Recursion Enters into Agreements to Acquire Cyclica and Valence to Bolster Chemistry and Generative AI Capabilities

SALT LAKE CITY and TORONTO and MONTRÉAL, May 08, 2023 (GLOBE NEWSWIRE) — Recursion (NASDAQ: RXRX), a leading clinical stage TechBio company decoding biology to industrialize drug discovery, today announced it has signed agreements to acquire two companies in the AI–enabled drug discovery space: Cyclica and Valence.

"Recursion has pioneered the massive, parallel generation of –omics data with machine learning in order to map and navigate biology to discover new medicines faster. The strategic acquisitions of Cyclica and Valence add industry–leading capabilities in digital chemistry, as well as machine–learning and artificial intelligence, which combined with our large–scale automated wet–laboratories and supercomputing capabilities, enables us to deploy what I believe is the most complete, technology–enabled drug discovery solution in the biopharma industry. We look forward to showing the world proof of the compounding benefit of this full–stack approach through the rapid acceleration of our pipeline and partnerships. Amidst a rapidly accelerating global race for technology talent, these acquisitions cement Recursion as the center of gravity for the best and brightest in ML and AI who want to reimagine how drugs are discovered," said Chris Gibson, Ph.D., Co–Founder and CEO of Recursion. "I am so excited to welcome the Cyclica and Valence teams to Recursion, especially at such a dynamic moment in history when machine learning and artificial intelligence are creating so much rapid change across every industry."

Cyclica, headquartered in Toronto, has built two highly differentiated products in the digital chemistry space which will be integrated into the RecursionOS. MatchMaker is an AI–enabled deep learning engine that predicts the polypharmacology of small molecules as the foundation for small molecule drug discovery. It is able to generalize across the proteome and uses both AlphaFold2 structures and homology models. POEM (Pareto Optimal Embedding Model) is a unique similarity–based property prediction model. In contrast to other AI prediction models, POEM uses multiple types of molecular fingerprints to describe molecules, providing a much richer measure of similarity that leads to greater accuracy.

"Cyclica and Recursion both believe in the value of industrializing drug discovery," said Naheed Kurji, CEO and Co–Founder of Cyclica. "Combining our proteome–wide prediction of small molecule–target interactions into Recursion's data universe will create one of the largest fit–for–purpose biological and chemical datasets in the drug discovery space. Together, I believe Recursion will have an immense impact on human health in the years to come."

Valence, headquartered in Montral at Mila, the world's largest deep learning research institute, is committed to unlocking the full potential of deep learning in the drug discovery process. The company has pioneered the application of low–data learning in drug design, unlocking the ability to design differentiated small molecules with improved properties and function from datasets too small, sparse, or noisy for traditional deep learning methods. Valence has an unparalleled track record of innovation in molecular machine learning, including best–in–class methods for AI–enabled structural biology, generative chemistry, and multi–parametric optimization, ultimately enabling the design of best–in–class or first–in–class chemistry against challenging biology.

"The integration of Valence's powerful AI–based chemistry engine into Recursion's diverse and data–rich operating system will help unlock the true power of AI–first digital chemistry and drug discovery," said Daniel Cohen, CEO and Co–founder at Valence Discovery. "Recursion is a leader in technology–enabled drug discovery with a proven track record of leveraging data to uncover novel biology, and I'm thrilled for our teams to join forces and combine our respective strengths to rapidly advance new medicines to patients who need them."

Joining forces with Recursion's Montral deep learning research office, Valence will become an artificial intelligence and machine learning research center to be led by Daniel Cohen with continued advisory from Yoshua Bengio.

"The acquisition of Valence gives Recursion the opportunity to create a true center of excellence for some of the most compelling AI/ML research in the world," said Yoshua Bengio, deep learning pioneer and scientific advisor to both Recursion and Valence. "With this newly integrated group housed in the Mila ecosystem, Recursion's team of researchers in AI and ML for drug discovery reaches a critical mass at a crucial time in the development of new AI algorithms for scientific discovery."

Terms of the Acquisitions

Recursion has entered into agreements to acquire Cyclica for a purchase price of $40 million and Valence for a purchase price of $47.5 million, in each case subject to customary closing and post–closing purchase price adjustments. The purchase price in the acquisitions will be payable in the form of shares of Recursion Class A common stock, shares of a subsidiary of Recursion exchangeable for shares of Recursion's Class A common stock and the assumption of certain outstanding Valence and Cyclica options. In certain limited circumstances, Recursion may pay nominal cash consideration to Valence and Cyclica shareholders in lieu of such exchangeable shares or Recursion Class A common stock. Recursion expects no material change to its cash runway as a result of these acquisitions. Recursion expects both acquisitions to be completed in the second quarter of 2023, subject to applicable closing conditions.

About Recursion
Recursion is a clinical stage TechBio company leading the space by decoding biology to industrialize drug discovery. Enabling its mission is the Recursion OS, a platform built across diverse technologies that continuously expands one of the world's largest proprietary biological and chemical datasets. Recursion leverages sophisticated machine–learning algorithms to distill from its dataset a collection of trillions of searchable relationships across biology and chemistry unconstrained by human bias. By commanding massive experimental scale "" up to millions of wet lab experiments weekly "" and massive computational scale "" owning and operating one of the most powerful supercomputers in the world, Recursion is uniting technology, biology and chemistry to advance the future of medicine.

Recursion is headquartered in Salt Lake City, where it is a founding member of BioHive, the Utah life sciences industry collective. Recursion also has offices in Toronto, Montral and the San Francisco Bay Area. Learn more at www.Recursion.com, or connect on Twitter and LinkedIn.

About Cyclica
As a neo–biotech, Cyclica is efficiently advancing an industry–leading, robust and sustainable drug discovery portfolio focused on CNS, oncology, and auto–immune diseases. Cyclica has built the only generalizable platform across the entire proteome, expanding the target space for low–data targets, including AlphaFold2 structures, PPIs, and mutant oncogenic targets. Cyclica has brought together a diverse and experienced team of biologists, chemists, computer scientists, and business professionals who are collectively passionate about changing the drug discovery paradigm. By exploring the unexplored, and drugging the undrugged, Cyclica strives to impact patient health like never before. For more information, please visit: www.cyclicarx.com.

About Valence Discovery
Valence is harnessing a revolution in computation to improve human health. The company is a leader in developing and deploying AI and physics–based technologies to enable the design of differentiated small molecules with improved properties and function. Following successful partnerships with leading biotech and pharmaceutical companies, and an unparalleled track record of innovation featured in top AI journals and conferences, Valence has built a team of interdisciplinary industry veterans and computational experts focused on rapidly advancing a portfolio of internal drug discovery programs. Valence launched publicly in 2021, is supported by leading biotech and deeptech investors, and is headquartered in Montral. To learn more, please visit www.valencediscovery.com.

Media Contact

Media@Recursion.com

Investor Contact
Investor@Recursion.com

Forward–Looking Statements
This document contains information that includes or is based upon “forward–looking statements” within the meaning of the Securities Litigation Reform Act of 1995, including, without limitation, those regarding the timing and completion of the Cyclica and Valence acquisitions and the outcomes and benefits expected from such acquisitions; Recursion OS and other technologies; business and financial plans and performance, including cash runway; and all other statements that are not historical facts. Forward–looking statements may or may not include identifying words such as "plan," "will," "expect," "anticipate," "intend," "believe," "potential," "continue," and similar terms. These statements are subject to known or unknown risks and uncertainties that could cause actual results to differ materially from those expressed or implied in such statements, including but not limited to: challenges inherent in pharmaceutical research and development, including the timing and results of preclinical and clinical programs, where the risk of failure is high and failure can occur at any stage prior to or after regulatory approval due to lack of sufficient efficacy, safety considerations, or other factors; our ability to leverage and enhance our drug discovery platform; our ability to obtain financing for development activities and other corporate purposes; the success of our collaboration activities; our ability to obtain regulatory approval of, and ultimately commercialize, drug candidates; our ability to obtain, maintain, and enforce intellectual property protections; cyberattacks or other disruptions to our technology systems; our ability to attract, motivate, and retain key employees and manage our growth; inflation and other macroeconomic issues; and other risks and uncertainties such as those described under the heading "Risk Factors" in our filings with the U.S. Securities and Exchange Commission, including our Annual Report on Form 10–K. All forward–looking statements are based on management's current estimates, projections, and assumptions, and Recursion undertakes no obligation to correct or update any such statements, whether as a result of new information, future developments, or otherwise, except to the extent required by applicable law.


GLOBENEWSWIRE (Distribution ID 8833750)

Can African Farmers Still Feed the World?

Droughts are a growing threat to global food production, particularly in Africa. Credit: Busani Bafana/IPS

Droughts are a growing threat to global food production, particularly in Africa. Credit: Busani Bafana/IPS

By Baher Kamal
ROME, May 8 2023 – Less than a decade ago, Africa was home to 60-65% of the world’s uncultivated arable land and 10% of renewable freshwater resources, as reported by the African Union in 2016, while concluding that African farmers could feed the world.

Is it still the case?

The above data had been provided in July 2016 by the NEPAD (New Partnership for Africa’s Development), the technical body of the African Union (AU).

Now that seven long years have elapsed, the second largest continent on Earth –after Asia– has been facing too many extraneous pressures and hazards.

