best–in–class autoimmune therapeutics in areas of high unmet medical need while meeting the value requirements of the dynamic global healthcare environment. The company's pipeline continues to grow through our successful business development strategy. Our experienced leadership team and network of business partners drive operational excellence to deliver potentially transformative therapies to improve the lives of those facing autoimmune and rare diseases. For more information about Zenas BioPharma, please visit www.zenasbio.com and follow us on Twitter at @ZenasBioPharma and LinkedIn.

Investor and Media Contact:
Joe Farmer, President & COO
Zenas BioPharma
IR@zenasbio.com


GLOBENEWSWIRE (Distribution ID 8884766)

Ukraine Humanitarian Response Plan Only 30 Percent Funded

Humanitarian Coordinator for Ukraine, Denise Brown. Credit: UN

Humanitarian Coordinator for Ukraine, Denise Brown. Credit: UN

By Abigail Van Neely
UNITED NATIONS, Aug 1 2023 – Civilian infrastructure is under attack in cities across Ukraine, and the need for long-term aid grows. However, the United Nations’ 2023 Humanitarian Response Plan for Ukraine is only 30 percent funded, the Humanitarian Coordinator for Ukraine, Denise Brown, told journalists.

The response plan for the year calls for USD 3.9 billion to continue frontline deliveries several times a week, prepare Ukraine for winter, and support long-term recovery and rebuilding in the country. Brown said that funding meant to help at least 11 million Ukrainians has been inadequate due to unexpected demands.

Access to water for drinking and irrigation has become a key issue following the destruction of Ukraine’s Kakhovka Dam. Top-floor residents have watched their downstairs neighbors evacuate flooded apartments. Several thousand people have been displaced due to water damage. Brown said that while the situation has been managed in the short term, the UN team continues searching for long-term solutions to water contamination.

Brown highlighted that the need for trauma support is growing at a fast pace. While it is too early to assess the long-term psychological effects of the current war, a 2019 study found a high prevalence of PTSD and depression in Ukrainians displaced by the Russian invasion of Ukraine in 2014.

The Black Sea city of Odesa has been attacked by Russia several times in the past weeks. The city is an important hub for the UN and the humanitarian community because it acts as a staging area for frontline responses, Brown explained. She recently traveled there to check on UN staff.

In Odesa, Brown visited the historical Orthodox cathedral. The Transfiguration Cathedral is in the center of a protected part of the city and within 700 meters of where most UN staff live and work. Brown learned that neighboring civilians had taken shelter in a bunker in the cathedral when an air siren went off, not knowing it would be hit. There was damage throughout the building, with one wing completely destroyed. A team of UNESCO experts has been deployed to further assess the condition of the cathedral. Brown said she was heartened to see community members gather to clean up broken glass.

“What I saw in Odesa last week with my own eyes is being repeated across many big cities in Ukraine,” Brown said.

According to Brown, big cities with a UN presence nearby are regularly targeted. Whole neighborhood blocks have been struck, and entire buildings have come down. Attacks on infrastructure like critical ports have hurt civilian workers, Ukrainian farmers, and vulnerable people in the Global South who rely on grain from the region. Access to resources has been a particular concern since Russia’s termination of the Black Sea Grain Initiative.

The UN continues to advocate for access to Russian-occupied territories for the purpose of providing aid. Brown said they have been denied due to “security concerns.”

“The humanitarian situation hasn’t changed… the only thing that’s going to relieve that situation is if the war stops,” Brown said.

IPS UN Bureau Report

 


!function(d,s,id){var js,fjs=d.getElementsByTagName(s)[0],p=/^http:/.test(d.location)?’http’:’https’;if(!d.getElementById(id)){js=d.createElement(s);js.id=id;js.src=p+’://platform.twitter.com/widgets.js’;fjs.parentNode.insertBefore(js,fjs);}}(document, ‘script’, ‘twitter-wjs’);  

Afghan Girls, Women Deprived of Education, Find Hope in Africa

Shabana Basij-Rasikh, co-founder and President of SOLA, speaks at the Women Deliver conference in Rwanda. Credit: Aimable Twahirwa/ IPS

Shabana Basij-Rasikh, co-founder and President of SOLA, speaks at the Women Deliver conference in Rwanda. Credit: Aimable Twahirwa/IPS

By Aimable Twahirwa
KIGALI, Aug 1 2023 – When providing education to her small group of Afghan girls, who had been studying at a boarding school back home, became tenuous, Shabana Basij-Rasikh, relocated them to Rwanda.