A major consequence is that that very percentage (60-65%) of the world’s uncultivated and arable land is now affected by degradation, with nearly three million hectares of forest lost… every single year.

 

Great walls

The steadily advancing degradation and desertification of major African regions have led the continent to build great green walls.

One of them – the Great Green Wall, is the largest living structure on the Planet, one that stretches over 8.000 kilometres across Africa, aiming at restoring the continent’s degraded landscapes and transforming millions of lives in the Sahel, and ushering in a new era of sustainability and economic growth.

Launched in 2007 by the African Union, this African-led Great Green Wall Initiative. The project is being implemented across 22 African countries and is expected to revitalise thousands of communities across the continent.

It is about “helping people and nature cope with the growing impact of the climate emergency and the degradation of vital ecosystems, and to keep the Sahara desert from spreading deeper into one of the world’s poorest regions,” according to the UN Environment Programme (UNEP).

Vast tracts of land along the Great Green Wall have already been restored by local communities. And so far, 80% of the 19 billion US dollars have been pledged, as reported by the UN Convention to Combat Desertification (UNCCD).

 

But not enough…

The extraneous factors that have been pushing Africa towards the abyss of extremely severe droughts, unprecedented floods, the advancing degradation of its land and water resources, have led this continent on Earth to rush to build more and longer and larger walls.

For instance, the Southern Africa region is currently busy preparing a similar programme, with all 16 countries in the Southern African Development Community (SADC) committed to accelerating multi-sectoral transformation through a regional initiative inspired by the Great Green Wall in the Sahel, or SADC Great Green Wall Initiative (GGWI).

The SADC member countries are: Angola, Botswana, Comoros, DR Congo, Eswatini, Lesotho, Madagascar, Malawi, Mauritius, Mozambique, Namibia, Seychelles, South Africa, Tanzania, Zambia and Zimbabwe.

 

A wall for Southern Africa

Their Initiative aims to create productive landscapes in the Southern Africa region that contribute to regional socially inclusive economic prosperity and environmental sustainability.

Together with member countries and key partners the goal is to initiate multi sectoral partnerships and to acquire pledges of an indicative 27 billion US dollars by 2025.

 

10 Million square kilometres at risk of desertification

Covering a total land area of 10 million square kilometres, Southern Africa faces immediate effects of desertification, land degradation and drought, as well as challenges driven by climate change, biodiversity loss, and unsustainable development practices in agriculture, energy and infrastructure sectors, reports the UN Convention to Combat Desertification (UNCCD).

“The Great Green Wall is part of a broader economic and development plan – if we restore land but are not able to reap the benefits of that healthy and restored land due to lack of access to renewable energy and infrastructure, hindering access to markets and livelihoods, then we are only halfway there with our vision,” on this said UNCCD’s Louise Baker.

 

And a great wall for the Middle East

In addition to the above two new natural wonders, there is another one: the Middle East Green Initiative, a regional effort led by Saudi Arabia to mitigate the impact of climate change on the region and to collaborate to meet global climate targets.

 

50 billion trees

It aims at planting 50 billion trees across the Middle East, equivalent to 5% of the global afforestation target, and to restore 200 million hectares of degraded land.

A fifth (10 billion) trees will be planted within Saudi Arabia’s borders, with the remaining 40 billion set to be planted across the region in the coming decades.

The trees will also provide numerous other benefits, including stabilising soils, protecting against floods and dust storms and helping reduce CO2 emissions by up to 2.5% of global levels.

Across the Middle East and North Africa, extreme weather events including droughts and heavy rains will become more common in the region if global temperatures continue to increase, according to the Saudi-led project.

 

A green corridor for East Africa… and elsewhere

In addition to developing an Eastern Africa corridor soon, other similar initiatives under the umbrella of the African Union’s NEPAD are ongoing, such as the African Forest Landscape Restoration Initiative (AFR100).

In 2015, AFR100 was founded in Durban by a group of 10 African countries, each committing to restore a certain number of hectares of degraded landscapes within their borders.

Twenty-eight African countries have now committed to restoring 113 million hectares, which, if achieved, will exceed the initiative’s namesake goal of 100 million hectares across the continent under restoration by 2030.

 

Not only trees

Forest landscape restoration is more than just planting trees,” said Mamadou Diakhite, leader of the AFR100 Secretariat.

On a continent that is expected to account for half the global population growth by 2050, reducing and sequestering greenhouse gas emissions is a welcome byproduct of returning those natural landscapes to health and profitability; but it’s not the first focus, reported Gabrielle Lipton, Landscape News Editor-in-Chief.

“Restoring landscapes that have been degraded by the effects of climate change and human development through planting trees and encouraging sustainable farming and herding must first and foremost provide food, jobs and homes for people, as well as preserve their cultures that are based on the products of their lands.”

Moreover, as more than 1 in 5 people in Africa are undernourished, and forced migration across country borders increases due to climate change and conflict, African economies continue to struggle hard to create jobs for young people.

Any chance that Africa recovers soon from the impacts of so much extraneous damage, which this continent of nearly 1.4 billion humans continues to struggle to reverse?

New Mosquito Species Could Derail Fight Against Malaria

Stagnant water in one of Nairobi’s residential areas. Credit: Wilson Odhiambo/IPS

Stagnant water in one of Nairobi’s residential areas. Credit: Wilson Odhiambo/IPS

By Wilson Odhiambo
NAIROBI, May 8 2023 – ‘Urban’ Kenya has been alerted because new mosquito species, Anopheles stephensi, threatens to derail decades of effort made in the fight against malaria.

According to a report by experts from the Kenya Medical Research Institute (KEMRI), the species was first noted during routine mosquito surveillance in Saku and Laisamis villages in Marsabit County. The report states that, unlike the traditional mosquito vector, the Anopheles stephensi can adapt to man-made habitats that include plastic containers, discarded car tyres and open sewer lines—this makes urban centres a hot spot for their prevalence.

Anopheles stephensi is endemic to South Asia and Arabian Peninsula, where it is a known carrier for two malaria variants Plasmodium falciparum and P. vivax. It was first noted at the Horn of Africa ten years ago in Djibouti, after which it was later tracked down in Ethiopia, Somalia, and Sudan in 2019.

The species is also known to survive through different climatic conditions, which can enable it to cause problems all year round if left uncontrolled.

‘’This mosquito most likely spreads through ships coming in from Asia since genetic analysis of many of the samples collected in Africa shows they are closely related to those found in Asia. Once they got to Africa, it is highly likely they have been transported southwards on the road,’’ said Dr Eric Ochomo, the project’s lead researcher and an entomologist at the KEMRI, Kisumu.

‘’It breeds in a wide range of habitats, mostly water storage containers that are not covered, manholes, overhead tanks, poorly dumped plastic containers etc.’’

Malaria has been a perennial problem in Kenya and Africa, given the vast tropical conditions that favour mosquitos and unreliable health facilities that make its control and treatment an almost impossible hurdle.

While being a nuisance in Africa, most malaria cases and mortalities have been recorded in rural areas, characterized by a lack of adequate medical amenities, unreliable infrastructure, and a lack of knowledge among residents.

Urban areas have usually been spared the malaria burden due to access to proper medical facilities and a good understanding of the disease and how to control and prevent it.

This notion may, however, change for the worse as this new mosquito species threatens the demographics and steps made in the fight against malaria in Africa.

‘’This species is different from the traditional mosquito for two main reasons; A) its diversity of breeding habitats means it can breed in rural and urban settings alike, which means that it is not restricted to rural habitats like the Anopheles gambiae, Anopheles arabiensis and Anopheles funestus which are the most common vectors in Kenya at the moment. B) It can transmit both Plasmodium falciparum and Plasmodium vivax parasites. We currently have very low levels of P. vivax transmission in Kenya, and this could be increased by this vector,’’ Ochomo explained to IPS.

Despite the 2020 world malaria report showing a significant decrease in malaria deaths over the past two decades (from 84 percent in 2000 to 67 percent in 2019), it remains one of Africa’s leading causes of death, especially among pregnant women and children under the age of five.

The report stated that 51 percent of the global malaria deaths were in Africa, with Burkina Faso (4%), the Democratic Republic of the Congo (11 percent), Nigeria (23 percent), Mozambique (4 percent), Niger (4 percent) and Tanzania (5 percent).

In Kenya, most malaria cases are centred around the malaria endemic areas, including the coastal and lake regions, which form prime breeding spots for female anopheles mosquitos. For the cases reported in towns such as Nairobi, a follow-up on the patient’s movements often reveals that they recently visited or through one of these malaria-endemic places and got infected.

A researcher from KEMRI’s Entomology Department tests stagnant water for the new species of mosquito. Credit: KEMRI’s Entomology Department

A researcher from KEMRI’s Entomology Department tests stagnant water for the new species of mosquito. Credit: KEMRI’s Entomology Department

According to the Centers for Disease Control (CDC), about 3.5 million malaria cases are reported in Kenya annually, with about 10,700 mortalities. Out of this, western Kenya (lake region) usually records the highest number of cases at 45 percent.

The lake and coastal regions are categorized as malaria-endemic due to the favourable temperature and humid conditions they provide for mosquito breeding.

With most people in central Kenya and the highland areas having little exposure to malaria infections, this new vector could prove problematic given their immune system’s primitiveness to the disease.

The 2020 Kenya malaria indicator report says that low-risk malaria areas include Nairobi, Nyandarua, Nyeri, Kirinyaga, Murang’a, Kiambu, Machakos, Makueni, Laikipia, Nakuru, and Meru. Most of these areas are considered urbanized compared to most parts of Kenya.

Seasonally, areas that experience malaria outbreaks include Tana River, Marsabit, Isiolo, Meru, Garissa, Wajir, Mandera, Turkana, Samburu, Baringo, Elgeyo Marakwet, Kajiado. This is mainly due to the arid and semi-arid conditions experienced throughout the year that do not favour mosquito breeding.

‘’What this means is that we are going to have more incidences of malaria because this vector can thrive in both rural and urban settings and many other geographical regions,’’ says Dr Alex Owino, Medical Superintendent, Katulani Sub-County Hospital, Kitui.

‘’Kitui county falls under the low-risk malaria areas, with the few cases recorded being mainly from patients who had recently travelled outside the county,’’ he told IPS.

Owino explained that controlling malaria was easy when there were specific places where the host mosquito was known to favour. However, with this new vector being able to spread widely, it becomes a threat to the efforts made in the fight against malaria.

Being a developing country, parts of urban Kenya are characterized by poorly planned housing facilities, inadequate drainage systems and poor waste disposal management. Nairobi, for instance, is also known for hosting the largest slum in the country, Kibera, coupled with the Nairobi dam, which has, for years, made the headlines for having all manner of pollution destroying it.

All these conditions have been a recipe for various diseases, such as cholera and typhoid, causing health problems, especially in the slum areas. Now, malaria may have just added to the burden that these town dwellers have to deal with.

Ochomo said that, unlike the traditional malaria-causing mosquitoes, Anopheles gambiae and Anopheles funfests, the Anopheles stephensi is an invasive species that could bring malaria transmission to these areas where there is a large number of naive (have never had malaria) individuals.

‘’These individuals could get far more severe symptoms than people who have been exposed since birth,’’ he told IPS.

Wilson Opudo, a public health and infectious diseases specialist, also believes that the ongoing changes in climate conditions are likely to increase the malaria burden by creating mosquito breeding zones in areas where they were not a concern.

‘’Despite malaria being known to favour certain parts of Kenya, the recent changes in climate which have resulted in temperature increase and hydrological changes may help form new areas for the malaria vector breeding thus bringing malaria to places where it initially did not exist,’’ Opudo told IPS.

‘’This will put a lot of pressure on the malaria control commodities currently available for the endemic areas of Africa and could result in increased disease burden,’’ he added.

Ochomo concluded that its presence in urban settings means controlling this new vector will rely on properly managing waste disposal, covering water containers, and draining stagnant water.

‘’There is very little information available on the behaviour of the adult mosquitoes and an urgent need to invest in the research on this to inform what control methods would be applicable for the adult mosquitoes,’’ said Ochomo.

IPS UN Bureau Report

 


!function(d,s,id){var js,fjs=d.getElementsByTagName(s)[0],p=/^http:/.test(d.location)?’http’:’https’;if(!d.getElementById(id)){js=d.createElement(s);js.id=id;js.src=p+’://platform.twitter.com/widgets.js’;fjs.parentNode.insertBefore(js,fjs);}}(document, ‘script’, ‘twitter-wjs’);  

Recursion توقّع اتفاقيات استحواذ على Cyclica وValence بهدف تعزيز قدراتها في الكيمياء والذكاء الاصطناعي الإنشائي

سالتليك سيتي وتورونتوومونتريال،8مايو2023(GLOBE NEWSWIRE)‏ — شركة Recursion (بورصة ناسداك:RXRX)،رائدة التقنياتالحيوية السريريةالمُستخدمةفي تطوير صناعةاكتشاف الأدويةبالاستعانةبتحليل الشفراتالحيوية، أعلنتاليوم توقيعهااتفاقيات للاستحواذعلى شركتينتعملان في مجالاكتشاف الأدويةالمُدعم بالذكاءالاصطناعيهماCyclica و Valence.

قالكريس جيبسون،المؤسس المشاركوالرئيس التنفيذيلـ Recursion،والحاصل علىدرجة الدكتوراه"كانلـ Recursionدورًارائدًا في الإنشاءالهائل والمتوازيلبيانات دراساتالعلوم الحيويةباستخدام التعلمالآلي، وذلكمن أجل رسم خرائطلعلم الأحياءوتسهيل الاطلاعفيه، بهدف تسريعاكتشاف الأدويةالجديدة.ويمكنناتقديم ما أعتقدأنه الحل الأكثرشمولًا لاكتشافالأدوية المُدعمبالتكنولوجيافي قطاع الأدويةالحيوية، وذلكبفضل الاستحواذالإستراتيجيعلى CyclicaوValenceوماتضيفانه منقدرات رائدةفي القطاع فيمجالات الكيمياءالرقمية والتعلمالآلي والذكاءالاصطناعي،إضافة إلى مانزخر به من المختبراتالتجريبيةالآلية واسعةالنطاق وقدراتالحوسبة الفائقة.نتطلعإلى أن نظهرللعالم الأدلةعلى الفوائدالمضاعفة لهذاالنهج المتكاملبتسريع عملياتالإنتاج والشراكاتلدينا.وفيخضم التنافسالعالمي المتسارعلجذب البارعينفي ميدان التكنولوجيا،يرسخ الاستحواذمكانة Recursionبوصفهامركز ثقل لأفضلالكوادر وألمعهافي مجالي التعلمالآلي والذكاءالاصطناعي الذينيرغبون في وضعتصور جديد لطرقاكتشاف الأدوية.تغمرنيالحماسة للترحيببفرق CyclicaوValenceفيRecursion،لا سيما في هذهاللحظة التاريخيةالفارقة بماتشهده من متغيراتسريعة في القطاعاتكافة بفضل التعلمالآلي والذكاءالاصطناعي".

قدمتشركة Cyclica،التي يقع مقرهاالرئيسي فيتورنتو، منتجَينمتميزين للغايةفي مجال الكيمياءالرقمية سيُدمجانفي RecursionOSيتنبأمحرك التعلمالعميق المدعومبالذكاء الاصطناعيMatchMaker™‎بعلمالأدوية المتعددللجزيئات الصغيرةكنقطة انطلاقلاكتشاف الأدويةالجزيئية الصغيرة،حيث يمكنه التعميمعبر البروتيوم،كما أنه يستخدمبنيات AlphaFold2ونماذجالتماثل.POEM™‎ (نموذجباريتو للتضمينالأمثل)نموذجفريد للتنبؤبالخصائص بناءًعلى أوجه التشابه.وعلىعكس نماذج التنبؤالأخرى، يصفنموذج POEMالجزيئاتباستخدام أنواعمتعددة من بصماتالأصابع الجزيئية،مما يوفر مقياسًاأكثر تنوعًاللتشابه ويعززمستوى الدقة.

قالنهيد كورجي،الرئيس التنفيذيوالمؤسس المشاركلـ Cyclica:"إنكلًا من CyclicaوRecursionمتفقتانعلى أهمية تطويرصناعة اكتشافالأدوية"وأضاف:"سيتمإنشاء واحدةمن أكبر مجموعاتالبيانات الحيويةوالكيميائيةالملائمة للغرضفي مجال اكتشافالأدوية من خلالالجمع بين تنبؤناعلى مستوى البروتيومللتفاعلاتالمستهدفةللجزيئات الصغيرةوعالم بياناتRecursion.وأعتقدأنه بهذا التعاونسيكون لـ Recursionتأثيرأكبر على صحةالإنسان علىمدى السنواتالقادمة".

يقع المقرالرئيسي لشركةValenceفيمونتريال فيMila،وهو أكبر معهدلأبحاث التعلمالعميق في العالم.وتكرسالشركة جهودهالإطلاق العنانللإمكاناتالكاملة للتعلمالعميق في عمليةاكتشاف الأدوية.أدتالشركة دورًارائدًا في تطبيقالتعلم القائمعلى البياناتالضئيلة فيتصميم الأدوية،فضلًا عن إطلاقالعنان لإمكاناتتصميم جزيئاتصغيرة متمايزةبخصائص ووظائفمحسّنة من مجموعاتالبيانات المتفرقةأو غير متجانسةأو الضئيلةللغاية لطرقالتعلم العميقالتقليدية.وتتمتعValenceبسجلحافل من الابتكاراتفي مجال التعلمالآلي الجزيئي،من بينها أفضلالتقنيات فيفئتها للأحياءالهيكلية المُدعمةبالذكاء الاصطناعي،والكيمياءالتوليدية،والتحسين متعددالمعامِلات،الأمر الذيمكَّن في نهايةالمطاف من تصميمكيمياء هي الأفضلأو الأولى فيفئتها في مقابلالأحياء الصعبة.