She had set up a pioneering school under the project SOLA, the Afghan word for peace, and a short form for School of Leadership Afghanistan. But as the Taliban swept to power in August 2021, she closed the doors of the school, destroyed any school records which could help identify the girls, and on August 25, relocated 250 members of the SOLA community, including the student body and graduates from the programme, totally more than 100 girls, to Rwanda.

Basij-Rasikh, co-founder and SOLA’s President said a major challenge had been the lack of resources and capacity to teach Afghan girls after the return of the Taliban deprived right to education of girls in secondary schools and above.

As the Taliban swept back into power in Afghanistan in the summer of 2021, Shabana Basij-Rasikh, the founder of the nation’s only all-girls boarding school, initially ran the school out of a former principal’s living room. But that soon became untenable.

Speaking on the sidelines of The Women Deliver 2023 Conference (WD2023), which took place in Kigali from 17-20 July 2023, Basij-Rasikh, who completed her undergraduate studies in the United States, explained that when Kabul fell under the control of the Taliban, she managed within a short time to evacuate the entire school community to Rwanda.

“Although we managed to move the school to a safe country, it is still embarrassing and shameful for me since Afghanistan is the only country in the world where women and girls’ access to education has been suspended,” she said.

Initially, SOLA started as a scholarship program where Afghan youth would be identified and could access quality education abroad and, later on, go back to their home country as highly-skilled Afghans in whichever profession they chose.

“When the US announced that they were to withdraw their troops in Afghanistan, it created a lot of anxiety among young Afghans who were in the West hoping to return to the country.”

Basij-Rasikh regrets that some of her former students, who were able to leave Afghanistan after the Taliban’s return, are still struggling to continue their education overseas.

“We wish to see many Afghan girls return to schools,” she said, explaining that the migration status of the students in many countries restricted their access to education.

Since the school opened last year’s admissions season, Shabana Basij-Rasikh and her team have been inviting Afghan girls worldwide to apply and join the rest in Rwanda. Last year they enrolled 27 girls in their first intake.

“The major challenge is that there are several hundreds of thousands of girls who want to join our campus, but space is limited, and so places are being granted on merit and need,” Shabana told IPS.

Shabana argues investing in girls’ education is a smart investment; she is convinced that the current situation in Afghanistan must and should not be accepted or supported by any country around the world.

On September 18, 2021, a month after taking over the country, the Taliban ordered the reopening of only boys’ secondary schools. A few months later, in March 2022, according to human rights organizations, the Taliban again pledged to reopen all schools, but they officially closed girls’ secondary schools.

“These girls deserve the opportunity to realize their full potential, and the international community has an important role to play,” Shabana said.

UNESCO’s latest figures show that 2,5 million or 80 percent of school-aged Afghan girls and women are out of school.  The order suspending university education for women, announced in December last year, affects more than 100,000 students attending government and private institutions, according to the UN agency.

On the sidelines of the Women Deliver Conference 2023, Senegalese President Macky Sall pledged that his government would offer 100 scholarships for women who have seen their right to education decimated under Taliban rule in Afghanistan to pursue their university degrees in Senegal.

Rwanda is one of several African countries that agreed to temporarily host evacuated Afghans.

Sall, who was reacting to the concerns raised by Basij-Rasikhat, said his Government was ready to give chance to Afghan girls to pursue their studies.

So far, SOLA school has received 2,000 applications across 20 countries where some Afghans are living.

In 2022, it received 180 applications from Afghans living in 10 countries, but only 27 girls were admitted.

“That explains how families in Afghanistan are ready to support the girls in moving abroad to pursue their education,” Shabana said.

“Boarding schools that allow Afghan girls to study and live together are the best way to promote their education.”