صرحدانيال كوهين،الرئيس التنفيذيوالمؤسس المشاركلـ Valence Discovery:"دمجمحرك الكيمياءالفعال القائمعلى الذكاءالاصطناعي لدىValenceفينظام التشغيلالمتنوع الغنيبالبيانات لدىRecursionسيساعدفي إطلاق عنانالإمكاناتالقصوى للكيمياءالرقمية واكتشافالأدوية اللذينيأتي الذكاءالاصطناعي فيأولويتهما".وأضاف:"شركةRecursionرائدةفي مجال اكتشافالأدوية المُدعمبالتكنولوجيا،ولديها سجل حافلمن تسخير البياناتلاكتشاف آفاقحيوية جديدة،ويسعدني أن تتحدفرقنا وتجمعقواها من أجلابتكار أدويةجديدة بسرعةللمرضى الذينيحتاجون إليها".

وبالتعاونمع مكتب أبحاثالتعلم العميقالتابع لـ Recursionفيمونتريال، ستصبحValenceمركزًالأبحاث الذكاءالاصطناعيوالتعلم الآليتحت قيادة دانيالكوهين وبتوجيهاتيوشوا بنجيوالمستمرة.

قاليوشوا بنجيو،رائد مجال التعلمالعميق والمستشارالعلمي لكل منRecursionوValence:"الاستحواذعلى Valenceيتيحالفرصة لـ Recursionلإنشاءمركز امتيازحقيقي لبعض منأبحاث الذكاءالاصطناعي/التعلمالآلي الأكثرإقناعًا فيالعالم".وأضاف:"بالتعاونمع هذه المجموعةالمتكاملةحديثًا والموجودةبمنظومة Mila،سيصل فريق Recursionمنالباحثين فيمجالي الذكاءالاصطناعيوالتعلم الآليفي وقت حاسم إلىمستوى مهم فيتطوير خوارزمياتذكاء اصطناعيجديدة للاكتشافالعلمي".

شروطالاستحواذ

وقعتشركة Recursionاتفاقياتللاستحواذ علىكل من شركة Cyclicaمقابلسعر شراء قدره40مليوندولار وشركةValenceمقابلسعر شراء قدره47.5مليوندولار، وذلكرهنًا في كلحالة بالتعديلاتالعادية التيتطرأ على سعرالشراء عندالإغلاق ومابعد الإغلاق.سيتمدفع سعر الشراءفي عمليتي الاستحواذفي شكل أسهمعادية من الفئةAالعائدةلشركة Recursion،وأسهم شركةتابعة لشركةRecursionقابلةللاستبدال بأسهمعادية من الفئةAعائدةلشركة Recursion،مع افتراض بعضالخيارات المعلقةلشركتي ValenceوCyclica.وقدتدفع Recursionفيبعض الظروفالمحدودة مقابلًانقديًا رمزيًالمساهمي ValenceوCyclicaبدلاًمن الأسهم العاديةالقابلة الاستبدالأو الأسهم العاديةمن فئة Aالعائدةلشركة Recursion.لاتتوقع Recursionأيتغيير جوهريفي المدرج النقديلديها نتيجةلعمليتي الاستحواذهذه، وتتوقعأن يتم الانتهاءمن عمليتي الاستحواذفي الربع الثانيمن عام 2023،رهنًا بشروطالإغلاق المعمولبها.

نبذةعن Recursion
Recursionشركةرائدة في مجالالتكنولوجياالحيوية فيالمرحلة السريريةتعمل على تصنيععملية اكتشافالأدوية عن طريقتحليل الشفراتالحيوية.يدعمنظام RecursionOS الشركةفي تحقيق أهدافها،وهو عبارة عنمنصة تم إنشاؤهاباستخدام مجموعةمتنوعة من التقنياتالتي تعمل باستمرارعلى توسيع نطاقواحدة من أكبرمجموعات البياناتالحيوية والكيميائيةالمسجلة الملكيةفي العالم.تستخدمRecursionخوارزمياتالتعلم الآليالمعقدة لاستخلاصمجموعة من تريليوناتالعلاقات القابلةللبحث في مجاليالأحياء والكيمياءالتي لا تتقيدبالتحيز البشريمن مجموعة بياناتها.تجمعRecursionمجالاتالتكنولوجياوالأحياء والكيمياءبهدف النهوضبمستقبل الطب،وذلك بفضل التحكمفي نطاق تجريبيضخم — يصل إلىالملايين منالتجارب المعمليةأسبوعيًا —ومقياس حوسبيهائل — بامتلاكأحد أقوى أجهزةالحاسوب الفائقةفي العالم وتشغيله.

يقعالمقر الرئيسيلشركة Recursionفيسالت ليك سيتي،وهي هناك عضومؤسس في BioHive،وهي جمعية تعملفي مجال علومالحياة في ولايةيوتا.بالإضافةإلى ذلك، تمتلكRecursionمكاتبفي تورنتو ومونتريالومنطقة خليجسان فرانسيسكو.تعرفعلى المزيد عبرالموقعالإلكتروني www.Recursion.com،أو تواصلعلى Twitter و LinkedIn.

نبذةعن Cyclica
Cyclica
شركةناشئة في مجالالتكنولوجياالحيوية تسعىسعيًا جادًاإلى إنشاء محفظةأعمال رائدةوقوية ومستدامةلاكتشاف الأدويةتركز على الجهازالعصبي المركزيوعلم الأوراموأمراض المناعةالذاتية
.أنشأتCyclicaالمنصةالوحيدة القابلةللتعميم عبرالبروتيومبكامله، ما وسّعالنطاق المستهدفللأهداف ضئيلةالبيانات، بمافي ذلك بنياتAlphaFold2،ومثبطات مضخةالبروتون (PPI)،والأهداف الخاصةبالأورام المتحولة.جمعتCyclicaفريقًامتنوعًا وماهرًامن علماء الأحياءوالكيميائيينوأخصائيي الحاسوبوالمتخصصينفي مجال الأعمالالذين لديهمجميعًا شغفبتغيير نموذجاكتشاف الأدوية.وتهدفCyclicaإلىإحداث تأثيرغير مسبوق علىصحة المريضباستكشاف الأشياءالمجهولة وعلاجما يتعذر علاجه.لمزيدمن المعلومات،يرجى زيارةالموقع الإلكتروني:www.cyclicarx.com.

نبذةعن ValenceDiscovery
تستفيدValenceمنالتطور الثوريفي مجال الحوسبةفي سبيل تحسينالرعاية الصحية.وهيشركة رائدة فيتطوير تقنياتالذكاء الاصطناعيوالتقنياتالقائمة علىالفيزياء واستخدامهالتتمكن من تصميمجزيئات صغيرةمتمايزة بخصائصووظائف محسّنة.وبفضلالشراكات الناجحةالتي عقدتهاالشركة مع شركاترائدة في مجالالتكنولوجياالحيوية والأدوية،فضلًا عن سجلهاالحافل من الابتكاراتالتي لا مثيللها في المجلاتوالمؤتمراتالكبرى للذكاءالاصطناعي،جمعت Valenceفريقًامن المحترفينمتعددي التخصصاتفي القطاع والخبراءالحاسوبيينالذين ينصبتركيزهم علىتسريع التقدمفي مجموعة منبرامج اكتشافالأدوية الداخلية.تحظىشركة Valenceبدعممستثمرين بارزينفي مجال التكنولوجياالحيوية والتكنولوجياالعميقة منذالإعلان عنإطلاقها في2021،ويقع مقرهاالرئيسي فيمونتريال.لمعرفةالمزيد، يرجىزيارة الموقعالإلكتروني www.valencediscovery.com.

مسؤولالتواصل الإعلامي

Media@Recursion.com

جهةالاتصالللمستثمرين
Investor@Recursion.com

البياناتالتطلعية


تحتويهذه الوثيقةعلى معلوماتتتضمن أو تستندإلى
"بياناتتطلعية"بالمعنىالمقصود فيقانون إصلاحالتقاضي للأوراقالمالية لعام1995،ويشمل على سبيلالمثال لا الحصر،البيانات المتعلقةبتوقيت عمليتيالاستحواذ علىCyclicaوValenceواستكمالهماوالنتائج والفوائدالمرجوة منهما؛ونظام RecursionOS وغيرهمن التقنيات؛والأعمال والخططالمالية والأداء،بما في ذلك المدرجالنقدي؛ وجميعالبيانات الأخرىالتي لا تمثلحقائق تاريخية.قدتتضمن البياناتالتطلعية أولا تتضمن كلماتيمكن التعرفهذه البياناتمن خلالها مثل"تخطط"و"سوف"و"تتوقع"و"تقدر"و"تنوي"و"ترى"و"محتملة"و"ممكنة"و"تستمر"وغيرهامن العباراتالمماثلة.تخضعهذه البياناتلمخاطر وشكوكمعروفة أو مجهولةقد تؤدي إلىاختلاف النتائجالفعلية اختلافًاكبيرًا عمّاهو معبّر عنهأو متضمّن فيهذه البيانات،بما في ذلك علىسبيل المثاللا الحصر:التحدياتالمتأصلة فيالبحث والتطويرفي مجال الأدوية،بما يشمل توقيتالبرامج قبلالسريرية والسريريةونتائجها، والتيتزيد فيها احتماليةالفشل وإمكانيةأن يحدث الفشلفي أي مرحلة قبلالحصول علىالموافقة التنظيميةأو بعدها بسببالافتقار إلىالفاعلية الكافيةأو اعتباراتالسلامة أوغيرها من العوامل؛وقدرتنا علىالاستفادة منمنصة اكتشافالأدوية لديناوتحسينها؛وقدرتنا علىالحصول علىتمويل لأنشطةالتطوير وغيرهامن الأهدافالمؤسسية؛ ونجاحأنشطة التعاونلدينا؛ وقدرتناعلى الحصول علىموافقة الجهاتالتنظيمية علىالأدوية المرشحةوتسويقها فينهاية المطاف؛وقدرتنا علىالحصول على أوجهحماية الملكيةالفكرية والحفاظعليها وإنفاذها؛والهجمات الإلكترونيةأو غيرها منالاضطراباتالأخرى في أنظمتناالتكنولوجية؛وقدرتنا علىاستقطاب الموظفينالرئيسيينوتحفيزهم واستبقاءهموإدارة توسعنا؛والتضخم وغيرهمن المسائلالمرتبطة بالاقتصادالكلي؛ إلى غيرذلك من المخاطروالشكوك مثلتلك الموضحةتحت عنوان "عواملالمخاطر"فيملفاتنا المودعةلدى لجنة الأوراقالمالية والبورصاتالأمريكية،بما في ذلك تقريرناالسنوي بشأنالنموذج 10–K.وتستندجميع البياناتالتطلعية إلىالتقديراتوالتنبؤاتوالافتراضاتالحالية للإدارة،ولا تتعهد Recursionبتصحيحأو تحديث أي منهذه البيانات،سواء كان ذلكنتيجة لمعلوماتجديدة أو تطوراتمستقبلية أوغير ذلك، إلابالقدر الذييقتضيه القانونالمعمول به.

GLOBENEWSWIRE (Distribution ID )

Plastic Bank’s communities stop four billion bottles equivalent plastic from reaching the ocean

VANCOUVER, British Columbia, May 08, 2023 (GLOBE NEWSWIRE) — Plastic Bank has empowered communities around the globe to stop 80 million kilograms of plastic, the equivalent of 4 billion bottles, from reaching the ocean. This milestone is achieved in the year when the social enterprise celebrates its 10th anniversary.

As Plastic Bank enters its second decade, its mission to turn off the tap to ocean plastic evolves into a Social Recycling movement that enables people to become the change they seek in our world.

"Plastic pollution cannot be solved by impact contributions and the use of recycled materials alone. This quest has to be human–powered where we strive for perpetual behavioural change and become mindful of our impact on our planet," said David Katz, Founder & Chairman, Plastic Bank. "Our 10th anniversary is the beginning of a new era where we become the Humans of Social Recycling "" humans who believe that the creation of a wasteless world starts with us."

Shaun Frankson, Co–Founder & Chief Technology Officer, Plastic Bank, added: "Everyone has a role to play in creating an authentic and sustainable impact. It's up to each of us to take responsibility for our actions and help create a future where ocean plastic and poverty do not exist, to begin with."

"We would like to thank our communities, partners, collection members, branch owners, processors, and employees for being part of the Social Recycling movement. But this is just the beginning. Together, we will continue to reveal value, improve lives, create circular and sustainable opportunities for people and the planet," said Benjamin Lavoie, CEO, Plastic Bank.

Today, Plastic Bank and its communities have mobilized over 500 recycling communities in Southeast Asia, Latin America, and Africa, and helped more than 30,000 members to pave a path out of poverty with the support of over 170 partners, including SC Johnson, Henkel, Advansa, CooperVision, and Davines.

Join Plastic Bank's Social Recycling movement at plasticbank.com.

About Plastic Bank

Plastic Bank envisions a wasteless world. We empower the Social Recycling movement that stops ocean plastic and helps alleviate poverty. Our collection communities exchange plastic waste as currency for income and life–improving benefits. Exchanges are recorded through our proprietary blockchain–secured platform that enables traceable collection, secures income, and verifies reporting. Collected material is processed into Social Plastic feedstock for reuse in products and packaging.

PlasticBank and Social Plastic are trademarks of The Plastic Bank Recycling Corporation.

Learn more at plasticbank.com.

Additional Resources for Editor

10th Anniversary Interview with David Katz, Founder and Chairman of Plastic Bank: https://www.youtube.com/watch?v=r5CSNPOQSgI
10th Anniversary Video on the Humans of Social Recycling: https://youtu.be/nyKtE89uD–w

Contact

Esh Engao
E: estee@plasticbank.com
Ph: +1 604 263 7443 ext. 704

Melissa Cape
E: melissa@plasticbank.com
Ph: +1 604 561 4977

A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/98e64801–548c–4446–9bae–7f61ba1ea969


GLOBENEWSWIRE (Distribution ID 8833716)

Livestock Producers Seek to Integrate Biogas and Animal Protein Market in Brazil

The Toledo Bioenergy Center, in southern Brazil, is under construction, but its biodigesters are already operating with manure and the carcasses of disease-free dead animals from 16 pig farms. The goal is to generate one megawatt of power and for pig farmers to participate in the production of biogas without having to invest in their own plants, so their waste is biodigested and turned into fertilizer, instead of polluting rivers and the soil. CREDIT: Mario Osava/IPS

The Toledo Bioenergy Center, in southern Brazil, is under construction, but its biodigesters are already operating with manure and the carcasses of disease-free dead animals from 16 pig farms. The goal is to generate one megawatt of power and for pig farmers to participate in the production of biogas without having to invest in their own plants, so their waste is biodigested and turned into fertilizer, instead of polluting rivers and the soil. CREDIT: Mario Osava/IPS

By Mario Osava
TOLEDO, Brazil , May 8 2023 – It is the “best energy,” according to its producers, but biogas from livestock waste still lacks an organized market that would allow it to take off and realize its potential in Brazil, the world’s largest meat exporter.

“There is a lack of steady consumers,” said Cícero Bley Junior, who has been a pioneer in the promotion of biogas in the west of the southern state of Paraná, since he served as superintendent of Renewable Energies at Itaipu Binacional (2004-2016).

Itaipu, a gigantic hydroelectric plant shared by Brazil and Paraguay on the Paraná River which forms part of the border between the two countries, encourages nearby pig farmers to take advantage of manure to produce biogas, avoiding its disposal in the rivers that flow into the reservoir, whose contamination affects electricity generation in the long run.“The animal protein chain must also see itself as a generator of energy, just as the sugarcane sector defines itself as a sugar and energy industry since it began producing ethanol (a biogas) almost 50 years ago.” — Cícero Bley

The companies that form part of the animal protein chain, in general the meat industry that purchases animals ready for slaughter and offers breeding sows and technical assistance to livestock producers, should also buy biogas and its biomethane derivative from the breeders, Bley said.

“The animal protein chain must also see itself as a generator of energy, just as the sugarcane sector defines itself as a sugar and energy industry since it began producing ethanol (a biogas) almost 50 years ago,” he told IPS.

But the companies do not do so: none of them are affiliated with the Brazilian Biogas Association (Abiogás), he lamented. The dairy industry could greatly reduce the cost of picking up milk from farms if it replaced diesel with biomethane in its trucks, he said, to illustrate.

If no such decision is taken, there will be no large investments in gas-fired engines either, which can use natural gas or biomethane, also called renewable natural gas.

In addition to the environmental benefits, such as the reduction in water pollution and the decarbonization of energy, biogas offers economic advantages by making use of manure that was previously considered waste and converting it into biofertilizer.

It also drives a new equipment industry and local development by decentralizing energy and fertilizer production.

“It’s the best energy, for sure,” said Anelio Thomazzoni, a pig farmer from Vargeão, a small municipality of 3,500 inhabitants in the west of the state of Santa Catarina in southern Brazil. His farm has a 600-kilowatt biogas power plant and a 1-megawatt solar power plant.

“The correct use of crop waste, as fertilizer after biodigestion, made it possible for me to reduce by 100 percent the purchase of potassium chloride and phosphorus,” formerly essential fertilizers, he told IPS by phone from his town.

 

A visitor in Toledo examines the external controls of the mixer, an essential piece of equipment in the production of biogas and whose absence or mishandling can affect the operation. The complexity of biodigestion, compared to photovoltaic solar energy, is a factor that is slowing down the expected progress of biogas in Brazil, despite its multiple benefits in energy, environmental and economic terms. CREDIT: Mario Osava/IPS

A visitor in Toledo examines the external controls of the mixer, an essential piece of equipment in the production of biogas and whose absence or mishandling can affect the operation. The complexity of biodigestion, compared to photovoltaic solar energy, is a factor that is slowing down the expected progress of biogas in Brazil, despite its multiple benefits in energy, environmental and economic terms. CREDIT: Mario Osava/IPS

 

Frustrated potential

Brazil today produces only 0.5 percent of the biogas that could result from agricultural, livestock and industrial waste, urban garbage and sewage, estimated Bley, who founded the International Center for Renewable Energies-Biogás (CIBiogás) in 2013.

Brazil would have the potential to replace 70 percent of the diesel it consumes if it allocated all the biogas to the production of biomethane, according to Abiogás. In terms of electricity, it could reach almost 40 percent, but today it is limited to 353 megawatts – around 0.0018 percent of the total – according to the government’s National Electric Power Agency.

In global terms, Brazil is only ninth in biogas electricity generation, accounting for 2.1 percent of the global total, according to the International Renewable Energy Agency (IRENA).