IPS UN Bureau Report

 


!function(d,s,id){var js,fjs=d.getElementsByTagName(s)[0],p=/^http:/.test(d.location)?’http’:’https’;if(!d.getElementById(id)){js=d.createElement(s);js.id=id;js.src=p+’://platform.twitter.com/widgets.js’;fjs.parentNode.insertBefore(js,fjs);}}(document, ‘script’, ‘twitter-wjs’);  

Conagen and Sumitomo Chemical jointly develop a new era of renewable carbon materials

Bedford, Mass., Aug. 01, 2023 (GLOBE NEWSWIRE) — Conagen, the bioplatform innovator and biomanufacturer, and Sumitomo Chemical, Japan's leading chemical company, have announced to jointly develop p–hydroxystyrene (HS) and its polymer, poly p–hydroxystyrene (PHS), using a combination of biosynthesis, chemosynthesis, and polymerization. The monomer and the polymer are 100% renewable carbon, marking a new era of sustainable production.

Developing PHS using a combination of biosynthesis, chemosynthesis, and polymerization represents a significant breakthrough in sustainable material production. Efforts to reduce reliance on petroleum and transition towards renewable and sustainable alternatives have gained momentum in recent years. With renewable biomass as the starting material, this joint devolvement between Conagen and Sumitomo Chemical creates an environmentally friendly and cost–effective product. The partnership is in the lead position of active global initiatives to reduce petroleum–based products' consumption and environmental impact.

This partnership represents a significant milestone in developing sustainable materials, and this approach to PHS production is expected to reduce the carbon footprint associated with traditional chemical synthesis methods. It is a crucial step towards more sustainable manufacturing processes with a positive impact.

The Conagen–Sumitomo partnership leverages Conagen's expertise in microbial strain design and development with Sumitomo Chemical's proficiency in chemical production and commercialization. The collaboration aims to create a platform that enables the production of sustainable chemicals to replace petrochemicals in an extended range of many applications.

PHS is used to produce polymers, resins, and other chemicals. The monomer HS can also be used as an input for the synthesis of other substances, such as pharmaceuticals and fragrances. The applications of HS and PHS are limitless and can span uses from electronics to personal care and other consumer products.

"This partnership represents a significant step forward in pursuing green chemicals for sustainable material production,” said J. McNamara, Ph.D., V.P. of chemical applications at Conagen. “Our commitment is a testament to the power of collaboration and the potential of combining our technologies with synthetic and polymer chemistries to create innovative, sustainable solutions that can significantly reduce petroleum–based products in the environment,” McNamara stated. "Together, we're marking a new era of carbon–neutral material production efforts.”

The monomer HS, with the chemical formula C8H8O, is a derivative of styrene in which a hydroxyl group (–OH) is attached to the aromatic ring's para position (carbon atom 4). The HS and PHS are examples of green chemistry for minimizing waste, reducing hazardous chemicals, and using catalysts that can be easily separated and reused. This joint development project promises to potentially pave the way for developing novel renewable and sustainable materials. "Similar technology can be used to produce other key chemical ingredients by fermentation at industrial scale, such as cinnamic acid, monohydroxy–benzoic acid, and dihydroxy–benzoic acid," said McNamara.

###

About Conagen

Conagen is making the impossible possible. It is a product–focused, synthetic biology R&D company with large–scale manufacturing service capabilities. Its proprietary strain development, fermentation, and scale–up technologies enhance our partners' sales, production, and profitability across a broad spectrum of current and developing markets in food, beverage, nutrition, flavor and fragrance, pharmaceutical, and renewable materials.

About Sumitomo Chemical

Sumitomo Chemical is Japan's leading chemical company, with a global presence in the chemicals, petrochemicals, and plastics industries. The company is committed to sustainability and has a product portfolio contributing to the United Nations Sustainable Development Goals.Top of Form

Attachments


GLOBENEWSWIRE (Distribution ID 8884420)

Sri Lanka: Right Turn, Wrong Move

The tea-pluckers with their wet-weather gear at Blue Field tea estate in Ramboda, Sri Lanka. Amid a looming food security crisis linked to Sri Lanka’s cost-of-living crunch, the country’s most vulnerable breadwinners wonder how much longer they can cope, as the Government battles the nation’s worst economic crisis since independence in 1948. November 2022. Credit: UN News/Daniel Johnson

By Neville de Silva
LONDON, Aug 1 2023 – When this Indian Ocean- island gained independence from Britain in 1948 after some 450 years of colonial rule under three western powers, it was simply named the “Dominion of Ceylon”.