The sugarcane sector joined the effort five years ago in promoting biogas, with larger plants for power generation or biomethane refining in the southern state of São Paulo. New initiatives are attempting to accelerate the development of this energy market in the southern region of Brazil, which concentrates two-thirds of the national production of pork.

Residues from the production of sugar and ethanol from cane represent 48 percent of Brazil’s biogas potential, followed by the animal protein chain, which accounts for 32.2 percent, estimates Abiogás. The rest comes from agricultural waste and sewage.

This large pre-treatment tank uses pig carcasses, an abundant material that is still little employed in the production of biogas, which the Toledo Bioenergy Plant in southern Brazil will process to reach a generation capacity of one megawatt, playing a sanitary role at the same time. CREDIT: Mario Osava/IPS

This large pre-treatment tank uses pig carcasses, an abundant material that is still little employed in the production of biogas, which the Toledo Bioenergy Plant in southern Brazil will process to reach a generation capacity of one megawatt, playing a sanitary role at the same time. CREDIT: Mario Osava/IPS

 

Innovative initiatives

The Bioenergy Plant under construction by CIBiogás, a nonprofit technology and innovation institution in Toledo, a city of 156,000 people in western Paraná, seeks to “validate a possible business model,” explained Juliana Somer, a construction engineer who is operations manager at the Center.

Pig farmers provide the “substrate” and receive back a part of the “digestate”, as the manure converted into a better fertilizer is called, without the gases that make up the biogas, extracted in the biodigestion process. With that they fertilize their land.

To generate electricity, biogas must have at least 55 percent methane. Carbon dioxide (CO2) is another component, making up about 40 percent. Hydrogen sulfide must be removed to prevent corrosion of the equipment.

“The objectives are environmental, social, energy-related and the dissemination of technologies,” said Rafael Niclevicz, environmental engineer at CIBiogás. To that end, an area of ​​high pig farm density was chosen, with about 120,000 hogs in five square kilometers.

The manure is collected daily, 70 percent by trucks and the pig farmers themselves, and the rest by pipelines from the nearest farms. Currently, 16 pig farmers, whose herds total about 40,000 animals, supply the plant, which also collects carcasses of disease-free dead pigs.

“The model makes sense for pig farmers who do not want to invest in facilities to produce biogas on their own. It solves the problem of waste disposal and there are socio-environmental benefits for everyone,” said Somer.

 

This Enerdimbo truck is powered by biomethane and is used to collect manure from 40 pig producers that feeds the company’s large biodigesters in southern Brazil. Solar power is added to biogas to provide 2.5 megawatts of energy, enough to supply 5,000 medium-sized households. CREDIT: Mario Osava/IPS

This Enerdimbo truck is powered by biomethane and is used to collect manure from 40 pig producers that feeds the company’s large biodigesters in southern Brazil. Solar power is added to biogas to provide 2.5 megawatts of energy, enough to supply 5,000 medium-sized households. CREDIT: Mario Osava/IPS

 

The plant is a joint project between the municipal government, which ceded the land, and Itaipu Binacional, which provided funding. The goal is an installed capacity of one megawatt.

In Ouro Verde, 22 kilometers from Toledo, a similar plant, Enerdinbo, receives the “substrate” from 40 farms within a radius of 15 kilometers, where more than 100,000 pigs are raised, for a total generation capacity of two megawatts, to which are added 500 kilowatts from a solar plant.

It is enough to provide electricity to 5,000 households, estimates EDB Energía do Brasil, the company that offers businesses and residential consumers the possibility of reducing their electricity bills by 10 percent by joining the cooperative that benefits from the electricity generated by Enerdinbo.

The business of EDB, created by businesspeople in Cascavel, 60 kilometers from Ouro Verde, is to implement small renewable energy plants to distribute the benefits of distributed generation among members of the cooperative, with the investment by the consumers themselves to save on energy costs.

Enerdinbo and the Toledo Bioenergy Plant seek to expand biogas by avoiding the difficulty for pig farmers and other small farmers or ranchers to invest in the energy business.

 

A view of one of the three large biodigesters of Enerdimbo, a plant of the EDB Energía do Brasil company that distributes the benefits of distributed electricity generation to numerous members of the cooperative, whose power bills are thus reduced by 10 percent. CREDIT: Mario Osava/IPS

A view of one of the three large biodigesters of Enerdimbo, a plant of the EDB Energía do Brasil company that distributes the benefits of distributed electricity generation to numerous members of the cooperative, whose power bills are thus reduced by 10 percent. CREDIT: Mario Osava/IPS

 

Demand from animal protein producers

“Small and medium-sized rural producers are true heroes who face various risks when deciding, in isolation, to implement a waste treatment project generated in the animal protein chain for the production of biogas on their properties,” said a manifesto from the producers and bioenergy specialists.

The document, released at the South Brazilian Biogas and Biomethane Forum on Apr. 18 in Foz do Iguaçu, in the far west of Paraná, calls for greater support from the public sector and from companies that link biogas production and the meat industry, for their “strategic value for Brazil’s energy transition.”

Only 333 animal waste biogas plants are suppliers to the national electricity grid, that is, 0.005 percent of Brazil’s 6.5 million livestock farms, the document stressed.

Can a Pledge to End TB Stick This Time Around?

In India, a doctor checks a patient’s x-ray for lung damage, which may indicate tuberculosis. Credit: ILO/Vijay Kuty

 
On May 8, there will be an interactive multistakeholder hearing at the UN as part of the preparatory process toward High-level meeting on the fight against tuberculosis. The event will be broadcast live on UN Web TV.

 
Meanwhile, the head of the World Health Organization (WHO), Tedros Adhanom Ghebreyesus, has unveiled plans to speed up the licensing and use of effective novel vaccines against tuberculosis (TB), the second leading infectious killer after COVID-19 and the 13th leading cause of death worldwide. January 2023

By Morounfolu Olugbosi
PRETORIA, South Africa, May 8 2023 – This week, the United Nations will host two days (May 8-9) of preliminary talks to plan a larger conference on tuberculosis (TB) in September. These preliminary talks will be held in New York City, the epicenter of the last significant surge of TB cases in the United States (U.S.) thirty years ago.

TB is a disease that strikes hardest in impoverished places, and the last U.S. outbreak was no different. Disadvantaged urban communities hit hard by the HIV/AIDS pandemic bore the brunt of the outbreak.

Yet, at the outbreak’s peak in 1992, less than 27,000 people in the U.S. were infected with TB. Today, an estimated 304,000 people are infected with TB in South Africa every year, while just under 3,000,000 people are infected with TB in India. The scope of the disease today far exceeds what the U.S. saw three decades ago, much less what it sees now.

TB deaths have risen across the world for two consecutive years; at this point it kills more people than COVID-19. Globally, an estimated 10.6 million people were infected with TB, but only 6.4 million people were diagnosed. The other 4.2 million people infected with this potentially lethal and debilitating disease slipped through the cracks.

In 2018, the UN held the first high-level meeting on TB. More than half of the UN member states sent delegations and 15 heads of state spoke at the event.

In a resolution endorsed by the entire UN General Assembly, every nation pledged to invest, by 2022, a total of US$2 billion annually for TB research and US$13 billion annually for TB diagnostics, treatment and care. Other commitments—to treat more people and prevent more active disease—were also made.

The world got off to a slow start on meeting these pledges and then the pandemic hit. Many of the goals were not reached. We were delighted, for example, that the annual research budget for TB research finally reached US$1 billion in 2021, because it was a critically important achievement—but the actual goal was twice that amount.

And less than half of what was pledged annually on diagnostics, treatment and prevention—US$5.4 billion—was actually provided in 2021.

There are bright spots in the fight against TB, of course. Sub-Saharan Africa is the only region that did not suffer a significant slump in TB detection during the COVID-19 pandemic. But with just under 40% of active TB infections unidentified, it still lags behind much of the world in diagnosing active cases.

Another recent highlight is the approval of new drug-resistant TB treatments that can reduce treatment time from as much as a year and a half (or sometimes even longer) to six months—including one developed by my organization, TB Alliance. African nations like Nigeria and South Africa are taking steps to rolling out this new regimen so that the spread of drug resistant infections can be curbed.

The goal pledged at the 2018 UN meeting was that, between 2018 and 2022, 1.5 million people with drug-resistant TB (DR-TB) would be treated—this is a critical slice of the TB caseload. Yet only 649,000 DR-TB patients were treated between 2018 and 2021.

There is optimism that the number of DR-TB patients who can be treated will escalate, given the new treatments, but funding and resources must increase.

The bottom line is this: TB was the most lethal infectious disease before the COVID-19 pandemic, and as COVID recedes, it is once again the worst. As leaders prepare to meet in New York City and start drafting a new set of promises in the form of the next Political Declaration on TB, we need the world to commit to ending this disease, which has killed too many people for far too long.

But this time around, we also need the world to follow through on its commitments.

Morounfolu (Folu) Olugbosi, M.D. is the Senior Director, Clinical Development at TB Alliance. He works with the clinical development of products in the TB Alliance portfolio and helps to oversee clinical trials in TB endemic countries and heads the South Africa office.