This country which was granted universal franchise nearly two decades before independence was seen as one of Asia’s first democracies-if not the first.

Sadly, that reputation has fast faded.

Today, that right to vote is being denied with even elections to local bodies been halted for dubious reasons including the lack of state funds. The Supreme Court issued an interim order asking that funds be made available for the election. ruling.

That order was simply ignored. Instead, the ruling Sri Lanka People’s Front (SLPP) MPs threatened to summon the judges to parliament for allegedly violating their privileges

The most recent is a desperate move by one government MP to move a private member’s motion to have parliament vote to let the expired bodies continue in the absence of elections.

Fortunately, the Attorney-General informed the Speaker that such a move was unconstitutional and so would require a two-third majority vote and perhaps a referendum. That shut the door on this piece of frippery.

The government’s concern is understandable. It is led by a stand-in president of one party propped up in parliament by a majority from a one- time political enemy the SLPP, now living a symbiotic political existence.

Neither of them wants an election even at the lowest levels of governance for fear of what the results might signify. Negative results would sound alarm bells ahead of the presidential elections next year and parliamentary elections the year after, though the president could call parliamentary elections earlier.

Those who would look back at Sri Lankan political history since 1977 might well wonder whether current president Ranil Wickremesinghe, filling in until November next year for predecessor Gotabaya Rajapaksa who resigned after fleeing public wrath, has taken a page out of his uncle Junius Richard Jayewardene’s book of political Machiavellianism.

But if “Yankee Dicky”, as Jayewardene was called from his early days for his pro-American foreign policy views and his capitalist economic outlook, took a turn to the right when he came to power in 1977, his nephew has taken a sharper turn in that direction, his neoliberal views meshing with the IMF rescue programme intended to pull the country out of the economic mess that Gotabaya Rajapaksa created during his short presidency.

Yet Wickremesinghe’s path to economic resuscitation is strewn with political and working- class casualties against whom some of the most abrasive laws in the country’s statute books have been employed, such as the Prevention of Terrorism Act (PTA).

International conventions such as the ICCPR have been stood on its head to detain dissidents and clamped down on public protests and other rights guaranteed under the constitution that his uncle imposed on the country.

If the IMF agreement calls for the government to sell the family silver, as Wickremesinghe’s offer of even profit- making state- owned enterprises and other state assets to foreign and local investors suggest, this is bound to adversely affect employment adding to the amounting joblessness in recent years following the Covid pandemic and President Rajapaksa’s misguided economic policies.

Besides this, a new Labour law that would repeal some 28 existing laws granting workers’ rights won over the years through hard struggles by leftist trade unions and political parties, would be replaced by stringent new laws heavily weighted in favour of employers.

The proposed labour laws now been waved about by an over-enthusiastic Labour Minister hoping to please the president and the business community will, if not challenged before the Supreme Court, will jettison many long existing workers’ rights to create a comfortable environment for prospective foreign investors and the government’s business cronies.

A new anti-terrorism law, more abhorrent than the PTA, has drawn heavy flak both at home and internationally. An anti-corruption law has just been passed, more to satisfy the IMF than to catch the crooks, particularly politicians who fattened themselves over the years. Though Sri Lanka already has stringent laws not even a fistful of politicians have been prosecuted and convicted for bribery and corruption.

Meanwhile the country is facing a huge brain drain. Since 2022 some 700 or so doctors, specialists and medical staff have left for employment abroad. So have other professionals including engineers, IT specialists, airline pilots and technicians.

Education Minister Susil Premajayantha admitted in parliament the other day that 255 university academics and some 150-odd non- academic staff have vacated posts since last year.

Furthermore, UN reports have pinpointed the rise of poverty in the country with families and school children skipping meals because people cannot afford the high prices for domestic essentials like electricity.

The Agriculture Minister was warning the other day about the possibility of poor harvests in the coming season which, if sadly it does happen, could lead to food shortages

The seeming political stability with no queues and no demonstrators, should not be misconceived. While Wickremesinghe’s governing alliance in which fissures have been more conspicuous recently, prepares the ground to welcome foreign and local capitalist entrepreneurs, the same ground is being cut under the feet of the vast majority who survived all these years on their meagre earnings and now are struggling to survive.

In 1972, the then coalition government led by the world’s first woman prime minister Sirimavo Bandaranaike which came to power two years earlier, made the final constitutional break with Britain, dropping the British monarch as its head of state and declaring the country as the “Republic of Sri Lanka”. It maintained the Westminster-style parliamentary system it was accustomed to.

That government was roundly defeated at the 1977 general election. The right-wing United National Party (UNP) under its new leader Jayewardene, popularly called “JR”, won an unprecedented five-sixth majority in parliament driving Mrs Bandaranaike’s SLFP to a single digit presence.

Jayewardene decided the country needed a new constitution. But it was drafted without any public consultation whereas the 1972 constitution was drafted by parliament meeting separately as a constituent assembly.

Jayewardene named himself president and was sworn-in on 4th February 1978 under a new executive presidential system. The name of the country was changed into an ostentatious “Democratic Socialist Republic of Sri Lanka”.

Armed with enormous powers and a party with a five-sixth majority in parliament Jayewardene said the only thing he could not do was to change a man into a woman and vice versa.

The new name for Sri Lanka was a tragic misnomer. It did not take long for Jayewardene to show that he was neither democratic nor socialist. He set up a presidential commission which hauled up former prime minister Sirimavo Bandaranaike, her closest minister Felix Dias Bandaranaike and others before it for alleged corruption and abuse of power. They were stripped of their civic rights, eliminated from political activity for seven years.

The president was more concerned about preserving his huge majority in parliament fearing that a general election would see a resurrected opposition returning in larger numbers.

In a move unheard of in democratic governance, President Jayewardene obtained signed letters of resignation from parliament from all his 140 MPs. The one thing missing was the date which the president would fill in if required. That was Jayewardene’s Damocles-ean Sword suspended over his own MPs.

The biggest blot on Jayewardene’s escutcheon is the bloody events of July 1983 when minority Tamils in Colombo and around the country were physically attacked and some 3000, according to reports were killed, their houses burnt and the businesses destroyed and looted. Thousands were made refugees in their own country or abroad.

The immediate cause for this horrendous and tragic happening 40 years ago was said to be the killing of 13 soldiers by Tamil insurgents in the north.

But when the attacks on Tamils and their homes really unfolded on July 25, as I witnessed that day and later, there were clear signs of government involvement. The fact that neither the president nor any minister appeared on TV calling a halt to this ethnic convulsion spoke volumes.

When the government did finally speak about four days later, it claimed the attacks were the “spontaneous outburst of Sinhala wrath” at the killing of the soldiers.

But with international community critical at the government’s inaction to stop the carnage, Jayewardene swiftly changed tack. The government claimed there was a “Naxalite” conspiracy to assassinate government figures and overthrow the government. A foreign hand-unnamed- was involved, it said.

Jayewardene evoked the Public Security Act to round up opposition politicians he feared were growing in popularity and throw them in jail and sealed the Communist Party newspaper. I remember my friend John Elliot of the “Financial Times” calling it “a crude cover up” while other foreign journalists simply dismissed the story.

What does matter now is that right through these events of the Jayewardene years, Sri Lanka’s current President Ranil Wickremesinghe, Jayewardene’s nephew, was a faithful member of his uncle’s cabinet and possibly privy to what went on inside.

In fact, if I remember correctly, he made a speech in parliament on the so-called “Naxalite” plot.

There is one essential difference. JR served two terms as president. His nephew lost two presidential elections and yearns to be at elected president at least once.

Next March he will be 75. Would he then be at the door step of the Last Chance Saloon? If so how far would he go to make sure he becomes and elected president like his uncle before retires from politics.

The United National Party (UNP) that his uncle represented and he does now, was called the Uncle Nephew Party from its early days. We shall see before long, won’t we.

Neville de Silva is a veteran Sri Lankan journalist who held senior roles in Hong Kong at The Standard and worked in London for Gemini News Service. He has been a correspondent for the foreign media.

IPS UN Bureau

 


!function(d,s,id){var js,fjs=d.getElementsByTagName(s)[0],p=/^http:/.test(d.location)?’http’:’https’;if(!d.getElementById(id)){js=d.createElement(s);js.id=id;js.src=p+’://platform.twitter.com/widgets.js’;fjs.parentNode.insertBefore(js,fjs);}}(document, ‘script’, ‘twitter-wjs’);  

Scramble For Africa: It’s Not 1884 All Over Again, Is It?