IPS UN Bureau

 


!function(d,s,id){var js,fjs=d.getElementsByTagName(s)[0],p=/^http:/.test(d.location)?’http’:’https’;if(!d.getElementById(id)){js=d.createElement(s);js.id=id;js.src=p+’://platform.twitter.com/widgets.js’;fjs.parentNode.insertBefore(js,fjs);}}(document, ‘script’, ‘twitter-wjs’);  

ECW High-Level Interview with New ECW Global Champion, Folly Bah Thibault

By External Source
May 8 2023 (IPS-Partners)

 

Folly Bah Thibault was appointed as Education Cannot Wait’s Global Champion on 25 April 2023. Through her work for Al Jazeera, France24, Radio France International and Voice of America, Thibault has become one of the most recognized and respected journalists in the world. Her coverage of some of the world’s most pressing events as a journalist for Al Jazeera is shedding light on forgotten crises across the globe.

Born in Conakry, Guinea, Thibault received her bachelor’s and master’s degrees from Howard University and American University in the United States. After graduating, Thibault hosted a show for Voice of America that sought to reunite families separated by conflict in Sierra Leone and Liberia. It wasn’t long before her passion for telling stories and reporting took her to Paris and Radio France Internationale, where she presented the morning show on the English Channel. She later joined France24 television as an Anchor, before joining Al Jazeera English as a Principal Presenter in 2010 and relocating to Qatar. When she’s not at Al Jazeera’s headquarters in Doha, Thibault is a sought-after moderator and public speaker. In 2019, she launched her foundation – Elle Ira à l’Ecole – which helps young girls in Guinea get an education.

ECW: Congratulations on your recent appointment as an ECW Global Champion! What do you hope to accomplish as we work together to push education in emergencies and protracted crises to the top of the international agenda?

Folly Bah Thibault: First, let me start by saying, I’m honoured to be joining Education Cannot Wait as a Global Champion. Through this role – and our collective efforts with ECW’s wide group of donors and strategic partners – I’m hoping to continue advocating for increased funding for education in emergencies and protracted crises, to leverage my networks to connect people, resources, know-how and talents, and to ensure our collective storytelling on education does not forget the 222 million crisis-impacted children and adolescents that so urgently need our support.

Education is a game changer. It lifts up lives, transforms economies and societies, and provides renewed hope for an entire generation of girls and boys whose futures have been disrupted by conflict, climate change, displacement and other crises. Taken together with other actions, education is our single best investment in building peace in our times.

I’m thrilled to be working with Education Cannot Wait. As I spoke with its donors and partners at February’s High-Level Financing Conference in Geneva, it became clear to me, ECW is a model for UN Reform and a New Way of Working.

As the UN’s global fund for education in emergencies, Education Cannot Wait is delivering across the globe with humanitarian speed and development depth. This means girls and boys in places like Afghanistan, Bangladesh, Lebanon, South Sudan and beyond have a chance to go to school. And ensuring they can do it safely – to learn, to dream, to find new opportunities, and break cycles of poverty, displacement, hunger and conflict forever. ECW represents the UN at its best and I’m honoured and thrilled to be a part of this movement.

ECW: Following the example of ECW’s new donor, Qatar, which recently announced US$20 million in new funding to ECW, why should new government and private sector donors from around the world – including the Gulf States – invest in education for crisis-affected children living on the frontlines of armed conflict, forced displacement and climate-induced disasters?

Folly Bah Thibault: The new funding investment announced at ECW’s #HLFC2023 by the Qatar Development Fund in cooperation with the Education Above All Foundation provides a clear example of Qatar’s new leadership on the global stage. Qatar has stepped up, and we hope this will inspire others to do the same, as we work together to deliver on our promise of reaching 20 million children and adolescents in the next four years.

Investing in education for children affected by various crises is investing in a better future for the Middle East, the Sahel, and other regions. It’s about investing in the end to hunger and poverty worldwide, it’s investing in more resilient economies and, above all, it’s about investing in our most precious natural resource: our children.

The economic returns are impressive. For private sector donors, investing in education builds economic security, opens and expands markets, and future proofs investments to balance out risk and reward in our fast-changing global marketplace.

The social returns are equally impressive. When you teach girls to read, to write, to excel in science, technology, engineering and math, you are ensuring their equality, empowerment and hope.

For girls like Fatuma in Ethiopia, safe, holistic, quality learning environments mean access to school meals, mental health and psychosocial support, and safe and protective learning environments. For Syrian refugees like Jana and Yara, access to an education means access to new technologies, remote learning platforms and innovative learning methods that will transform the way we deliver education for the world’s crisis-impacted children and adolescents.

ECW: With COP28 on the horizon, the climate crisis is an education crisis for millions of children across the world. With climate change (drought, floods, etc.), increasingly impacting the education of children, notably in the Sahel and the Horn of Africa, why is it crucial to address climate change now, including through education?

Folly Bah Thibault: Climate change has become one of the most pressing issues of our time. It affects every single person on our planet one way or another. At this year’s Climate Talks in Dubai, leaders will address how we can adapt our economy, our society and our people in the face of a changing climate. Given the power of education to transform lives and build a better world, we must connect the dots between climate action and our work to ensure education for all.

We must also consider the power of education in delivering on the targets outlined in the Paris Agreement. Not only will this activate an entire generation of responsible citizens for our troubled planet, but it will also support our efforts to deliver on our promises of a better world as outlined in the Sustainable Development Goals.

This year’s climate talks provide us with a unique opportunity to propel education – especially for the world’s most vulnerable: crisis-affected girls and boys – to the top of the climate agenda and investments across the world.

Imagine what will happen if even more people are impacted by horrific climate-driven disasters like the drought in the Horn of Africa, floods in Pakistan or recurrent desertification and climate displacement events across the Sahel? Nearly half of the world’s children – approximately 1 billion girls and boys – are living in countries that are designated at “extremely high-risk” from the effects of climate change, and some estimates indicate that as many as 140 million more people could be displaced by climate change by 2050 across South Asia, sub-Saharan Africa and Latin America.

The world’s most marginalized and vulnerable children have the most to lose. Without the safety and protection of quality education environments, they are at a higher risk of sexual exploitation, child marriage, adolescent pregnancy, child labour, recruitment by armed groups and other human rights abuses.

So how can education for all help us to address the climate crisis? Education means a pathway to peace, a pathway to reduced risks from natural disasters, a pathway to greater incomes and greater resilience in the face of future emergencies. It is a pathway to a more sustainable future.

ECW: You’ve been named as ‘One of the Most Influential Africans Working Today’. As a journalist, thought-leader and agenda-setter, how do you think education can help transform Africa and how should ECW and humanitarian partners align investments across the humanitarian-development-peace nexus?

Folly Bah Thibault: This is a unique opportunity for us to reimagine education in Africa. The continent is young, vibrant and is on the rise. By 2050, there will be about 1 billion children under the age of 18 across Africa. A dynamic population with limitless potential – but despite progress, millions of African children are still out of school. When they are in school, the quality of education they receive often lags behind.

Imagine what the world would be like if every child in Africa – and indeed every child everywhere – were able to access 12 years of quality, inclusive education. It would enhance the economy and security, and reduce displacement and migration across the continent. In other words, it’s the key to unlocking Africa’s full potential and achieving its development goals.

ECW’s investments work in partnerships with governments, donors, civil society, the private sector, UN agencies and other key partners to deliver humanitarian and development support. We do this by bringing partners together, empowering local organizations, embracing innovation, and working tirelessly to put human rights and human dignity first in everything ECW does, its investments provide the depth and impact we need to really transform education in Africa and support long-term development across the continent.

ECW: Your foundation Elle Ira à l’Ecole helps young girls in Guinea get an education. Why is girls’ education so important to you personally, and so crucial to achieving the Sustainable Development Goals?

Folly Bah Thibault: I come from a family of five girls – born into a culture and a society which for a long time didn’t believe in the value of having girls and did not see women as equal members of society. In my Fulani culture, there’s long been a preference for boys. It is a very patriarchal society which sees boys as future providers while girls are often considered a burden on their family. Well, my mother’s lifelong goal – after having had five daughters – has been to change that perception. She invested all her energy in our education, to prove to society, and even to her own family, that girls, if they are educated, if they’re given the opportunity to learn, can be as successful and accomplish even more than boys. So that’s why girls’ education is important to me personally. I’ve seen what having a good education has done for my sisters and me, it’s empowered us, allowed us to become independent, to make our decisions. And that is what I want to achieve through my foundation, ‘Elle ira a l’ecole’. I want to help little girls in Africa and beyond to have a quality education, so they can have courage and independence to make decisions that affect their lives. Informed decisions on important issues like their health, their reproductive rights and careers.

Girls’ education is not only important for women’s empowerment but it’s also essential to the economic and structural development of any society. It helps break intergenerational cycles of poverty and disadvantage. Education permeates all sectors of society and affects all socio-economic and political decisions of any country. The education of girls today is the best strategy to achieve the Sustainable Development Goals because it reduces poverty in all its forms. It helps end hunger by achieving food security…Educated mothers ensure the education for their own children, thus breaking a vicious cycle of generational poverty. And as I’ve witnessed through the work of our foundation, school is not only a place of learning for many of our girls, it’s also a place of refuge, a safe haven. It provides protection against child marriage. In my home country of Guinea, the majority of girls are married before the age of 18, more than 20 percent before the age of 15. By enrolling and keeping the girls in school, we’re also ensuring that they’re not married off while they’re still underage. The longer a girl stays in school, the less likely she is to be married before the age of 18 and have children during her teenage years. So, educating girls is a crucial springboard for sustainable development in all its forms.