Credit: Angela Umoru-David

By Angela Umoru-David
ABUJA, Aug 1 2023 – Not all wars are fought on the battleground. The Cold War has taught us that certain wars could go on for decades, without overt violence. Perhaps, we are in the middle of another one with China as the new rival to the United States of America. This time, the ‘battlefield’ is Africa.

This Voice of America article speaks on how China is already outpacing the U.S. in its relations with the continent. New York Times cites loans provided by the Chinese government to several African nations and investments such as hospitals, transportation infrastructure and stadiums already dotting the African landscape.

Similarly, we all know of how the United States has heavily supported many countries in Africa through trade and in the fight against insurgency; putting boots on the ground, supplying top-grade artillery, training security agencies etc.

Why would nations so far removed make decisions for a whole continent? Why does Africa have to be a pawn in a scheme that it has no business with? Why is there even a conversation about strengthening relations with Africa on the basis of having an advantage over another nation?

There is no point in rehashing the dysfunctional relationship Africa has had with… hmmm, what’s the right term? The global north? Developed nations? Let’s just say ‘richer nations’.

Also, there is no need to debate how that wealth came to be. The point is that Africa has, for the longest time, depended on wealthier nations for humanitarian aid and oftentimes, this aid always comes with strings attached.

Recently, I was at an event organized by Devex where Congresswoman Sara Jacobs spoke on US-Africa relations. She made very valid points about how the United States has, over the years, used a carrot-stick approach with the continent, dangling humanitarian aid for alignment with the United States policies and ideologies and sanctions for derelictions (my words, not hers).

She highlighted the positive impact of some of these policies like the African Growth and Opportunity Act (AGOA), which I had not heard of prior to her mentioning it but has yielded interesting returns for Nigeria and the U.S. She went on to caution against the U.S limiting diplomatic relations with Africa to a strategic competition to simply be one-up over China.

Then she said something that got me thinking really hard. She talked about the United States giving Africa agency. In fairness to her, I do not remember the full statement she made and her points of view were largely refreshing to hear but my mind went off on a tangent, pondering a question, “Will the USA ever really accept Africa’s agency, even when we do not agree with them?”

The truth is that Africa does not need any country or ‘superpower’ to give it agency. Absolutely not! Africa is made up of sovereign nations who already have agency and while these nations may not act like it as they go cap-in-hand seeking foreign aid, this is a fact.

All of this made me wonder if it was 1884-1885 all over again- the Berlin Conference that ended with the partitioning of Africa and rules for its conquest.

Why would nations so far removed make decisions for a whole continent? Why does Africa have to be a pawn in a scheme that it has no business with? Why is there even a conversation about strengthening relations with Africa on the basis of having an advantage over another nation?

The goal of this article is not to point accusatory fingers at the United States or China. After all, some of these humanitarian efforts have truly improved certain communities, albeit at a great cost. More so, as our people say, when you point one finger, the others point back at you. What have our leaders done to reposition the continent? How has the continent looked inward to build itself?

The questions abound but I believe this is the start. There are so many development organizations in Africa, but how many of them are thinking of systemic change rather than merely providing direct service?

Do not misunderstand me: direct service is important in bridging immediate gaps to improve the quality of life in various communities. Nonetheless, if we are going to initiate long-term change then we should be thinking of systems change, policy advocacy, looking at the big picture and laying the building blocks for posterity.

Irrespective of the sectors you may be working in- governance, health, education, environment etc.- as you provide services for the ‘now’, you must also have a bird’s eye view of how to improve your community for the long run and eliminate the factors that perpetuate the status quo.

With the expertise you have in your local context, you should be the one directing even international grantmakers on how best to engage communities. This is the concept of localization, that I wrote about here. This is why collaboration and coalition-building in the development space is important. Development work is not a competition even though grantmaking has made it seem that way.

Ultimately, Africa needs to stand up for itself. There is no one coming to save us. Otherwise, we will sit by, twiddle our thumbs and find ourselves back in 1884.

Angela Umoru-David is a creative social impact advocate whose experience cuts across journalism, program design and corporate/development communications, and aims to capture a plurality of views that positively influence the African narrative