ECW: Our readers would like to know a little about you on a personal level and we know that ‘readers are leaders.’ What are some of the books that have most influenced you, personally and professionally, and why would you recommend them to others?

Folly Bah Thibault: Jacques Ellul’s ‘Propaganda – The Formation of Men’s Attitudes’ which I studied while in college, had a lot of influence on my career as a journalist. It changed the way I looked at the news media and politicians. Ellul argues that propaganda, whether its ends are good or bad is not only a threat to democracy, but the biggest threat to humanity. And authors like Chinua Achebe and Chimamanda Ngozie Adichie have influenced me a great deal. They’re both masterful storytellers who balance the personal, the political, intimate and historical to paint a distinct picture of the African experience. Chinua Achebe’s ‘Things Fall Apart’ is no doubt the greatest work of literature to come out of Africa. It has had a profound impact on me. I had grown up studying French literature, Victor Hugo and Camus, but Achebe’s extraordinary work was a revelation for me. It is the most powerful depictions of colonization and its impact, told in an authentic African voice. It is a timeless reminder for me as a journalist that some stories are best told by the people who live them.

 


!function(d,s,id){var js,fjs=d.getElementsByTagName(s)[0],p=/^http:/.test(d.location)?’http’:’https’;if(!d.getElementById(id)){js=d.createElement(s);js.id=id;js.src=p+’://platform.twitter.com/widgets.js’;fjs.parentNode.insertBefore(js,fjs);}}(document, ‘script’, ‘twitter-wjs’);  

The Privilege of Making a Choice

By Yasmine Sherif
NEW YORK, May 8 2023 – A civilian student named Saber was caught in the crossfire in Khartoum. He had two choices: either flee and lose everything; or die. But within a moment his option to choose was violently denied: he died.

As a result of the brutal internal armed conflict in Sudan right now, UNHCR projects that 860,000 people will flee across the borders as refugees and returnees into the Central African Republic, Chad, Egypt, Ethiopia, Eritrea and South Sudan. About 50% will be children and adolescents below 18.

Will they arrive alive? They can’t choose. They can only hope.

Making it worse, none of the neighboring countries has the financial and structural capacity to manage such influx, and yet they too, have no choice.

Indeed, an enormous international response will be required to support the Refugee Response Plan developed by 134 partners, including UN agencies, national and international NGOs and civil society groups, and launched on 4 May 2023.

Fleeing children and adolescents will need immediate psycho-social support and mental health care to cope with the stress and trauma of the conflict and perilous escape. They will need school meals. They will need water and sanitation. They will need protection. In the deep despair of their young lives, they will need a sense of normalcy and hope for their future. They need it now and a rapid response to establishing education can meet these needs.

Or to paraphrase ECW’s new Global Champion, the world-renowned journalist, Folly Bah Thibault – who reaffirms the need for speed and quality: the humanitarian-development nexus in action – in her high-level interview in this month’s ECW Newsletter, “We need to deliver with humanitarian speed and development depth.”

The choice is ours.

ECW is now traveling to the region to support host-governments, UN and civil society colleagues who jointly produced the Refugee Response Plan and who are on the ground working day and night in difficult circumstances. ECW will provide support both through an initial First Emergency Response investment and through our global advocacy.

We all have a choice to act now. Our choice is not between losing everything or die. Our choice is between action or inaction. Between humanity and indifference.

Prior to the breakout of the internal armed conflict in Sudan, Samiya*, a 17-year-old refugee student, wrote in her recent Postcard From the Edge: “Education is our future dream. Education is one of the most important factors to progress in life. Through education, people can thrive in their lives; they can also develop their skills and improve their life quality.”

We can help make Samya’s dream come true at the hardest, darkest moment of her life. Samiya does not have that choice. Only, we have that choice. Let us recognize it for what it is: as a privilege or blessing of choosing responsibility and humanity.

Yasmine Sherif is Director of Education Cannot Wait.

IPS UN Bureau

 


!function(d,s,id){var js,fjs=d.getElementsByTagName(s)[0],p=/^http:/.test(d.location)?’http’:’https’;if(!d.getElementById(id)){js=d.createElement(s);js.id=id;js.src=p+’://platform.twitter.com/widgets.js’;fjs.parentNode.insertBefore(js,fjs);}}(document, ‘script’, ‘twitter-wjs’);  

Statement on the G7 Hiroshima Summit, the Ukraine Crisis and “No First Use” of Nuclear Weapons

Dr. Daisaku Ikeda. Credit: Seikyo Shimbun

By Daisaku Ikeda
TOKYO, Japan, May 8 2023 – The Ukraine crisis, which in addition to bringing devastation to the people of that country has had severe impacts on a global scale—even giving rise to the specter of nuclear weapons use—has entered its second year. Against this backdrop and amid urgent calls for its resolution, the G7 Summit of leading industrial nations will be held in Hiroshima, Japan, from May 19 to 21.

In February of this year, an emergency special session of the UN General Assembly was held, where a resolution calling for the early realization of peace in Ukraine was adopted. Among the operative paragraphs of the resolution was one that urged the “immediate cessation of the attacks on the critical infrastructure of Ukraine and any deliberate attacks on civilian objects, including those that are residences, schools and hospitals.”

With that as a first essential step, all concerned parties must come together to create a space for deliberations toward a complete cessation of hostilities. Here I would like to propose that, as negotiations advance through the cooperative efforts of the concerned countries, they be joined by representatives of civil society, such as the physicians and educators who work in schools and hospitals to protect and nurture people’s lives and futures, participating as observers.

In March, the leaders of Russia and China issued a joint statement following their summit meeting which reads in part: “The two sides call for stopping all moves that lead to tensions and the protraction of fighting to prevent the crisis from getting worse or even out of control.” This is aligned with the resolution adopted by the emergency special session of the UN General Assembly.

The G7 Hiroshima Summit should develop concrete plans for negotiations that will lead to a cessation of hostilities.

I also urge the G7 to commit at the Hiroshima Summit to taking the lead in discussions on pledges of No First Use of nuclear weapons. The current crisis is without parallel in the length of time that the threat of use and the fear of actual use of nuclear weapons have persisted without cease.

Since the bombings of Hiroshima and Nagasaki, the hibakusha of those cities, in coordination with the larger civil society movement, have stressed the inhumane nature of nuclear weapons; non-nuclear-weapon states have engaged in continuous diplomatic efforts; and the states possessing nuclear weapons have exercised self-restraint. As a result, the world has somehow managed to maintain a seventy-seven-year record of non-use of nuclear weapons.

If international public opinion and the taboo against the use of nuclear weapons were to fail to provide their braking function, nuclear deterrence policy will compel humankind to stand on a precipitous ledge, never knowing when it might give way.

Since the start of the Ukraine crisis, I have written two public statements. In both, I referenced the joint statement by the five nuclear-weapon states (United States, Russia, United Kingdom, France and China) made in January 2022, which reiterated the principle that “a nuclear war cannot be won and must never be fought,” and called for it to serve as the basis for reducing the risk of nuclear weapons use.

Also of important note is the declaration issued by the G20 group in Indonesia last November, which stated: “The use or threat of use of nuclear weapons is inadmissible.”

The G20 member countries include nuclear-weapon states as well as nuclear-dependent states. It is deeply significant that these countries have officially expressed their shared recognition that the use or threat of use of nuclear weapons is “inadmissible”—the animating spirit of the Treaty on the Prohibition of Nuclear Weapons (TPNW).

It is vital that this message be communicated powerfully to the world from Hiroshima.

As the G7 leaders revisit the actual consequences of a nuclear weapon detonation and the bitter lessons of the nuclear era, I urge that they initiate earnest deliberations on making pledges of No First Use so that their shared recognition of the inadmissible nature of nuclear weapons can find expression in changed policies.

If agreement could be reached on the principle of No First Use, which was at one point included in drafts of the final statement for last year’s NPT Review Conference, this would establish the basis on which states could together transform the challenging security environments in which they find themselves. I believe it is vital to make the shift to a “common security” paradigm.

Commitment to policies of No First Use is indeed a “prescription for hope.” It can serve as the axle connecting the twin wheels of the NPT and TPNW, speeding realization of a world free from nuclear weapons.

For our part, the SGI has continued to work with the world’s hibakusha, the International Campaign to Abolish Nuclear Weapons (ICAN)—which arose from its parent body IPPNW—and other organizations first for the adoption and now the universalization of the TPNW. As members of civil society, we are committed to promoting the prompt adoption of policies of No First Use of nuclear weapons, generating momentum to transform our age.

The author is Peace builder and Buddhist leader Daisaku Ikeda, who is President of the Soka Gakkai International (SGI). https://www.daisakuikeda.org/ Read full statement here full statement.

IPS UN Bureau

 


!function(d,s,id){var js,fjs=d.getElementsByTagName(s)[0],p=/^http:/.test(d.location)?’http’:’https’;if(!d.getElementById(id)){js=d.createElement(s);js.id=id;js.src=p+’://platform.twitter.com/widgets.js’;fjs.parentNode.insertBefore(js,fjs);}}(document, ‘script’, ‘twitter-wjs’);